Formation mechanism of amorphous drug nanoparticles using the antisolvent precipitation method elucidated by varying the preparation temperature

2021 ◽  
pp. 121210
Author(s):  
Chikako Morikawa ◽  
Keisuke Ueda ◽  
Masaki Omori ◽  
Kenjirou Higashi ◽  
Kunikazu Moribe
Keyword(s):  
Formation Mechanism ◽  
Precipitation Method ◽  
Preparation Temperature ◽  
Drug Nanoparticles ◽  
Antisolvent Precipitation ◽  
Amorphous Drug

A new approach for the stabilization of amorphous drug nanoparticles during continuous antisolvent precipitation

2019 ◽  
Vol 361 ◽  
pp. 428-438 ◽  
Author(s):  
Holger Trzenschiok ◽  
Monica Distaso ◽  
Wolfgang Peukert
Keyword(s):  
New Approach ◽  
Drug Nanoparticles ◽  
Antisolvent Precipitation ◽  
Amorphous Drug

scholarly journals Investigating the Feasibility of Mefenamic Acid Nanosuspension for Pediatric Delivery: Preparation, Characterization, and Role of Excipients

Processes ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 574
Author(s):  
Nikhat Perween ◽  
Sultan Alshehri ◽  
T. S. Easwari ◽  
Vivek Verma ◽  
Md. Faiyazuddin ◽  
...  
Keyword(s):  
Particle Size ◽  
Mefenamic Acid ◽  
Hydroxypropyl Methylcellulose ◽  
Sodium Dodecyl ◽  
Aqueous Solubility ◽  
Oral Route ◽  
Precipitation Method ◽  
Antisolvent Precipitation

Molecules with poor aqueous solubility are difficult to formulate using conventional approaches and are associated with many formulation delivery issues. To overcome these obstacles, nanosuspension technology can be one of the promising approaches. Hence, in this study, the feasibility of mefenamic acid (MA) oral nanosuspension was investigated for pediatric delivery by studying the role of excipients and optimizing the techniques. Nanosuspensions of MA were prepared by adopting an antisolvent precipitation method, followed by ultrasonication with varying concentrations of polymers, surfactants, and microfluidics. The prepared nanosuspensions were evaluated for particle size, morphology, and rheological measures. Hydroxypropyl methylcellulose (HPMC) with varying concentrations and different stabilizers including Tween® 80 and sodium dodecyl sulfate (SLS) were used to restrain the particle size growth of the developed nanosuspension. The optimized nanosuspension formula was stable for more than 3 weeks and showed a reduced particle size of 510 nm with a polydispersity index of 0.329. It was observed that the type and ratio of polymer stabilizers were responsive on the particle contour and dimension and stability. We have developed a biologically compatible oral nanoformulation for a first-in-class drug beautifully designed for pediatric delivery that will be progressed toward further in vivo enabling studies. Finally, the nanosuspension could be considered a promising carrier for pediatric delivery of MA through the oral route with enhanced biological impact.

scholarly journals Emamectin benzoate-loaded zein nanoparticles produced by antisolvent precipitation method

2021 ◽  
Vol 94 ◽  
pp. 107020
Author(s):  
Bo Cui ◽  
Jing Li ◽  
Ziyang Lai ◽  
Fei Gao ◽  
Zhanghua Zeng ◽  
...  
Keyword(s):  
Precipitation Method ◽  
Emamectin Benzoate ◽  
Antisolvent Precipitation

Erratum to “Effect of low temperature on formation mechanism of calcium phosphate nano powder via precipitation method” [Adv. Powder Technol. 23 (2012) 744–751]

2017 ◽  
Vol 28 (2) ◽  
pp. 686
Author(s):  
P. Moghimian ◽  
M.H. Khosravi ◽  
A. Najafi ◽  
S. Afshar ◽  
J. Javadpour ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Low Temperature ◽  
Formation Mechanism ◽  
Precipitation Method ◽  
Nano Powder

scholarly journals Preparation and characterization of domperidone nanoparticles for dissolution improvement

2018 ◽  
Vol 27 (1) ◽  
pp. 39-52
Author(s):  
Mohammed Sabar Al-lami ◽  
Malath H. Oudah ◽  
Firas A. Rahi
Keyword(s):  
Particle Size ◽  
Average Particle Size ◽  
In Vitro Release ◽  
Methyl Cellulose ◽  
Precipitation Method ◽  
Average Particle ◽  
Antisolvent Precipitation ◽  
Stirring Time

This study was carried out to prepare and characterize domperidone nanoparticles to enhance solubility and the release rate. Domperidone is practically insoluble in water and has low and an erratic bioavailability range from 13%-17%. The domperidone nanoparticles were prepared by solvent/antisolvent precipitation method at different polymer:drug ratios of 1:1 and 2:1 using different polymers and grades of poly vinyl pyrolidone, hydroxy propyl methyl cellulose and sodium carboxymethyl cellulose as stabilizers. The effect of polymer type, ratio of polymer:drug, solvent:antisolvent ratio, stirring rate and stirring time on the particle size, were investigated and found to have a significant (p? 0.05) effect on particle size. The best formula was obtained with lowest average particle size of 84.05. This formula was studied for compatibility by FTIR and DSC, surface morphology by FESEM and crystalline state by XRPD. Then domperidone nanoparticles were formulated into a simple capsule dosage form in order to study of the in vitro release of drug from nanoparticles in comparison raw drug and mixture of polymer:drug ratios of 2:1. The release of domperidone from best formula was highly improved with a significant (p? 0.05) increase.

Effect of low temperature on formation mechanism of calcium phosphate nano powder via precipitation method

2012 ◽  
Vol 23 (6) ◽  
pp. 744-751 ◽  
Author(s):  
P. Moghimian ◽  
A. Najafi ◽  
S. Afshar ◽  
J. Javadpour
Keyword(s):  
Calcium Phosphate ◽  
Low Temperature ◽  
Formation Mechanism ◽  
Precipitation Method ◽  
Nano Powder

scholarly journals Preparation of Drug Nanoparticles by Co-grinding with Cyclodextrin: Formation Mechanism and Factors Affecting Nanoparticle Formation

2007 ◽  
Vol 55 (3) ◽  
pp. 359-363 ◽  
Author(s):  
Arpansiree Wongmekiat ◽  
Yuichi Tozuka ◽  
Kunikazu Moribe ◽  
Toshio Oguchi ◽  
Keiji Yamamoto
Keyword(s):  
Formation Mechanism ◽  
Factors Affecting ◽  
Nanoparticle Formation ◽  
Drug Nanoparticles

Optimized Synthesis of HMX Nanoparticles Using Antisolvent Precipitation Method

2015 ◽  
Vol 33 (4) ◽  
pp. 277-287 ◽  
Author(s):  
Raj Kumar ◽  
Prem Felix Siril ◽  
Pramod Soni
Keyword(s):  
Precipitation Method ◽  
Antisolvent Precipitation

scholarly journals Nanosuspensions of Selexipag: Formulation, Characterization, and in vitro Evaluation

2021 ◽  
Vol 30 (1) ◽  
pp. 144-153
Author(s):  
Rusul M. Alwan ◽  
Nawal A. Rajab
Keyword(s):  
Particle Size ◽  
Dissolution Rate ◽  
In Vitro Dissolution ◽  
Precipitation Method ◽  
Antisolvent Precipitation ◽  
Prostacyclin Receptor ◽  
Pulmonary Arterial ◽  
Formulation Parameters ◽  
Long Acting

Selexipag is an orally selective long-acting prostacyclin receptor agonist, which indicated for the treatment of pulmonary arterial hypertension. It is practically insoluble in water ( class II, according to BCS). This work aims to prepare and optimized Selexipag nanosuspensions to achieve an enhancement in the in vitro dissolution rate. The solvent antisolvent precipitation method was used for the production of nanosuspension, and the effect of formulation parameters (stabilizer type, drug: stabilizer ratio, and use of co-stabilizer) and process parameter (stirring speed) on the particle size and polydispersity index were studied. SLPNS prepared with Soluplus® as amain stabilizer (F15) showed the smallest particle size 47nm with PDI and Zeta potential value of 0.073 and -47mV, respectively. SLPNS exhibited an increase in the dissolution rate in phosphate buffer pH 6.8 (100% drug release during 60 min) compared to the pure drug ( 40% during the same time). This result indicates that SLPNS is an efficient way of improving the dissolution rate.  

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