scholarly journals The Null Hypothesis of IFN-γ and Monocyte Function in Leishmaniasis

2020 ◽  
Vol 27 (5) ◽  
pp. 683-684
Author(s):  
David L. Sacks
Keyword(s):  
Null Hypothesis ◽  
Monocyte Function ◽  
Ifn Γ

scholarly journals G-CSF reduces IFN-γ and IL-4 production by T cells after allogeneic stimulation by indirectly modulating monocyte function

2000 ◽  
Vol 25 (10) ◽  
pp. 1035-1040 ◽  
Author(s):  
Y Nawa ◽  
T Teshima ◽  
K Sunami ◽  
Y Hiramatsu ◽  
Y Maeda ◽  
...  
Keyword(s):  
T Cells ◽  
Monocyte Function ◽  
Ifn Γ ◽  
Allogeneic Stimulation

Electron microscopy analysis of degenerating pancreatic ß cells in transgenic mice expressing the MHC Class I antigen Dd

1990 ◽  
Vol 48 (3) ◽  
pp. 548-549
Author(s):  
T. A. Stewart ◽  
D. Liggitt ◽  
S. Pitts ◽  
L. Martin ◽  
M. Siegel ◽  
...  
Keyword(s):  
Type I Diabetes ◽  
Disease Process ◽  
Class Ii ◽  
Class I ◽  
Type I ◽  
Aberrant Expression ◽  
Mhc Molecules ◽  
Endogenous Insulin ◽  
Class Ii Mhc ◽  
Ifn Γ

Insulin-dependant (Type I) diabetes mellitus (IDDM) is a metabolic disorder resulting from the lack of endogenous insulin secretion. The disease is thought to result from the autoimmune mediated destruction of the insulin producing ß cells within the islets of Langerhans. The disease process is probably triggered by environmental agents, e.g. virus or chemical toxins on a background of genetic susceptibility associated with particular alleles within the major histocompatiblity complex (MHC). The relation between IDDM and the MHC locus has been reinforced by the demonstration of both class I and class II MHC proteins on the surface of ß cells from newly diagnosed patients as well as mounting evidence that IDDM has an autoimmune pathogenesis. In 1984, a series of observations were used to advance a hypothesis, in which it was suggested that aberrant expression of class II MHC molecules, perhaps induced by gamma-interferon (IFN γ) could present self antigens and initiate an autoimmune disease. We have tested some aspects of this model and demonstrated that expression of IFN γ by pancreatic ß cells can initiate an inflammatory destruction of both the islets and pancreas and does lead to IDDM.

IFN-γ induces transcription but not secretion of IL-18 in human colonic epithelial cells

2001 ◽  
Vol 120 (5) ◽  
pp. A704-A704
Author(s):  
S KIESSLING ◽  
K SCHIOTTMANN ◽  
W FALK ◽  
T ANDUS ◽  
J SCHOELMERICH ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Colonic Epithelial Cells ◽  
Ifn Γ

An Alternative to Cohen's κ

2006 ◽  
Vol 11 (1) ◽  
pp. 12-24 ◽  
Author(s):  
Alexander von Eye
Keyword(s):  
Simulation Study ◽  
Null Hypothesis ◽  
Categorical Variables ◽  
Alternative Measure ◽  
Rater Agreement ◽  
Verbal Processing ◽  
Heavy Tailed ◽  
Applicant Selection

At the level of manifest categorical variables, a large number of coefficients and models for the examination of rater agreement has been proposed and used. The most popular of these is Cohen's κ. In this article, a new coefficient, κ s , is proposed as an alternative measure of rater agreement. Both κ and κ s allow researchers to determine whether agreement in groups of two or more raters is significantly beyond chance. Stouffer's z is used to test the null hypothesis that κ s = 0. The coefficient κ s allows one, in addition to evaluating rater agreement in a fashion parallel to κ, to (1) examine subsets of cells in agreement tables, (2) examine cells that indicate disagreement, (3) consider alternative chance models, (4) take covariates into account, and (5) compare independent samples. Results from a simulation study are reported, which suggest that (a) the four measures of rater agreement, Cohen's κ, Brennan and Prediger's κ n , raw agreement, and κ s are sensitive to the same data characteristics when evaluating rater agreement and (b) both the z-statistic for Cohen's κ and Stouffer's z for κ s are unimodally and symmetrically distributed, but slightly heavy-tailed. Examples use data from verbal processing and applicant selection.

Proving the null hypothesis.

1991 ◽  
Vol 46 (10) ◽  
pp. 1089-1089 ◽  
Author(s):  
John J. Bartko
Keyword(s):  
Null Hypothesis
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