In situ cross-linkable hyaluronic acid hydrogels using copper free click chemistry for cartilage tissue engineering

2018 ◽  
Vol 9 (1) ◽  
pp. 20-27 ◽  
Author(s):  
Sang-Soo Han ◽  
Hong Yeol Yoon ◽  
Ji Young Yhee ◽  
Myeong Ok Cho ◽  
Hye-Eun Shim ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Hyaluronic Acid ◽  
Click Chemistry ◽  
Click Reaction ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue

We develop a biocompatible and in situ HA hydrogel via a bioorthogonal click reaction for cartilage tissue engineering.

scholarly journals Correction: An injectable hyaluronic acid/PEG hydrogel for cartilage tissue engineering formed by integrating enzymatic crosslinking and Diels–Alder “click chemistry”

2018 ◽  
Vol 9 (28) ◽  
pp. 3959-3960 ◽  
Author(s):  
Feng Yu ◽  
Xiaodong Cao ◽  
Yuli Li ◽  
Lei Zeng ◽  
Bo Yuan ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Hyaluronic Acid ◽  
Click Chemistry ◽  
Cartilage Tissue Engineering ◽  
Diels Alder ◽  
Cartilage Tissue

Correction for ‘An injectable hyaluronic acid/PEG hydrogel for cartilage tissue engineering formed by integrating enzymatic crosslinking and Diels–Alder “click chemistry”’ by Feng Yu et al., Polym. Chem., 2014, 5, 1082–1090.

scholarly journals Injectable in situ forming biodegradable chitosan–hyaluronic acid based hydrogels for cartilage tissue engineering

Biomaterials ◽  
2009 ◽  
Vol 30 (13) ◽  
pp. 2499-2506 ◽  
Author(s):  
Huaping Tan ◽  
Constance R. Chu ◽  
Karin A. Payne ◽  
Kacey G. Marra
Keyword(s):  
Tissue Engineering ◽  
Hyaluronic Acid ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue ◽  
In Situ Forming

An injectable hyaluronic acid/PEG hydrogel for cartilage tissue engineering formed by integrating enzymatic crosslinking and Diels–Alder “click chemistry”

2014 ◽  
Vol 5 (3) ◽  
pp. 1082-1090 ◽  
Author(s):  
Feng Yu ◽  
Xiaodong Cao ◽  
Yuli Li ◽  
Lei Zeng ◽  
Bo Yuan ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Hyaluronic Acid ◽  
Click Chemistry ◽  
Compressive Stress ◽  
Shape Recovery ◽  
Cartilage Tissue Engineering ◽  
Diels Alder ◽  
Cartilage Tissue ◽  
Fatigue Properties

Injectable HA/PEG hydrogel was crosslinked by integrating the enzymatic crosslinking and Diels–Alder click chemistry and showed excellent shape recovery and anti-fatigue properties at a high compressive stress.

An injectable, in situ forming type II collagen/hyaluronic acid hydrogel vehicle for chondrocyte delivery in cartilage tissue engineering

2014 ◽  
Vol 4 (2) ◽  
pp. 149-158 ◽  
Author(s):  
Leena-Stiina Kontturi ◽  
Elina Järvinen ◽  
Virpi Muhonen ◽  
Estelle C. Collin ◽  
Abhay S. Pandit ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Hyaluronic Acid ◽  
Cartilage Tissue Engineering ◽  
Type Ii Collagen ◽  
Cartilage Tissue ◽  
Type Ii ◽  
In Situ Forming ◽  
Hyaluronic Acid Hydrogel

scholarly journals Digital Light Processing Bioprinted Human Chondrocyte-Laden Poly (γ-Glutamic Acid)/Hyaluronic Acid Bio-Ink towards Cartilage Tissue Engineering

Biomedicines ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 714
Author(s):  
Alvin Kai-Xing Lee ◽  
Yen-Hong Lin ◽  
Chun-Hao Tsai ◽  
Wan-Ting Chang ◽  
Tsung-Li Lin ◽  
...  
Keyword(s):  
United States ◽  
Tissue Engineering ◽  
Hyaluronic Acid ◽  
Glutamic Acid ◽  
Cellular Proliferation ◽  
Cartilage Tissue Engineering ◽  
Cartilage Regeneration ◽  
The United States ◽  
Cartilage Injury ◽  
Cartilage Tissue

Cartilage injury is the main cause of disability in the United States, and it has been projected that cartilage injury caused by osteoarthritis will affect 30% of the entire United States population by the year 2030. In this study, we modified hyaluronic acid (HA) with γ-poly(glutamic) acid (γ-PGA), both of which are common biomaterials used in cartilage engineering, in an attempt to evaluate them for their potential in promoting cartilage regeneration. As seen from the results, γ-PGA-GMA and HA, with glycidyl methacrylate (GMA) as the photo-crosslinker, could be successfully fabricated while retaining the structural characteristics of γ-PGA and HA. In addition, the storage moduli and loss moduli of the hydrogels were consistent throughout the curing durations. However, it was noted that the modification enhanced the mechanical properties, the swelling equilibrium rate, and cellular proliferation, and significantly improved secretion of cartilage regeneration-related proteins such as glycosaminoglycan (GAG) and type II collagen (Col II). The cartilage tissue proof with Alcian blue further demonstrated that the modification of γ-PGA with HA exhibited suitability for cartilage tissue regeneration and displayed potential for future cartilage tissue engineering applications. This study built on the previous works involving HA and further showed that there are unlimited ways to modify various biomaterials in order to further bring cartilage tissue engineering to the next level.

scholarly journals New “Tribo-bioreactor” for In-situ Monitoring of the Mechanical Stress Transmission at the Cellular Level: Application to Cartilage Tissue Engineering

Biotribology ◽  
2021 ◽  
Vol 25 ◽  
pp. 100158
Author(s):  
Amira Hannoun ◽  
Emeline Perrier-Groult ◽  
Livia Cureu ◽  
Marielle Pasdeloup ◽  
Yves Berthier ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Mechanical Stress ◽  
Cartilage Tissue Engineering ◽  
Cellular Level ◽  
In Situ Monitoring ◽  
Cartilage Tissue ◽  
Stress Transmission

Injectable In Situ Self-Cross-Linking Hydrogels Based on Poly(l-glutamic acid) and Alginate for Cartilage Tissue Engineering

2014 ◽  
Vol 15 (12) ◽  
pp. 4495-4508 ◽  
Author(s):  
Shifeng Yan ◽  
Taotao Wang ◽  
Long Feng ◽  
Jie Zhu ◽  
Kunxi Zhang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Glutamic Acid ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue ◽  
Cross Linking

Enzymatically-crosslinked injectable hydrogels based on biomimetic dextran–hyaluronic acid conjugates for cartilage tissue engineering

Biomaterials ◽  
2010 ◽  
Vol 31 (11) ◽  
pp. 3103-3113 ◽  
Author(s):  
R. Jin ◽  
L.S. Moreira Teixeira ◽  
P.J. Dijkstra ◽  
C.A. van Blitterswijk ◽  
M. Karperien ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Hyaluronic Acid ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue ◽  
Injectable Hydrogels

scholarly journals A biomimetic extracellular matrix for cartilage tissue engineering centered on photocurable gelatin, hyaluronic acid and chondroitin sulfate

2014 ◽  
Vol 10 (1) ◽  
pp. 214-223 ◽  
Author(s):  
Peter A. Levett ◽  
Ferry P.W. Melchels ◽  
Karsten Schrobback ◽  
Dietmar W. Hutmacher ◽  
Jos Malda ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Hyaluronic Acid ◽  
Chondroitin Sulfate ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue
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