Mechanistic Crystal Size Distribution (CSD)-based Modelling of Continuous Antisolvent Crystallization of Benzoic Acid

2021 ◽  
Author(s):  
Jaka Orehek ◽  
Matic Češnovar ◽  
Dušan Teslić ◽  
Blaž Likozar
Keyword(s):  
Benzoic Acid ◽  
Size Distribution ◽  
Crystal Size ◽  
Crystal Size Distribution ◽  
Antisolvent Crystallization

Crystal size distribution of benzoic acid at its crystallization from the bulk of vapour phase

1979 ◽  
Vol 44 (7) ◽  
pp. 2165-2172 ◽  
Author(s):  
Jaroslav Vítovec ◽  
Jiří Smolík ◽  
Josef Kugler
Keyword(s):  
Benzoic Acid ◽  
Cooling Rate ◽  
Size Distribution ◽  
Crystal Size ◽  
Vapour Phase ◽  
Crystal Size Distribution ◽  
Water Dispersion ◽  
Small Crystals ◽  
Permeable Walls

Crystal size and their distribution were measured in the crystallizer with gas-permeable walls, at crystallization of benzoic acid vapours from the bulk of vapour phase in the mixture with nitrogen in dependence on concentration (in range from 1.1 to 23 vol.%), temperature (401 to 473 K) and velocity of mixture (0.5 to 6.6 cm/s). At small cooling rate of the mixture the vapours of benzoic acid are condensing in the form of droplets which at continuing cooling solidify. At cooling of the mixture by water dispersion create the needle-shaped crystals. The effect of concentration, temperature and velocity is not profound obviously because by evaporation of water is the mixture rapidly cooled and supersaturated. This results in creation of a large amount of crystal nuclei and thus also of small crystals.

scholarly journals Tunable Protein Crystal Size Distribution via Continuous Slug-Flow Crystallization with Spatially Varying Temperature

CrystEngComm ◽  
2021 ◽  
Author(s):  
Nicholas Mozdzierz ◽  
Moo Sun Hong ◽  
Yongkyu Lee ◽  
Moritz Benisch ◽  
Mo Jiang ◽  
...  
Keyword(s):  
Product Quality ◽  
Size Distribution ◽  
Slug Flow ◽  
Crystal Size ◽  
Quality Attributes ◽  
Crystal Size Distribution ◽  
Protein Crystal ◽  
Manufacturing Cost ◽  
Spatially Varying

Accompanied with the growth of the biopharmaceuticals market has been an interest in developing processes with increased control of product quality attributes at low manufacturing cost, with one of the...

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