scholarly journals Short Disease Duration Does Not Always Indicate Early Crohn’s Disease

2019 ◽  
Vol 17 (8) ◽  
pp. 1646 ◽  
Author(s):  
Iago Rodríguez-Lago ◽  
Manuel Barreiro-de Acosta
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Duration ◽  
Short Disease Duration

scholarly journals Infliximab Preferentially Induces Clinical Remission and Mucosal Healing in Short Course Crohn’s Disease with Luminal Lesions through Balancing Abnormal Immune Response in Gut Mucosa

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Lijuan Yu ◽  
Xuehua Yang ◽  
Lu Xia ◽  
Jie Zhong ◽  
Wensong Ge ◽  
...  
Keyword(s):  
Immune Response ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Clinical Response ◽  
Clinical Remission ◽  
Disease Duration ◽  
Activity Index ◽  
Mucosal Healing ◽  
Short Course ◽  
Short Disease Duration

This study was undertaken to evaluate the efficacy of infliximab (IFX) in treatment of Crohn’s disease (CD) patients. 106 CD patients were undergoing treatment with IFX from five hospitals in Shanghai, China. Clinical remission to IFX induction therapy was defined as Crohn’s disease activity index (CDAI) < 150. Clinical response was assessed by a decrease in CDAI ≥ 70, and the failure as a CDAI was not significantly changed or increased. Ten weeks after therapy, 61 (57.5%) patients achieved clinical remission, 17 (16.0%) had clinical response, and the remaining 28 (26.4%) were failed. In remission group, significant changes were observed in CDAI, the Simple Endoscopic Score for Crohn’s Disease (SES-CD), and serum indexes. Patients with short disease duration (22.2 ± 23.2 months) and luminal lesions showed better effects compared to those with long disease duration (71.0 ± 58.2 months) or stricturing and penetrating lesions. IFX markedly downregulated Th1/Th17-mediated immune response but promoted IL-25 production in intestinal mucosa from remission group. No serious adverse events occurred to terminate treatment. Taken together, our studies demonstrated that IFX is efficacious and safe in inducing clinical remission, promoting mucosal healing, and downregulating Th1/Th17-mediated immune response in short course CD patients with luminal lesions.

Adalimumab Efficacy and Safety by Disease Duration: Analysis of Pooled Studies of Crohn's Disease

2017 ◽  
Vol 152 (5) ◽  
pp. S744
Author(s):  
Remo Panaccione ◽  
Paul Rutgeerts ◽  
William J. Sandborn ◽  
Stefan Schreiber ◽  
Jean Frederic Colombel ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Duration ◽  
Duration Analysis ◽  
Efficacy And Safety

scholarly journals P381 Adalimumab efficacy and safety by disease duration: analysis of pooled studies of Crohn's disease

2017 ◽  
Vol 11 (suppl_1) ◽  
pp. S271-S271
Author(s):  
R. Panaccione ◽  
P. Rutgeerts ◽  
W. Sandborn ◽  
S. Schreiber ◽  
J.-F. Colombel ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Duration ◽  
Duration Analysis ◽  
Efficacy And Safety

Clinical Factors Associated With Response to Fecal Diversion in Crohn’s Disease

2020 ◽  
Vol 86 (10) ◽  
pp. 1277-1280
Author(s):  
Hassan Buhulaigah ◽  
Adam Truong ◽  
Karen Zaghiyan ◽  
Phillip Fleshner
Keyword(s):  
Logistic Regression ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Clinical Response ◽  
Disease Duration ◽  
Binary Logistic Regression ◽  
Fecal Diversion ◽  
Age At Diagnosis ◽  
Perianal Disease ◽  
Perineal Pain

