An interpenetrating HA/G/CS biomimic hydrogel via Diels–Alder click chemistry for cartilage tissue engineering

Correction for ‘An injectable hyaluronic acid/PEG hydrogel for cartilage tissue engineering formed by integrating enzymatic crosslinking and Diels–Alder “click chemistry”’ by Feng Yu et al., Polym. Chem., 2014, 5, 1082–1090.

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An injectable hyaluronic acid/PEG hydrogel for cartilage tissue engineering formed by integrating enzymatic crosslinking and Diels–Alder “click chemistry”

Polymer Chemistry ◽

10.1039/c3py00869j ◽

2014 ◽

Vol 5 (3) ◽

pp. 1082-1090 ◽

Cited By ~ 93

Author(s):

Feng Yu ◽

Xiaodong Cao ◽

Yuli Li ◽

Lei Zeng ◽

Bo Yuan ◽

...

Keyword(s):

Tissue Engineering ◽

Hyaluronic Acid ◽

Click Chemistry ◽

Compressive Stress ◽

Shape Recovery ◽

Cartilage Tissue Engineering ◽

Diels Alder ◽

Cartilage Tissue ◽

Fatigue Properties

Injectable HA/PEG hydrogel was crosslinked by integrating the enzymatic crosslinking and Diels–Alder click chemistry and showed excellent shape recovery and anti-fatigue properties at a high compressive stress.

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Injectable dextran hydrogels fabricated by metal-free click chemistry for cartilage tissue engineering

Materials Science and Engineering C ◽

10.1016/j.msec.2016.12.053 ◽

2017 ◽

Vol 73 ◽

pp. 21-30 ◽

Cited By ~ 29

Author(s):

Xiaoyu Wang ◽

Zihan Li ◽

Ting Shi ◽

Peng Zhao ◽

Kangkang An ◽

...

Keyword(s):

Tissue Engineering ◽

Click Chemistry ◽

Cartilage Tissue Engineering ◽

Cartilage Tissue ◽

Metal Free

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In situ cross-linkable hyaluronic acid hydrogels using copper free click chemistry for cartilage tissue engineering

Polymer Chemistry ◽

10.1039/c7py01654a ◽

2018 ◽

Vol 9 (1) ◽

pp. 20-27 ◽

Cited By ~ 20

Author(s):

Sang-Soo Han ◽

Hong Yeol Yoon ◽

Ji Young Yhee ◽

Myeong Ok Cho ◽

Hye-Eun Shim ◽

...

Keyword(s):

Tissue Engineering ◽

Hyaluronic Acid ◽

Click Chemistry ◽

Click Reaction ◽

Cartilage Tissue Engineering ◽

Cartilage Tissue

We develop a biocompatible and in situ HA hydrogel via a bioorthogonal click reaction for cartilage tissue engineering.

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A Hyaluronic Acid Based Injectable Hydrogel Formed via Photo-Crosslinking Reaction and Thermal-Induced Diels-Alder Reaction for Cartilage Tissue Engineering

Polymers ◽

10.3390/polym10090949 ◽

2018 ◽

Vol 10 (9) ◽

pp. 949 ◽

Cited By ~ 7

Author(s):

Gang Wang ◽

Xiaodong Cao ◽

Hua Dong ◽

Lei Zeng ◽

Chenxi Yu ◽

...

Keyword(s):

Mechanical Properties ◽

Tissue Engineering ◽

Hyaluronic Acid ◽

Cell Activity ◽

Cartilage Tissue Engineering ◽

Diels Alder ◽

Cartilage Tissue ◽

Good Prospect ◽

Crosslinking Reaction ◽

Injectable Hydrogel

A hyaluronic acid (HA) based injectable hydrogel with gradually increasing mechanical properties was synthesized via photo-crosslinking reaction and thermal-induced Diels-Alder (DA) reaction. The injectable hydrogel can quickly gelate within 30 s by photo-crosslinking of HA-furan under the catalysis of lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP). This injectable property is beneficial to keep the encapsulated cell activity and convenient for clinical operation. And the mechanical properties can be control from 4.86 to 10.66 kPa by exposure time. Then, the thermal-induced DA click chemistry further occurs between furan groups and maleimide groups which gradually promoted the crosslinking density of the injectable hydrogel. The mechanical properties of the injectable hydrogel can be promoted to 21 kPa. ATDC-5 cells were successfully encapsulated in the injectable hydrogel and showed good activity. All the results suggested that the injectable hydrogel with gradually increasing mechanical properties formed by photo-crosslinking reaction and thermal-induced DA reaction has a good prospect of application in cartilage tissue engineering.

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