Lipid Profiling in Malignant Mesothelioma Reveals Promising Signatures for Diagnosis and Prognosis: A Plasma-Based LC-MS Lipidomics Study

Objectives: The objective of this study is to evaluate the diagnosis and prognosis of malignant mesothelioma of the tunica vaginalis testis through an additional 6 patients with urogenital mesothelioma.Methods: Six patients with urogenital mesothelioma who underwent adequate surgical procedures and histopathologic analysis from 1990 to 2009 were identified and retrospectively reviewed.Results: Six patients between the ages of 26 and 78 years with urogenital mesothelioma, 5 of which originated in the scrotum and 1 in the spermatic cord. Histopathologic analysis showed that CK5/6 and calretinin were positive in all cases, 5 cases were positive for vimentin, and 1 case showed focal weak positive reaction with MOC3, but none of the cases stained for CEA or CD15. The overall recurrence rate of urogenital mesothelioma after surgery was 5/6, including local recurrences and fatalities due to tumour.Conclusions: In cases of mesothelioma of the tunica vaginalis testis, the histopathologic markers we chose helped conﬁrm the histopathological diagnosis; adequate surgical procedures are typically not curative, and this tumour is often fatal.

Download Full-text

Value of morphometry, texture analysis, densitometry, and histometry in the differential diagnosis and prognosis of malignant mesothelioma

The Journal of Pathology ◽

10.1002/(sici)1096-9896(199912)189:4<581::aid-path464>3.0.co;2-p ◽

1999 ◽

Vol 189 (4) ◽

pp. 581-589 ◽

Cited By ~ 17

Author(s):

Barbara Weyn ◽

Gert Van De Wouwer ◽

Marek Koprowski ◽

Andr� Van Daele ◽

Karl Dhaene ◽

...

Keyword(s):

Differential Diagnosis ◽

Texture Analysis ◽

Malignant Mesothelioma ◽

Diagnosis And Prognosis

Download Full-text

Morphologic differences between abdominal and inguinal testes in stallions

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100128389 ◽

1987 ◽

Vol 45 ◽

pp. 820-821

Author(s):

F. Al-Bagdadi ◽

D. Hoyt ◽

P. Karns ◽

G. Martin ◽

M. Memon ◽

...

Keyword(s):

Carcinoma Cells ◽

Genital System ◽

Diagnosis And Prognosis ◽

Male Genital System ◽

Morphological Differences ◽

Hormone Imbalance ◽

Made In ◽

Male Genital

The most frequently occuring abnormality of the male genital system in mammals is the failure of one or both testes to descend into the scrotum. The reasons for abdominal or inguinal retention of testes could be anatomic malformation, faulty development or hormone imbalance.Cryptorchidism has been associated with either greatly reduced or absent spermatogenesis (Kaueakami et al, 1984), and being a source of neoplasia. According to Stick (1980), germinal carcinoma cells have been believed to be the cause of teratomas in equine cryptorchid testicles. Neoplasia has been reported in descended testes of unilateral cryptorchid patients (Martin et al, 1981).No distinction has been made in relating the problem of cryptorchid testes to inguinal or abdominal retention. The purpose of this study is to record the morphological differences between inguinal and abdominal cryptorchid testes as an aid in diagnosis and prognosis.

Download Full-text

Ultrastructural diagnosis of peritoneal malignant mesothelioma

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100168906 ◽

1994 ◽

Vol 52 ◽

pp. 234-235

Author(s):

S. Siew

Keyword(s):

Malignant Mesothelioma ◽

Common Type ◽

Abdominal Discomfort ◽

The Body ◽

Metastatic Adenocarcinoma ◽

Common Site ◽

Primary Malignancy ◽

Peritoneal Implant ◽

Morphological Diagnosis ◽

Malignant Neoplasia

Mesothelial cells constitute the lining of the three serous sacs of the body i.e. the pleura, pericardium and peritoneum. The more common type of malignant neoplasia of the serous sacs is seeding by metastatic tumors and primary malignancy of the mesothelium is unusual. Of the three sacs, the pleura is the most common site of malignant mesothelioma. Involvement of the peritoneum is extremely rare.We report 3 cases of malignant mesothelioma of the peritoneum. All of them were female. Their ages were 57, 67 and 72 years, respectively. The patients presented with abdominal discomfort and/or ascites. The extent of the tumors ranged from a peritoneal implant to widespread infiltration of the peritoneum and omentum. Histologic examination in Case 1 showed the presence of a diffusely infiltrating papillary mesothelioma without a sarcomatoid component. A mesodermal element was present in the other two cases. In order to establish a morphological diagnosis of malignant mesothelioma, the possibility has to be excluded of a metastatic adenocarcinoma.

Download Full-text

The miR-21 potential of serving as a biomarker for liver diseases in clinical practice

Biochemical Society Transactions ◽

10.1042/bst20200653 ◽

2020 ◽

Vol 48 (5) ◽

pp. 2295-2305

Author(s):

Jiawei Zhang ◽

Dandan Li ◽

Rui Zhang ◽

Peng Gao ◽

Rongxue Peng ◽

...

Keyword(s):

Clinical Practice ◽

Liver Diseases ◽

Hepatic Disease ◽

Noninvasive Detection ◽

Diagnosis And Prognosis ◽

Expected Performance ◽

Potential Biomarker ◽

Disease Condition ◽

Complex Regulatory Network

The role of miR-21 in the pathogenesis of various liver diseases, together with the possibility of detecting microRNA in the circulation, makes miR-21 a potential biomarker for noninvasive detection. In this review, we summarize the potential utility of extracellular miR-21 in the clinical management of hepatic disease patients and compared it with the current clinical practice. MiR-21 shows screening and prognostic value for liver cancer. In liver cirrhosis, miR-21 may serve as a biomarker for the differentiating diagnosis and prognosis. MiR-21 is also a potential biomarker for the severity of hepatitis. We elucidate the disease condition under which miR-21 testing can reach the expected performance. Though miR-21 is a key regulator of liver diseases, microRNAs coordinate with each other in the complex regulatory network. As a result, the performance of miR-21 is better when combined with other microRNAs or classical biomarkers under certain clinical circumstances.

Download Full-text