scholarly journals Nfya-1 functions as a substrate of ERK-MAP kinase during Caenorhabditis elegans vulval development

2021 ◽  
pp. 203757
Author(s):  
Segen Aklilu ◽  
Michelle Krakowiak ◽  
Abena Frempong ◽  
Katherine Wilson ◽  
Christy Powers ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Map Kinase ◽  
Vulval Development

scholarly journals Transcriptional network underlying Caenorhabditis elegans vulval development

2005 ◽  
Vol 102 (14) ◽  
pp. 4972-4977 ◽  
Author(s):  
T. Inoue ◽  
M. Wang ◽  
T. O. Ririe ◽  
J. S. Fernandes ◽  
P. W. Sternberg
Keyword(s):  
Caenorhabditis Elegans ◽  
Transcriptional Network ◽  
Vulval Development

scholarly journals A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans.

1994 ◽  
Vol 8 (2) ◽  
pp. 160-173 ◽  
Author(s):  
M R Lackner ◽  
K Kornfeld ◽  
L M Miller ◽  
H R Horvitz ◽  
S K Kim
Keyword(s):  
Caenorhabditis Elegans ◽  
Map Kinase ◽  
Cell Fates

scholarly journals The MADD-3 LAMMER Kinase Interacts with a p38 MAP Kinase Pathway to Regulate the Display of the EVA-1 Guidance Receptor in Caenorhabditis elegans

PLoS Genetics ◽  
2016 ◽  
Vol 12 (4) ◽  
pp. e1006010 ◽  
Author(s):  
Serena A. D’Souza ◽  
Luckshi Rajendran ◽  
Rachel Bagg ◽  
Louis Barbier ◽  
Derek M. van Pel ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Caenorhabditis Elegans ◽  
Map Kinase ◽  
Motor Neurons ◽  
Leading Edge ◽  
P38 Map Kinase ◽  
Endosomal Trafficking ◽  
Guidance Cue ◽  
Map Kinase Pathway ◽  
Kinase Pathway

The proper display of transmembrane receptors on the leading edge of migrating cells and cell extensions is essential for their response to guidance cues. We previously discovered that MADD-4, which is an ADAMTSL secreted by motor neurons in Caenorhabditis elegans, interacts with an UNC-40/EVA-1 co-receptor complex on muscles to attract plasma membrane extensions called muscle arms. In nematodes, the muscle arm termini harbor the post-synaptic elements of the neuromuscular junction. Through a forward genetic screen for mutants with disrupted muscle arm extension, we discovered that a LAMMER kinase, which we call MADD-3, is required for the proper display of the EVA-1 receptor on the muscle’s plasma membrane. Without MADD-3, EVA-1 levels decrease concomitantly with a reduction of the late-endosomal marker RAB-7. Through a genetic suppressor screen, we found that the levels of EVA-1 and RAB-7 can be restored in madd-3 mutants by eliminating the function of a p38 MAP kinase pathway. We also found that EVA-1 and RAB-7 will accumulate in madd-3 mutants upon disrupting CUP-5, which is a mucolipin ortholog required for proper lysosome function. Together, our data suggests that the MADD-3 LAMMER kinase antagonizes the p38-mediated endosomal trafficking of EVA-1 to the lysosome. In this way, MADD-3 ensures that sufficient levels of EVA-1 are present to guide muscle arm extension towards the source of the MADD-4 guidance cue.

scholarly journals Computational insights into Caenorhabditis elegans vulval development

2005 ◽  
Vol 102 (6) ◽  
pp. 1951-1956 ◽  
Author(s):  
J. Fisher ◽  
N. Piterman ◽  
E. J. A. Hubbard ◽  
M. J. Stern ◽  
D. Harel
Keyword(s):  
Caenorhabditis Elegans ◽  
Vulval Development

The terminal differentiation factor LIN-29 is required for proper vulval morphogenesis and egg laying in Caenorhabditis elegans

Development ◽  
1997 ◽  
Vol 124 (21) ◽  
pp. 4333-4342 ◽  
Author(s):  
J.C. Bettinger ◽  
S. Euling ◽  
A.E. Rougvie
Keyword(s):  
Caenorhabditis Elegans ◽  
Terminal Differentiation ◽  
Egg Laying ◽  
Small Subset ◽  
Wild Type ◽  
Vulval Development ◽  
Genetic Mosaics ◽  
Hypodermal Cell ◽  
Heterochronic Gene ◽  
Final Molt

Caenorhabditis elegans vulval development culminates during exit from the L4-to-adult molt with the formation of an opening through the adult hypodermis and cuticle that is used for egg laying and mating. Vulva formation requires the heterochronic gene lin-29, which triggers hypodermal cell terminal differentiation during the final molt. lin-29 mutants are unable to lay eggs or mate because no vulval opening forms; instead, a protrusion forms at the site of the vulva. We demonstrate through analysis of genetic mosaics that lin-29 is absolutely required in a small subset of lateral hypodermal seam cells, adjacent to the vulva, for wild-type vulva formation and egg laying. However, lin-29 function is not strictly limited to the lateral hypodermis. First, LIN-29 accumulates in many non-hypodermal cells with known roles in vulva formation or egg laying. Second, animals homozygous for one lin-29 allele, ga94, have the vulval defect and cannot lay eggs, despite having a terminally differentiated adult lateral hypodermis. Finally, vulval morphogenesis and egg laying requires lin-29 activity within the EMS lineage, a lineage that does not generate hypodermal cells.

scholarly journals Cell fate-specific regulation of EGF receptor trafficking during Caenorhabditis elegans vulval development

2006 ◽  
Vol 25 (11) ◽  
pp. 2347-2357 ◽  
Author(s):  
Attila Stetak ◽  
Erika Fröhli Hoier ◽  
Assunta Croce ◽  
Giuseppe Cassata ◽  
Pier Paolo Di Fiore ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Cell Fate ◽  
Egf Receptor ◽  
Receptor Trafficking ◽  
Vulval Development ◽  
Specific Regulation

scholarly journals OSM-11 Facilitates LIN-12 Notch Signaling during Caenorhabditis elegans Vulval Development

PLoS Biology ◽  
2008 ◽  
Vol 6 (8) ◽  
pp. e196 ◽  
Author(s):  
Hidetoshi Komatsu ◽  
Michael Y Chao ◽  
Jonah Larkins-Ford ◽  
Mark E Corkins ◽  
Gerard A Somers ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Notch Signaling ◽  
Vulval Development

MAP kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans

Nature ◽  
10.1038/21666 ◽  
1999 ◽  
Vol 399 (6738) ◽  
pp. 793-797 ◽  
Author(s):  
Marc D. Meneghini ◽  
Tohru Ishitani ◽  
J. Clayton Carter ◽  
Naoki Hisamoto ◽  
Jun Ninomiya-Tsuji ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Map Kinase ◽  
Wnt Pathways
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