scholarly journals Identification of EZH2 and EZH1 Small Molecule Inhibitors with Selective Impact on Diffuse Large B Cell Lymphoma Cell Growth

2013 ◽  
Vol 20 (11) ◽  
pp. 1329-1339 ◽  
Author(s):  
Shivani Garapaty-Rao ◽  
Christopher Nasveschuk ◽  
Alexandre Gagnon ◽  
Eric Y. Chan ◽  
Peter Sandy ◽  
...  
Keyword(s):  
Cell Growth ◽  
B Cell ◽  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Lymphoma Cell ◽  
Large B Cell Lymphoma ◽  
Large B Cell

scholarly journals PMA/IONO affects diffuse large B-cell lymphoma cell growth through upregulation of A20 expression

2016 ◽  
Vol 36 (2) ◽  
pp. 1069-1075 ◽  
Author(s):  
Wenxiu Yang ◽  
Yi Li ◽  
Pinhao Li ◽  
Lingling Wang
Keyword(s):  
Cell Growth ◽  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Lymphoma Cell ◽  
Large B Cell Lymphoma ◽  
Large B Cell

ZLD1122, a novel EZH2 and EZH1 small molecular inhibitor, blocks H3K27 methylation and diffuse large B cell lymphoma cell growth

RSC Advances ◽  
2016 ◽  
Vol 6 (34) ◽  
pp. 28512-28521 ◽  
Author(s):  
Tiantao Gao ◽  
Lidan Zhang ◽  
Yongxia Zhu ◽  
Xuejiao Song ◽  
Qiang Feng ◽  
...  
Keyword(s):  
Cell Growth ◽  
B Cell ◽  
Small Molecule ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Wild Type ◽  
H3k27 Methylation ◽  
Large B Cell Lymphoma ◽  
Molecule Inhibitor ◽  
Large B Cell

Here, we reported a novel, selective, small-molecule inhibitor of EZH2 and EZH1 synthesized by us, ZLD1122, which inhibited both EZH1 and wild type and mutant EZH2 activities with nanomolar potency.

Characterization of the mutational profile of 11 diffuse large B-cell lymphoma cell lines

2017 ◽  
Vol 59 (7) ◽  
pp. 1710-1716 ◽  
Author(s):  
Darius Juskevicius ◽  
Anne Müller ◽  
Hind Hashwah ◽  
Pontus Lundberg ◽  
Alexandar Tzankov ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lines ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Lymphoma Cell ◽  
Large B Cell Lymphoma ◽  
Large B Cell
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