E-waste contains high amount of brominated flame retardants (BFRs) which are toxic, bioaccumulative and recalcitrant. In the present study, an effective and environmental-friendly process using solvothermal treatment to extract tetrabromobisphenol A (TBBPA), a typical BFR from waste computer housing plastic was developed. After the solvothermal process, TBBPA were transferred into a special solvent phase and the bromine content in plastic after solvothermal treatment was greatly reduced, which confirmed the feasibility of solvothermal procedure for TBBPA extraction. This work provides a clean and applicable process for extraction of BFRs from plastic in e-waste.