S.82. Nerve Growth Factor and Its Receptor Promote Growth and Survival of Activated, Effector Memory T Lymphocytes

2009 ◽  
Vol 131 ◽  
pp. S154-S155
Author(s):  
Siba Raychaudhuri ◽  
Smriti K. Raychaudhuri
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
T Lymphocytes ◽  
Effector Memory ◽  
Nerve Growth ◽  
Growth And Survival ◽  
Memory T Lymphocytes

scholarly journals Anti-nerve growth factor Ab abrogates macrophage-mediated HIV-1 infection and depletion of CD4+ T lymphocytes in hu-SCID mice

2003 ◽  
Vol 100 (15) ◽  
pp. 8927-8932 ◽  
Author(s):  
E. Garaci ◽  
S. Aquaro ◽  
C. Lapenta ◽  
A. Amendola ◽  
M. Spada ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
T Lymphocytes ◽  
Scid Mice ◽  
Nerve Growth ◽  
Hiv 1

scholarly journals APPL1 Associates with TrkA and GIPC1 and Is Required for Nerve Growth Factor-Mediated Signal Transduction

2006 ◽  
Vol 26 (23) ◽  
pp. 8928-8941 ◽  
Author(s):  
Dan C. Lin ◽  
Celia Quevedo ◽  
Natalie E. Brewer ◽  
Alex Bell ◽  
Joseph R. Testa ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Sympathetic Neurons ◽  
Pdz Domain ◽  
Neurotrophin Receptor ◽  
Interacting Protein ◽  
Nerve Growth ◽  
Growth And Survival ◽  
Protein Levels ◽  
Extracellular Signal

ABSTRACT The neurotrophin receptor TrkA plays critical roles in the nervous system by recruiting signaling molecules that activate pathways required for the growth and survival of neurons. Here, we report APPL1 as a TrkA-associated protein. APPL1 and TrkA coimmunoprecipitated in sympathetic neurons. We have identified two routes through which this association can occur. APPL1 was isolated as a binding partner for the TrkA-interacting protein GIPC1 from rat brain lysate by mass spectrometry. The PDZ domain of GIPC1 directly engaged the C-terminal sequence of APPL1. This interaction provides a means through which APPL1 may be recruited to TrkA. In addition, the APPL1 PTB domain bound to TrkA, indicating that APPL1 may associate with TrkA independently of GIPC1. Isolation of endosomal fractions by high-resolution centrifugation determined that APPL1, GIPC1, and phosphorylated TrkA are enriched in the same fractions. Reduction of APPL1 or GIPC1 protein levels suppressed nerve growth factor (NGF)-dependent MEK, extracellular signal-regulated kinase, and Akt activation and neurite outgrowth in PC12 cells. Together, these results indicate that GIPC1 and APPL1 play a role in TrkA function and suggest that a population of endosomes bearing a complex of APPL1, GIPC1, and activated TrkA may transmit NGF signals.

scholarly journals The myelin oligodendrocyte glycoprotein directly binds nerve growth factor to modulate central axon circuitry

2015 ◽  
Vol 210 (6) ◽  
pp. 891-898 ◽  
Author(s):  
H.-Christian von Büdingen ◽  
Feng Mei ◽  
Ariele Greenfield ◽  
Sarah Jahn ◽  
Yun-An A. Shen ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Axon Growth ◽  
Myelin Oligodendrocyte Glycoprotein ◽  
Nerve Growth ◽  
Growth And Survival ◽  
Nociceptive Neurons ◽  
Binding Partner ◽  
Pain Pathways ◽  
Exact Function

Myelin oligodendrocyte glycoprotein (MOG) is a central nervous system myelin-specific molecule expressed on the outer lamellae of myelin. To date, the exact function of MOG has remained unknown, with MOG knockout mice displaying normal myelin ultrastructure and no apparent specific phenotype. In this paper, we identify nerve growth factor (NGF) as a binding partner for MOG and demonstrate that this interaction is capable of sequestering NGF from TrkA-expressing neurons to modulate axon growth and survival. Deletion of MOG results in aberrant sprouting of nociceptive neurons in the spinal cord. Binding of NGF to MOG may offer widespread implications into mechanisms that underlie pain pathways.

Screening Natural Products for Effects on Nerve Growth Factor (NGF) Stimulated Neuritogenesis and Neuritic Outgrowth

Planta Medica ◽  
2011 ◽  
Vol 77 (05) ◽  
Author(s):  
ND Chaurasiya ◽  
R Sahu ◽  
V Samoylenko ◽  
M Ilias ◽  
LA Walker ◽  
...  
Keyword(s):  
Natural Products ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Nerve Growth ◽  
Neuritic Outgrowth

Nerve Growth Factor overexpression in Clara cells suppresses metastasis and tumor growth in a mouse model of experimental lung metastasis

Pneumologie ◽  
2012 ◽  
Vol 66 (06) ◽  
Author(s):  
K Seidler ◽  
A Sydykov ◽  
S Müller-Brüsselbach ