The topical drug delivery systems available for the treatment have several disadvantages like greasiness, inconvenient to
store and requires applicator or use of fingertip, which may lead to contamination. Therefore, it was found essential to find an
alternative to counter all the above disadvantages effectively and hence in the present work, formulation and development of
medicated sticks has been planned with the drug, Soframycin Sulfate that has anti bacterial and anti fungal activity. In order
to formulate an effective and efficient topical preparation, consideration must be given to the intended purpose. This is directly
concerned with the site of action and the desired effect of the preparation. The most common form of chromomycosis is known
as chromoblastomycosis or verucous dermatitis the lesions consist of warty cutaneous nodules which resemble the florest of
cauliflower. The disease is usually confined to the subcutaneous tissue of the feet and lower legs. The topical drug delivery
systems available for the treatment have several disadvantages like greasiness, inconvenient to store and requires applicator
or use of fingertip, which may lead to contamination. Therefore, it was found essential to find an alternative to counter all the
above disadvantages effectively and hence in the present work, formulation and development of medicated sticks has been
planned with the drug, Soframycin Sulfate that has anti bacterial and anti fungal activity. The preparation and characterization
of medicated sticks was carried out in different phases. Phase I studies includes preparation and evaluation medicated derma
sticks using the ointment bases with varied concentrations of waxes and incorporation of medicament in the optimized formula
by heating and congealing process. Phase II studies includes characterization of prepared medicated sticks for weight variation,
thickness, length, size, shape and drug content uniformity. Phase III studies involves in vitro drug diffusion studies by using
prehydrated cellophane membrane for 160 minutes in pH 6.4 phosphate buffer. Phase IV studies includes anti microbial studies
of prepared formulations by cup plate method. Phase V studies includes Stability studies conducted for a period of 3 weeks and
FT-IR Spectral analysis conducted. Phase VI studies includes Primary skin irritation studies carried out on rabbits and guinea
pigs and in healthy human volunteers showed no sensitization and edema on skin after 72 hrs of application.