Synthesis and characterization of stable polymer-coated C8 stationary phase with high durability under extreme pH conditions for high-performance liquid chromatography

2005 ◽  
Vol 1073 (1-2) ◽  
pp. 163-167 ◽  
Author(s):  
Atsushi Kobayashi ◽  
Kazuko Takezawa ◽  
Hideki Takasaki ◽  
Taketoshi Kanda ◽  
Hiroshi Kutsuna
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Stationary Phase ◽  
High Performance ◽  
Synthesis And Characterization ◽  
High Durability ◽  
Ph Conditions

scholarly journals Isolation, Synthesis and Characterization of Rosiglitazone Maleate Impurities

2008 ◽  
Vol 5 (3) ◽  
pp. 562-566
Author(s):  
Singamsetty Radha Krishna ◽  
Mandava Venkata Naga Brahmeshwar Rao ◽  
Tirmalaraju Satyanaryana Raju ◽  
Vurimidi Himabindu ◽  
Ghanta Mahesh Reddy
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Mass Number ◽  
Synthesis And Characterization ◽  
Reverse Phase ◽  
Bulk Drug

Three unknown impurities in rosiglitazone maleate 1 bulk drug at level below 0.1% (ranging from 0.05 to 0.1%) were detected by simple reverse phase high performance liquid chromatography. These impurities were preliminarily identified with LC-MS and characterized by the mass number of the impurities. Different experiments were conducted and finally synthesized and characterized the unknown impurities.

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