Amorphization Strategy Affects the Stability and Supersaturation Profile of Amorphous Drug Nanoparticles

2014 ◽  
Vol 11 (5) ◽  
pp. 1611-1620 ◽  
Author(s):  
Wean Sin Cheow ◽  
Tie Yi Kiew ◽  
Yue Yang ◽  
Kunn Hadinoto
Keyword(s):  
Drug Nanoparticles ◽  
The Stability ◽  
Amorphous Drug

scholarly journals Development of spray-dried co-precipitate of amorphous celecoxib containing storage and compression stabilizers

2007 ◽  
Vol 57 (3) ◽  
pp. 287-300 ◽  
Author(s):  
Ravindra Dhumal ◽  
Shamkant Shimpi ◽  
Anant Paradkar
Keyword(s):  
Hydrogen Bonding ◽  
Solid Dispersion ◽  
Dissolution Profile ◽  
Scanning Calorimetry ◽  
Unit Operations ◽  
Bonding Interaction ◽  
Amorphous Drugs ◽  
The Stability ◽  
Amorphous Drug ◽  
Spray Dried

Development of spray-dried co-precipitate of amorphous celecoxib containing storage and compression stabilizersThe purpose of this study was to obtain an amorphous system with minimum unit operations that will prevent recrystallization of amorphous drugs since preparation, during processing (compression) and further storage. Amorphous celecoxib, solid dispersion (SD) of celecoxib with polyvinyl pyrrollidone (PVP) and co-precipitate with PVP and carrageenan (CAR) in different ratios were prepared by the spray drying technique and compressed into tablets. Saturation solubility and dissolution studies were performed to differentiate performance after processing. Differential scanning calorimetry and X-ray powder difraction revealed the amorphous form of celecoxib, whereas infrared spectroscopy revealed hydrogen bonding between celecoxib and PVP. The dissolution profile of the solid dispersion and co-precipitate improved compared to celecoxib and amorphous celecoxib. Amorphous celecoxib was not stable on storage whereas the solid dispersion and co-precipitate powders were stable for 3 months. Tablets of the solid dispersion of celecoxib with PVP and physical mixture with PVP and carrageenan showed better resistance to recrystallization than amorphous celecoxib during compression but recrystallized on storage. However, tablets of co-precipitate with PVP and carageenan showed no evidence of crystallinity during stability studies with comparable dissolution profiles. This extraordinary stability of spray-dried co-precipitate tablets may be attributed to the cushioning action provided by the viscoelastic polymer CAR and hydrogen bonding interaction between celecoxib and PVP. The present study demonstrates the synergistic effect of combining two types of stabilizers, PVP and CAR, on the stability of amorphous drug during compression and storage as compared to their effect when used alone.

Design of Potent Amorphous Drug Nanoparticles for Rapid Generation of Highly Supersaturated Media

2007 ◽  
Vol 4 (5) ◽  
pp. 782-793 ◽  
Author(s):  
Michal E. Matteucci ◽  
Blair K. Brettmann ◽  
True L. Rogers ◽  
Edmund J. Elder ◽  
Robert O. Williams ◽  
...  
Keyword(s):  
Drug Nanoparticles ◽  
Rapid Generation ◽  
Amorphous Drug

An inert 3D emulsification device for individual precipitation and concentration of amorphous drug nanoparticles

Lab on a Chip ◽  
2018 ◽  
Vol 18 (4) ◽  
pp. 627-638 ◽  
Author(s):  
T. Lorenz ◽  
S. Bojko ◽  
H. Bunjes ◽  
A. Dietzel
Keyword(s):  
Specific Surface ◽  
Water Soluble ◽  
Poorly Water Soluble Drugs ◽  
Drug Nanoparticles ◽  
Novel Approach ◽  
Water Soluble Drugs ◽  
Poorly Water Soluble ◽  
Amorphous Drug

Nanosizing increases the specific surface of drug particles, leading to faster dissolution inside the organism and improving the bioavailability of poorly water-soluble drugs. A novel approach for the preparation of drug nanoparticles in water using chemically inert microfluidic emulsification devices is presented.

Preparation of amorphous drug nanoparticles by high-gravity reactive precipitation technique

2016 ◽  
Vol 104 ◽  
pp. 253-261 ◽  
Author(s):  
Zhi-Bing Zhang ◽  
Miao-Ling Xie ◽  
Yun-Yun Kuang ◽  
Jie-Xin Wang ◽  
Yuan Le ◽  
...  
Keyword(s):  
High Gravity ◽  
Drug Nanoparticles ◽  
Precipitation Technique ◽  
Amorphous Drug

A new approach for the stabilization of amorphous drug nanoparticles during continuous antisolvent precipitation

2019 ◽  
Vol 361 ◽  
pp. 428-438 ◽  
Author(s):  
Holger Trzenschiok ◽  
Monica Distaso ◽  
Wolfgang Peukert
Keyword(s):  
New Approach ◽  
Drug Nanoparticles ◽  
Antisolvent Precipitation ◽  
Amorphous Drug
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