Solid-phase micro-extraction–gas chromatography–(tandem) mass spectrometry as a tool for pesticide residue analysis in water samples at high sensitivity and selectivity with confirmation capabilities

2004 ◽  
Vol 1026 (1-2) ◽  
pp. 239-250 ◽  
Author(s):  
C Gonçalves ◽  
M.F Alpendurada
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Solid Phase ◽  
Residue Analysis ◽  
High Sensitivity ◽  
Tandem Mass ◽  
Pesticide Residue Analysis ◽  
Solid Phase Micro Extraction ◽  
Chromatography Tandem Mass Spectrometry ◽  
Sensitivity And Selectivity

scholarly journals Development and validation of an analysis method for pesticide residues by gas chromatography–tandem mass spectrometry in Daikenchuto

2021 ◽  
Author(s):  
Hirokazu Saegusa ◽  
Hiroshi Nomura ◽  
Masaki Takao ◽  
Takashi Hamaguchi ◽  
Masaru Yoshida ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Tandem Mass Spectrometry ◽  
Pesticide Residues ◽  
Residue Analysis ◽  
Herbal Medicines ◽  
Tandem Mass ◽  
Pesticide Residue Analysis ◽  
Analysis Method ◽  
Chromatography Tandem Mass Spectrometry

AbstractDaikenchuto (DKT) is one of the most widely used “Kampo” in Japan as a representative of herbal medicine. Because DKT is made from a natural product like food, it requires the management of pesticides; therefore, an analysis of residual pesticides in Kampo is required. The World Health Organization (WHO) indicates that pesticide residue analysis by the U.S. Pharmacopeia (USP) is required. USP defines 107 compounds containing organochlorine pesticides and organophosphorus pesticides and their metabolites, which have a high residual risk. Accordingly, to guarantee the safety of herbal medicines according to global standards is a very important issue. In this study, we developed an analytical method for 91 compounds, which are listed in USP, using DKT as the subject. The method could extract pesticides from DKT with acetone, elute pesticides with acetonitrile using a SepPak C18 column (5 g) and with ethyl acetate using a DSC-NH2 column (2 g), and perform simultaneous analyses by gas chromatography–tandem mass spectrometry (GC–MS/MS). This method, which could quantify 88 compounds, was validated according to USP. A pesticide residue analysis method that meets USP requirements enables the analysis of pesticide residues with a high residue risk and contributes to improving the safety of “Kampo” and other herbal medicines.

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