Jokhadze M. ჯოხაძე მ.
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Tushurashvili P. თუშურაშვილი პ.
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Murtazashvili T. მურთაზაშვილი თ.
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Imnadze N. იმნაძე ნ.
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Sivsivadze K. სივსივაძე კ.
In chemichal-toxicological analysis was used the method of Gas Chromatography-Mass Spectrometry. It is considered as one of the most exact method of analysis of chemichal substances. Respectively utilization of this method in determination of widely spread narcotic in biological fluids is important task. As a result of experimental work, was determined optimal conditions of analysis: temperature of injector, fuel and transferline, the thermal gradient, volume of injection, length of the column, thickness of the layer, gass-wearing speed of mobile phase. Detection of Desomorphine was carried by TIC and SIM regime, under the NIST data base. For derivatisation was selected acitilation (acetate anhydride), metilation and sylitation were performed. The optimal sylitation of tetrahydrocanabinol and 11nor-terahydrocanabinol carboxyacide was performed by BSTFA. In the current work is presented the chromatograme and mass-specter of tetrahydrocanabinol and 11-nor-terahydrocanabinol carboxyacide detected in urine.