Improving crystal size distribution by internal seeding combined cooling/antisolvent crystallization with a cooling/heating cycle

2018 ◽  
Vol 486 ◽  
pp. 130-136 ◽  
Author(s):  
Maheswata Lenka ◽  
Debasis Sarkar
Keyword(s):  
Size Distribution ◽  
Crystal Size ◽  
Crystal Size Distribution ◽  
Heating Cycle ◽  
Antisolvent Crystallization ◽  
Combined Cooling

scholarly journals Tunable Protein Crystal Size Distribution via Continuous Slug-Flow Crystallization with Spatially Varying Temperature

CrystEngComm ◽  
2021 ◽  
Author(s):  
Nicholas Mozdzierz ◽  
Moo Sun Hong ◽  
Yongkyu Lee ◽  
Moritz Benisch ◽  
Mo Jiang ◽  
...  
Keyword(s):  
Product Quality ◽  
Size Distribution ◽  
Slug Flow ◽  
Crystal Size ◽  
Quality Attributes ◽  
Crystal Size Distribution ◽  
Protein Crystal ◽  
Manufacturing Cost ◽  
Spatially Varying

Accompanied with the growth of the biopharmaceuticals market has been an interest in developing processes with increased control of product quality attributes at low manufacturing cost, with one of the...

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