Investigating the effect of operation points on crystal quality in reactive crystallization using continuous flow with high shear stress

2021 ◽  
Vol 176 ◽  
pp. 116-122
Shuntaro Amari ◽  
Chinami Sugawara ◽  
Ryo Harada ◽  
Shoji Kudo ◽  
Hiroshi Takiyama
2018 ◽  
Vol 39 (suppl_1) ◽  
H Spillemaeker ◽  
A Dupont ◽  
A Kauskot ◽  
A Rauch ◽  
F Vincent ◽  

Hypertension ◽  
2005 ◽  
Vol 45 (4) ◽  
pp. 672-680 ◽  
Branko Braam ◽  
Remmert de Roos ◽  
Hans Bluyssen ◽  
Patrick Kemmeren ◽  
Frank Holstege ◽  

Fractals ◽  
1999 ◽  
Vol 07 (01) ◽  
pp. 33-39 ◽  

A model is proposed by which the formation of the vascular network in animals proceeds via progressive penetration of the vessel ramification into a capillary mesh, by means of a laplacian growth mechanism of hydrodynamical origin. In this model, the growth of both arteries and veins follows the directions of high shear stress provoked by the blood flow on the endothelial wall of a pre-existing capillary mesh. This process is shown to be identical to the phenomenon of dendritic growth, which is responsible for the formation of such well-known patterns as dendritic crystals, lightning sparks or branching aggregates of bacteria. A number of straightforward consequences of potentially important medical and physiological interests are deduced. These include the natural and spontaneous organization of the arterial and venal trees, the spontaneous and unavoidable tropism of arteries towards veins and vice-versa, the hierarchical character of the vessels and the possibility of computerized prediction of the vascular pattern from the shape of the capillary bed.

2019 ◽  
Vol 20 (20) ◽  
pp. 5040 ◽  
Thien Ngo ◽  
Keunyoung Kim ◽  
Yiying Bian ◽  
Hakjun Noh ◽  
Kyung-Min Lim ◽  

Antiplatelet agents are important in the pharmacotherapeutic regime for many cardiovascular diseases, including thrombotic disorders. However, bleeding, the most serious adverse effect associated with current antiplatelet therapy, has led to many efforts to discover novel anti-platelet drugs without bleeding issues. Of note, shear stress-induced platelet aggregation (SIPA) is a promising target to overcome bleeding since SIPA happens only in pathological conditions. Accordingly, this study was carried out to discover antiplatelet agents selectively targeting SIPA. By screening various herbal extracts, Paeonia suffruticosa and its major bioactive constituent, paeoniflorin, were identified to have significant inhibitory effects against shear-induced aggregation in human platelets. The effects of paeoniflorin on intraplatelet calcium levels, platelet degranulation, and integrin activation in high shear stress conditions were evaluated by a range of in vitro experiments using human platelets. The inhibitory effect of paeoniflorin was determined to be highly selective against SIPA, through modulating von Willebrand Factor (vWF)-platelet glycoprotein Ib (GP Ib) interaction. The effects of paeoniflorin on platelet functions under high shear stress were confirmed in the ex vivo SIPA models in rats, showing the good accordance with the anti-SIPA effects on human platelets. Treatment with paeoniflorin significantly prevented arterial thrombosis in vivo from the dose of 10 mg/kg without prolonging bleeding time or blood clotting time in rats. Collectively, our results demonstrated that paeoniflorin can be a novel anti-platelet agent selectively targeting SIPA with an improved safety profile.

2016 ◽  
Vol 67 (2) ◽  
pp. 213 ◽  
Toru Kubo ◽  
Hiroaki Kitaoka

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