Comparative prognostic value of low-density lipoprotein cholesterol and C-reactive protein in patients with stable coronary artery disease treated with percutaneous coronary intervention and chronic statin therapy

2014 ◽  
Vol 15 (3) ◽  
pp. 131-136 ◽  
Author(s):  
Gjin Ndrepepa ◽  
Siegmund Braun ◽  
Tomohisa Tada ◽  
Elena Guerra ◽  
Heribert Schunkert ◽  
...  
Keyword(s):  
Prognostic Value ◽  
Stable Coronary Artery Disease ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Coronary Intervention ◽  
C Reactive Protein ◽  
Low Density Lipoprotein Cholesterol ◽  
Reactive Protein ◽  
Percutaneous Coronary ◽  
Artery Disease

scholarly journals The C-reactive protein to albumin ratio is a novel prognostic factor in patients with stable coronary artery disease following percutaneous coronary intervention

2020 ◽  
Author(s):  
Yang Zou ◽  
Mingchun Zhong ◽  
Hui Zeng ◽  
Xiaohua Chen ◽  
Guotai Sheng
Keyword(s):  
Poor Prognosis ◽  
Prognostic Value ◽  
Inflection Point ◽  
Stable Coronary Artery Disease ◽  
Coronary Intervention ◽  
C Reactive Protein ◽  
Albumin Ratio ◽  
Reactive Protein ◽  
Percutaneous Coronary ◽  
Artery Disease

Abstract Background Previous studies have shown that both C-reactive protein (CRP) and albumin (Alb) are the prognostic factors of cardiovascular. However, the prognostic value of C-reactive protein to albumin ratio (CAR) in patients with stable coronary artery disease (SCAD) is unclear. Methods This was a retrospective cohort study that continuously enrolled 204 patients with newly diagnosed SCAD between October 2014 and October 2017; the mean follow-up time was 793.75 ± 430.26 days. The Cox proportional hazard model was used to evaluate the prognostic value of CAR in patients with SCAD. Results In the Kaplan–Meier analysis, the long-term MACE (major adverse cardiac events) free survival rate of patients with high CAR levels decreased significantly (P = 0.015). Of the note, after adjusting for other covariates in multivariate analysis, CAR was still independently positively correlated with poor prognosis in SCAD patients (HR = 1.03, 95% CI:1.01–1.06, P = 0.02, P for trend = 0.024). Additionally, we identified a nonlinear association between CAR and poor prognosis of SCAD by the generalized additive model (GAM). Then, through the two-piecewise linear regression model, we calculated that the inflection point of CAR was 3.933 (log-likelihood ratio test P = 0.02). When CAR ≤ 3.933, there was a positive correlation between CAR and MACE in patients with SCAD (HR:1.48, 95% CI:1.10–1.99, P = 0.009). While on the right hand of the inflection point (CAR > 3.933), the positive correlation between the two tends to be saturated (HR:1.01, 95% CI:0.97–1.05, P = 0.64). Conclusions This study indicated an association between higher CAR levels and increased risk of MACE in patients with SCAD for the first time, and measurement of CAR at admission may be a valuable predictor of the prognostic outcome in patients with SCAD treated by the percutaneous coronary intervention.

C-Reactive Protein Predicts the Severity of Coronary Artery Disease Beyond Low-Density Lipoprotein Cholesterol

Angiology ◽  
2011 ◽  
Vol 63 (3) ◽  
pp. 218-222 ◽  
Author(s):  
Hai-Hang Liu ◽  
Dong Zhao ◽  
Chang-Sheng Ma ◽  
Xiao-Hui Liu ◽  
Qiang Lv ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
C Reactive Protein ◽  
Low Density Lipoprotein Cholesterol ◽  
Reactive Protein ◽  
Artery Disease

Prospective studies and clinical trials have shown that C-reactive protein (CRP) independently predicts the occurrence of cardiovascular events, even in individuals without hypercholesterolemia. We evaluated whether CRP can predict the severity of coronary artery stenosis in patients with lower low-density lipoprotein cholesterol (LDL-C) levels. A total of 418 patients with lower LDL-C (<3.37 mmol/L) who underwent coronary angiography were recruited. The median levels of CRP increased according to the number of stenotic vessels. Multivariable adjustment model indicated that CRP was associated with the severity of coronary artery disease (CAD) in the top to the bottom third comparison of CRP levels, yielding an odds ratio of 1.72 (95% confidence interval: 1.08-2.74); this trend was preserved after excluding the confounding effect of statin treatment. C-reactive protein may serve as a useful biomarker for improving the risk assessment and secondary prevention of CAD patients without hypercholesterolemia.

scholarly journals Oxidized Low Density Lipoprotein and High Sensitive C-Reactive Protein in Non-Diabetic, Pre-Diabetic and Diabetic Patients in the Acute Phase of the First Myocardial Infarction Treated by Primary Percutaneous Coronary Intervention / Oksidovani Lipoprotein Niske Gustine I Visokosenzitivni C-Reaktivni Protein Kod Nedijabetičara, Predijabetičara I Dijabetičara U Akutnoj Fazi Prvog Infarkta Miokarda Lečenog Primarnom Perkutanom Koronarnom Intervencijom

2015 ◽  
Vol 34 (2) ◽  
pp. 160-169 ◽  
Author(s):  
Danijela Trifunović ◽  
Sanja Stanković ◽  
Jelena Marinković ◽  
Marko Banović ◽  
Nina Đukanović ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Coronary Intervention ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Percutaneous Coronary ◽  
Hs Crp

Summary Background: Oxidized low density lipoprotein (ox-LDL) and high-sensitive C-reactive protein (hs-CRP) are elevated in diabetes mellitus (DM) and associated with accelerated atherosclerosis. Little is known about their dynamics in the acute phase of ST segment elevation myocardial infarction (STEMI), especially in relation to the presence of DM and pre-diabetes (pre-DM). This study aimed to analyze timedependent changes in ox-LDL and hs-CRP regarding the presence of pre-DM and DM in STEMI patients treated by primary percutaneous coronary intervention (pPCI). Methods: In 103 consecutive patients with the first anterior STEMI ox-LDL and hs-CRP were measured before pPCI, on day 2 and day 7 after pPCI. Results: Patients were classified into: non-diabetics, pre-diabetics and diabetics. In each group the maximal ox-LDL concentration was found on admission, decreased on day 2 and reached the lowest values on day 7 (p<0.001). Diabetics had the highest ox-LDL concentrations compared to pre-diabetics and non-diabetics (on admission: p=0.028, on day 2: p=0.056, on day 7: p=0.004). hs-CRP concentration rose from admission, reached its peak on day 2 and decreased on day 7, in each group (p<0.001). Significant differences in hs-CRP concentrations were found between non-diabetics and pre-diabetics on admission (p=0.018) and day 2 (p=0.026). In a multivariate analysis DM was an independent determinant of high ox-LDL concentrations. Both ox-LDL and hs-CRP significantly correlated with Killip class, left ventricular ejection fraction, NT-proBNP and peak troponin I. Conclusions: In patients with the first STEMI treated by pPCI there were significant differences in ox-LDL and hs-CRP concentrations between non-diabetics, pre-diabetics and diabetics. Ox-LDL and hs-CRP concentrations were related to heart failure parameters.

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