Preparation of amorphous drug nanoparticles by high-gravity reactive precipitation technique

2016 ◽  
Vol 104 ◽  
pp. 253-261 ◽  
Author(s):  
Zhi-Bing Zhang ◽  
Miao-Ling Xie ◽  
Yun-Yun Kuang ◽  
Jie-Xin Wang ◽  
Yuan Le ◽  
...  
Keyword(s):  
High Gravity ◽  
Drug Nanoparticles ◽  
Precipitation Technique ◽  
Amorphous Drug

Amorphization Strategy Affects the Stability and Supersaturation Profile of Amorphous Drug Nanoparticles

2014 ◽  
Vol 11 (5) ◽  
pp. 1611-1620 ◽  
Author(s):  
Wean Sin Cheow ◽  
Tie Yi Kiew ◽  
Yue Yang ◽  
Kunn Hadinoto
Keyword(s):  
Drug Nanoparticles ◽  
The Stability ◽  
Amorphous Drug

Design of Potent Amorphous Drug Nanoparticles for Rapid Generation of Highly Supersaturated Media

2007 ◽  
Vol 4 (5) ◽  
pp. 782-793 ◽  
Author(s):  
Michal E. Matteucci ◽  
Blair K. Brettmann ◽  
True L. Rogers ◽  
Edmund J. Elder ◽  
Robert O. Williams ◽  
...  
Keyword(s):  
Drug Nanoparticles ◽  
Rapid Generation ◽  
Amorphous Drug

An inert 3D emulsification device for individual precipitation and concentration of amorphous drug nanoparticles

Lab on a Chip ◽  
2018 ◽  
Vol 18 (4) ◽  
pp. 627-638 ◽  
Author(s):  
T. Lorenz ◽  
S. Bojko ◽  
H. Bunjes ◽  
A. Dietzel
Keyword(s):  
Specific Surface ◽  
Water Soluble ◽  
Poorly Water Soluble Drugs ◽  
Drug Nanoparticles ◽  
Novel Approach ◽  
Water Soluble Drugs ◽  
Poorly Water Soluble ◽  
Amorphous Drug

Nanosizing increases the specific surface of drug particles, leading to faster dissolution inside the organism and improving the bioavailability of poorly water-soluble drugs. A novel approach for the preparation of drug nanoparticles in water using chemically inert microfluidic emulsification devices is presented.

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