Up to 80% of Crohn’s disease (CD) patients require surgery. Fecal diversion is used selectively in CD proctocolitis refractory to medical treatment or advanced perianal disease. This study examines associations between clinical features in predicting clinical response (CR) to fecal diversion in CD. Charts of CD patients undergoing fecal diversion for medically refractory disease or perianal disease were reviewed. Clinical response was assessed focusing on improvements in urgency, abdominal and perineal pain, decreased anal fistula drainage, and weight gain. Univariate binary logistic regression and multivariate forward-stepwise modeling analysis were used to determine associations with CR. The study cohort comprised 79 patients. After a median follow-up of 36 (3-192) months, 40 (51%) patients achieved a CR. Binary logistic regression analysis revealed both age at diagnosis (hazard ratio [HR] 1.05; confidence interval [CI] 1.01-1.09; P = .007) and disease duration (HR .91; CI .86-.96; P = .001) to be significantly associated with CR. Later age of onset (HR 1.05; CI 1.01-1.10; P = .002) and shorter disease duration (HR .91; CI .86-.97; P = .02) remained significant on multivariate analysis. This largest reported series of fecal diversion for refractory CD in the biologic drug era revealed that young age at diagnosis and long disease duration are associated with a lower CR.

Disease Duration Did Not Influence the Rates of Loss of Efficacy of the Anti-TNF Therapy in Latin American Crohn's Disease Patients

Digestion ◽  
2015 ◽  
Vol 91 (2) ◽  
pp. 158-163 ◽  
Author(s):  
Paulo Gustavo Kotze ◽  
Juliano Coelho Ludvig ◽  
F�bio Vieira Teixeira ◽  
Everson Fernando Malluta ◽  
Eron F�bio Miranda ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Latin American ◽  
Disease Duration

S1136 Increased Risk of Clinical Relapse Is Associated with Longer Disease Duration in Crohn's Disease

2009 ◽  
Vol 136 (5) ◽  
pp. A-197 ◽  
Author(s):  
David T. Rubin ◽  
Arielle G. Bensimon ◽  
Andrew P. Yu ◽  
Eric Wu ◽  
Jingdong Chao ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Duration ◽  
Clinical Relapse ◽  
Increased Risk

scholarly journals The Influence of Microscopic Inflammation at Resection Margins on Early Postoperative Endoscopic Recurrence After Ileocaecal Resection for Crohn’s Disease

2019 ◽  
Vol 14 (3) ◽  
pp. 361-368 ◽  
Author(s):  
Karolina Poredska ◽  
Lumir Kunovsky ◽  
Filip Marek ◽  
Zdenek Kala ◽  
Vladimir Prochazka ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Duration ◽  
Resection Margins ◽  
Endoscopic Recurrence ◽  
Histological Results ◽  
Resected Bowel ◽  
Microscopic Inflammation

Abstract Background and Aims The pathogenesis and risk factors for early postoperative endoscopic recurrence of Crohn’s disease [CD] remain unclear. Thus, this study aimed to identify whether histological inflammation at the resection margins after an ileocaecal resection influences endoscopic recurrence. Methods We have prospectively followed up patients with CD who underwent ileocaecal resection at our hospital between January 2012 and January 2018. The specimens were histologically analysed for inflammation at both of the resection margins [ileal and colonic]. We evaluated whether histological results of the resection margins are correlated with endoscopic recurrence of CD based on colonoscopy 6 months after ileocaecal resection. Second, we assessed the influence of known risk factors and preoperative therapy on endoscopic recurrence of CD. Results A total of 107 patients were included in our study. Six months after ileocaecal resection, 23 patients [21.5%] had an endoscopic recurrence of CD. The histological signs of CD at the resection margins were associated with a higher endoscopic recurrence [56.5% versus 4.8%, p &lt; 0.001]. Disease duration from diagnosis to surgery [p = 0.006] and the length of the resected bowel [p = 0.019] were significantly longer in patients with endoscopic recurrence. Smoking was also proved to be a risk factor for endoscopic recurrence [p = 0.028]. Conclusions Histological inflammation at the resection margins was significantly associated with a higher risk of early postoperative endoscopic recurrence after an ileocaecal resection for CD.

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