Compartmentalized cAMP signaling in cardiac ventricular myocytes

2021 ◽  
pp. 110172
Author(s):  
Shailesh R. Agarwal ◽  
Rinzhin T. Sherpa ◽  
Karni S. Moshal ◽  
Robert D. Harvey
Keyword(s):  
Ventricular Myocytes ◽  
Camp Signaling ◽  
Cardiac Ventricular Myocytes

scholarly journals Dual role of junctin in the regulation of ryanodine receptors and calcium release in cardiac ventricular myocytes

2011 ◽  
Vol 589 (24) ◽  
pp. 6063-6080 ◽  
Author(s):  
Beth A. Altschafl ◽  
Demetrios A. Arvanitis ◽  
Oscar Fuentes ◽  
Qunying Yuan ◽  
Evangelia G. Kranias ◽  
...  
Keyword(s):  
Calcium Release ◽  
Ventricular Myocytes ◽  
Ryanodine Receptors ◽  
Dual Role ◽  
Cardiac Ventricular Myocytes

scholarly journals Inhibitory effect of aprindine on Na+ /Ca2+ exchange current in guinea-pig cardiac ventricular myocytes

2002 ◽  
Vol 136 (3) ◽  
pp. 361-366 ◽  
Author(s):  
Yasuhide Watanabe ◽  
Takahiro Iwamoto ◽  
Munekazu Shigekawa ◽  
Junko Kimura
Keyword(s):  
Guinea Pig ◽  
Ventricular Myocytes ◽  
Inhibitory Effect ◽  
Exchange Current ◽  
Cardiac Ventricular Myocytes

The Chemical Compound PTC124 Does Not Affect Cellular Electrophysiology of Cardiac Ventricular Myocytes

2011 ◽  
Vol 26 (1) ◽  
pp. 41-45 ◽  
Author(s):  
Tamara T. Koopmann ◽  
Arie O. Verkerk ◽  
Connie R. Bezzina ◽  
Jacques M. T. de Bakker ◽  
Arthur A. M. Wilde
Keyword(s):  
Chemical Compound ◽  
Ventricular Myocytes ◽  
Cellular Electrophysiology ◽  
Cardiac Ventricular Myocytes

scholarly journals Inhibitory Effect of Cibenzoline on Na+/Ca2+ Exchange Current in Guinea-Pig Cardiac Ventricular Myocytes

2012 ◽  
Vol 120 (1) ◽  
pp. 59-62 ◽  
Author(s):  
Tomomi Yamakawa ◽  
Yasuhide Watanabe ◽  
Hiroshi Watanabe ◽  
Junko Kimura
Keyword(s):  
Guinea Pig ◽  
Ventricular Myocytes ◽  
Inhibitory Effect ◽  
Exchange Current ◽  
Cardiac Ventricular Myocytes

scholarly journals Modulation of voltage-dependent sodium and potassium currents by charged amphiphiles in cardiac ventricular myocytes. Effects via modification of surface potential.

1993 ◽  
Vol 101 (3) ◽  
pp. 355-375 ◽  
Author(s):  
S Ji ◽  
J N Weiss ◽  
G A Langer
Keyword(s):  
Steady State ◽  
Surface Potential ◽  
Ventricular Myocytes ◽  
Potassium Currents ◽  
Surface Charges ◽  
Negative Direction ◽  
Voltage Dependent ◽  
Kinetics Of ◽  
Sodium And Potassium ◽  
Cardiac Ventricular Myocytes

Modulation of voltage-dependent sodium and potassium currents by charged amphiphiles was investigated in cardiac ventricular myocytes using the patch-clamp technique. Negatively charged sodium dodecylsulfate (SDS) increased amplitude of INa, whereas positively charged dodecyltrimethylammonium (DDTMA) decreased INa. Furthermore, SDS shifted the steady-state activation and inactivation of INa in the negative direction, whereas DDTMA shifted the curves in the opposite direction. These shifts provided an explanation for the changes in current amplitude. Activation and inactivation kinetics of INa were accelerated by SDS but slowed by DDTMA. These changes in both steady-state gating and kinetics of INa are consistent with a decrease of the intramembrane field by SDS and an increase of the field by DDTMA due to an alteration of surface potential after their insertion into the outer monolayer of the sarcolemma. The effect of SDS on the steady-state inactivation of INa was concentration dependent and partially reversed by screening surface charges with increased extracellular [Ca2+]. These amphiphiles also altered the activation of the delayed rectifier K+ current (IK,del), producing a shift in the negative direction by SDS but in the positive direction by DDTMA. These results suggest that the insertion of charged amphiphiles into the cell membrane alters the behavior of voltage-dependent INa and IK,del by changing the surface charge density, and consequently the surface potential and implies, although indirectly, that the lipid surface charges are important to the voltage-dependent gating of these channels.

Sign in / Sign up

Export Citation Format

Share Document