INTRODUCTION: Congestive Heart Failure is a complex physiological syndrome caused from structural or functional alterations to the
myocardium. Lactate is produced by anaerobic metabolism and is secreted by the Brain-Natriuretic peptide heart ventricles in response to left
ventricular stretching or wall tension.
AIM: The aim of the study was to evaluate Brain-Natriuretic Peptide, Lactate levels and Blood pressure in Congestive Heart Failure patients and
compared them with healthy individual.
MATERIALS AND METHODS: Total 80 participants who fullled the inclusion and exclusion criteria were enrolled in the study. They were
divided into two group i.e., case and control group. Case group included 40 patients of Congestive Heart Failure, age between 18-65 years and
control group comprised of 40 healthy individuals with similar age range. Blood sample were drawn and analyzed for the evaluation of Serum
lactate and Brain-Natriuretic Peptide. Blood Pressure was also measured in both the groups.
RESULT: The present study has demonstrated that the level of Brain-Natriuretic Peptide and lactate were signicantly high in Congestive heart
failure patients when compared with control group. Systolic and Diastolic blood pressure were also higher among patients group.
CONCLUSION: The results of the study suggested that the levels of Lactate and Brain-Natriuretic Peptide were high in Congestive heart failure
patients when compared with healthy individual. Systolic and Diastolic blood pressure were also higher among patients group. Elevated lactate and
Brain-Natriuretic Peptide level can be recommended as useful indicator of poor prognosis and hence can be helpful in early identication of
patients at risk.
Genetic Factors Influencing B-type Natriuretic Peptide-Mediated Production of Cyclic Guanosine Monophosphate and Blood Pressure Effects in Heart Failure Patients
