Risk Factors for Positive Margins in Conservative Surgery for Breast Cancer After Neoadjuvant Chemotherapy

2016 ◽  
Vol 94 (7) ◽  
pp. 379-384
Author(s):  
Alberto Bouzón ◽  
Benigno Acea ◽  
Alejandra García ◽  
Ángela Iglesias ◽  
Joaquín Mosquera ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Neoadjuvant Chemotherapy ◽  
Conservative Surgery ◽  
Positive Margins

scholarly journals Positive margins (R1) risk factors in breast cancer conservative surgery

2019 ◽  
Vol Volume 11 ◽  
pp. 243-248 ◽  
Author(s):  
Augusto Lombardi ◽  
Elena Pastore ◽  
Stefano Maggi ◽  
Gianluca Stanzani ◽  
Valeria Vitale ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Conservative Surgery ◽  
Positive Margins

Risk Factors Associated to Residual Tumor in Re-excision for Positive Margins in Breast Conservative Surgery

2021 ◽  
pp. 000313482110110
Author(s):  
Catherine Sarre-Lazcano ◽  
Uriel Clemente-Gutiérrez ◽  
Francisco U. Pastor-Sifuentes ◽  
Heriberto Medina-Franco
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Local Recurrence ◽  
Residual Tumor ◽  
Conservative Surgery ◽  
Margin Status ◽  
Positive Margins ◽  
Factors Associated ◽  
Breast Conservative Surgery ◽  
Postmenopausal Status

Background Breast conservative surgery (BCS) is an adequate treatment for patients with early breast cancer. Local recurrence is associated with diverse factors. Our objective was to evaluate risk factors associated with finding residual tumor in patients with positive margins in BCS. Methods Observational retrospective study, including patients diagnosed with breast cancer undergoing BCS between 2000 and 2016. Clinicopathological and treatment variables were collected. Main outcome was the finding of residual tumor on re-excision. Positive margins were defined as tumor present on ink. Results Three hundred and six patients underwent BCS. Mean age was 57 ± 12.2 years. Positive margins were found in 84 (27.4%) patients, 15 (4.9%) had unknown margin status, and 207 (67.6%) had negative margins. Seventy-eight patients from the positive margin group and 23 patients from the unknown/negative margin group were reintervened. Residual tumor was present in 41% of patients with positive margins and in 45% of patients with negative margins ( P = .192). In univariate analysis, overweight (P = .04) and positive axillary lymph nodes ( P = .02) were associated with residual tumor on re-excision. In multivariate analysis, postmenopausal status was a protective factor (HR .047, P = .30). Mean follow-up was 58.4 months and mean local recurrence-free survival (LRFS) was 56.4 months (.1-203.2), with no difference regarding margin status or residual tumor. Discussion Postmenopausal status was associated with a decreased rate of residual tumor in patients with positive margins. The presence of residual tumor on re-excision was not associated with a lower LRFS. These factors must be considered when positive margins are present in BCS.

Ultrasound-Guided Breast-Conservative Surgery Decreases the Rate of Reoperations for Palpable Breast Cancer

2018 ◽  
Vol 84 (6) ◽  
pp. 1043-1048
Author(s):  
Salvatore Vieni ◽  
Giuseppa Graceffa ◽  
Roberta Priola ◽  
Martina Fricano ◽  
Stefania Latteri ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Histological Examination ◽  
Standard Technique ◽  
Positive Margin ◽  
Conservative Surgery ◽  
Ultrasound Guided ◽  
Surgical Specimen ◽  
Positive Margins ◽  
Breast Conservative Surgery ◽  
Palpable Breast

The purpose of this study is to verify whether the performance of ultrasound-guided quadrantectomy (USGQ) versus palpation-guided quadrantectomy (PGQ) can reduce the incidence of positive margins and if it can change the attitude of the surgeon. A retrospective study was conducted on 842 patients underwent quadrantectomy for breast cancer, 332 of them underwent USGQ, whereas 550 underwent PGQ. The histological type of the tumors and the margin status obtained with the histological examination were compared. The histological examination of the surgical specimen showed involvement of the margins in 24/842 patients (2.85%), 22 (2.61%) of them belonged to the PGQ group, and two to the USGQ group (P = 0.0011). The highest rate of microscopically positive margins was, statistically significant, for carcinoma in situ, when compared with patients with invasive carcinoma (0.0001). USGQ technique showed several advantages compared with PGQ. In fact, the former notes a lower positive margin rate and, consequently, a lower rate of reintervention. In addition, it may change the surgeon's attitude by causing him to remove another slice of margin to ensure more histological negativity. It should be the gold standard technique for breast-conservative surgery of palpable tumors.

scholarly journals Ways to improve the results of conservative surgery in breast cancer patients

2015 ◽  
Vol 22 (1) ◽  
pp. 28-31
Author(s):  
I. A. Lalak
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Cancer Patients ◽  
Conservative Surgery ◽  
Regional Recurrence ◽  
Breast Cancer Patients

The purpose of this study was to investigate risk factors for locally-regional recurrence of breast cancer after conservative surgery.

scholarly journals Sentinel Node Biopsy After Neoadjuvant Chemotherapy In Breast Cancer: Real Life Results

2021 ◽  
Author(s):  
Marcelo Adeodato Bello ◽  
Anke Bergmann ◽  
Suzana Sales Aguiar ◽  
Marcelo Morais Barbosa ◽  
Emanuelle Narciso Alvarez Valente ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Clinical Stage ◽  
Real Life ◽  
Conservative Surgery ◽  
Lymph Node Biopsy ◽  
Multiple Model ◽  
Advanced Clinical Stage ◽  
Factors Associated ◽  
Node Biopsy

Abstract Purpose: compare demographic, clinical and treatment characteristics of women undergoing neoadjuvant chemotherapy (NAC) for breast cancer (BC) treatment according to the axillary approach and analyze factors associated with the indication of sentinel lymph node biopsy (SLNB) in a real-life scenario. Methods: retrospective cohort study in women diagnosed with BC with indication for NAC. Demographic, clinical, tumor, surgical and adjuvant treatment variables were obtained.. A univariate logistic regression was performed to evaluate the independent factors associated with SLNB indication and a multiple model was applied for adjustments. Results: A total of 918 patients were included in this study, 161 (17.5%) of whom underwent SLNB, 105 (11.4%) who underwent SLNB followed by AL and 652 (71.0%) who underwent AL only. Concerning the adjusted model, women in stage III were 95% less likely to be submitted to an SLNB (OR = 0.05 95% CI 0.01-0.17; p<0.001) compared to those in stage I. Women who underwent mastectomies exhibited a 90% lower chance of undergoing SLNB than those who underwent conservative surgery (95% CI 0.06-0.17; p <0.001). Considering NAC responses, cases with no response or presenting disease progression exhibited a 55% lower chance of undergoing SLNB compared to those displaying a total response (OR = 0.45 95% CI 0.24-0.82; p = 0.009). Conclusion: SLNB was performed in 29% of the patients following NAC. Patients presenting a more advanced clinical stage of the disease with a worse NAC response and those who underwent mastectomies were less likely to undergo SLNB.

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