Bioengineered PLGA-chitosan nanoparticles for brain targeted intranasal delivery of antiepileptic TRH analogues

2018 ◽  
Vol 346 ◽  
pp. 630-639 ◽  
Author(s):  
Sarabjit Kaur ◽  
Priya Manhas ◽  
Anuradha Swami ◽  
Ranjana Bhandari ◽  
Krishna K. Sharma ◽  
...  
Keyword(s):  
Chitosan Nanoparticles ◽  
Intranasal Delivery ◽  
Trh Analogues

N,N,N-Trimethyl chitosan nanoparticles for controlled intranasal delivery of HBV surface antigen

2012 ◽  
Vol 89 (4) ◽  
pp. 1289-1297 ◽  
Author(s):  
Ramesh Subbiah ◽  
Prakash Ramalingam ◽  
Subramaniyan Ramasundaram ◽  
Do Yang Kim ◽  
Kwideok Park ◽  
...  
Keyword(s):  
Surface Antigen ◽  
Chitosan Nanoparticles ◽  
Intranasal Delivery ◽  
Trimethyl Chitosan

Formulation and biopharmaceutical evaluation of risperidone-loaded chitosan nanoparticles for intranasal delivery

2019 ◽  
Vol 45 (8) ◽  
pp. 1342-1350 ◽  
Author(s):  
Rajalakshmi Rukmangathen ◽  
Indira Muzib Yallamalli ◽  
Prasanna Raju Yalavarthi
Keyword(s):  
Chitosan Nanoparticles ◽  
Intranasal Delivery

scholarly journals Evaluation of Neuroprotective Effect of Thymoquinone Nanoformulation in the Rodent Cerebral Ischemia-Reperfusion Model

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Xiao-Yu Xiao ◽  
Ying-Xian Zhu ◽  
Ju-Yuan Bu ◽  
Guo-Wei Li ◽  
Jian-Hui Zhou ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Ischemia Reperfusion ◽  
Chitosan Nanoparticles ◽  
Intranasal Delivery ◽  
Cerebral Ischemia Reperfusion ◽  
Biochemical Studies ◽  
Neuroprotective Efficacy ◽  
The Brain

The purpose of the present study was to evaluate the neuroprotective efficacy of optimized thymoquinone loaded PLGA-chitosan nanoparticles delivered via nose to brain route in the rodent cerebral ischemia-reperfusion model. The neuroprotective efficacy of the optimized thymoquinone loaded PLGA-chitosan nanoparticles was evaluated in middle cerebral artery occluded rats by various pharmacodynamic and biochemical studies. The pharmacokinetics of thymoquinone loaded PLGA-chitosan nanoparticles in the brain and blood plasma together with qualitative localization of florescent labelled PLGA-chitosan nanoparticles in brain tissues were also determined. Intranasal delivery of optimized thymoquinone loaded PLGA-chitosan nanoparticles (183.5±8.2 nm,33.63±2.25 mV) to brain significantly reduced the ischemia infarct volume and enhanced the locomotor activity and grip strength in the middle cerebral artery occluded rats. Biochemical studies showed that intranasal delivery of thymoquinone loaded PLGA-chitosan nanoparticles significantly reduced the lipid peroxidation but elevated the glutathione, catalase, and superoxide dismutase in the brain of middle cerebral artery occluded rats. The pharmacokinetic and localization studies showed that thymoquinone loaded PLGA-chitosan nanoparticles facilitated the delivery of thymoquinone to brain by intranasal nose to brain transport pathways and enhanced their pharmacokinetic profile in brain tissues. Thus, intranasal delivery of thymoquinone loaded PLGA-chitosan nanoparticles to brain could be potentially used for the neuroprotection and treatment of cerebral ischemia.

scholarly journals Data on enrichment of chitosan nanoparticles for intranasal delivery of oligonucleotides to the brain

Data in Brief ◽  
2020 ◽  
Vol 28 ◽  
pp. 105093
Author(s):  
Vasyl Sava ◽  
Oksana Fihurka ◽  
Anastasia Khvorova ◽  
Juan Sanchez-Ramos
Keyword(s):  
Chitosan Nanoparticles ◽  
Intranasal Delivery ◽  
The Brain

Intranasal delivery of phenytoin-loaded nanoparticles to the brain suppresses pentylenetetrazol-induced generalized tonic clonic seizures in epilepsy mouse model

2021 ◽  
Author(s):  
Amal Yousfan ◽  
Noelia Rubio Carrero ◽  
Mohamad Al-Ali ◽  
Abdul Hakim Nattouf ◽  
Houmam Kafa
Keyword(s):  
Mouse Model ◽  
Mouse Brain ◽  
Chitosan Nanoparticles ◽  
Intranasal Delivery ◽  
Anti Epileptic Drug ◽  
Clonic Seizures ◽  
The Brain

In this work we describe the preparation and characterization of lecithin-chitosan nanoparticles (L10Ci+), and investigate their ability to deliver the anti-epileptic drug phenytoin (PHT) to mouse brain following intranasal (IN)...

Preparation, Characterization and Evaluation of Bromocriptine Loaded Chitosan Nanoparticles for Intranasal Delivery

2012 ◽  
Vol 4 (9) ◽  
pp. 949-960 ◽  
Author(s):  
Md Shadab ◽  
Manish Kumar ◽  
Sanjula Baboota ◽  
Jasjeet Kaur Sahni ◽  
Javed Ali
Keyword(s):  
Chitosan Nanoparticles ◽  
Intranasal Delivery

scholarly journals Intranasal Administration of RBD Nanoparticles Confers Induction of Mucosal and Systemic Immunity against SARS-CoV-2

Vaccines ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 768
Author(s):  
Tuksin Jearanaiwitayakul ◽  
Mathurin Seesen ◽  
Runglawan Chawengkirttikul ◽  
Jitra Limthongkul ◽  
Suttikarn Apichirapokey ◽  
...  
Keyword(s):  
Mucosal Immunity ◽  
Neutralizing Antibodies ◽  
Chitosan Nanoparticles ◽  
Intranasal Delivery ◽  
Intranasal Route ◽  
Cd8 Cells ◽  
Upper Respiratory ◽  
Sterilizing Immunity ◽  
Shed Light ◽  
Systemic Compartment

Mucosal immunity plays a significant role in host defense against viruses in the respiratory tract. Because the upper respiratory airway is a primary site of SARS-CoV-2 entry, immunization at the mucosa via the intranasal route could potentially lead to induction of local sterilizing immunity that protects against SARS-CoV-2 infection. In this study, we evaluated the immunogenicity of a receptor-binding domain (RBD) of SARS-CoV-2 spike glycoprotein loaded into N,N,N-trimethyl chitosan nanoparticles (RBD-TMC NPs). We showed that intranasal delivery of RBD-TMC NPs into mice induced robust local mucosal immunity, as evidenced by the presence of IgG and IgA responses in BALs and the lungs of immunized mice. Furthermore, mice intranasally administered with this platform of immunogens developed robust systemic antibody responses including serum IgG, IgG1, IgG2a, IgA and neutralizing antibodies. In addition, these immunized mice had significantly higher levels of activated splenic CD4+ and CD8+ cells compared with those that were administered with soluble RBD immunogen. Collectively, these findings shed light on an alternative route of vaccination that mimics the natural route of SARS-CoV-2 infection. This route of administration stimulated not only local mucosal responses but also the systemic compartment of the immune system.

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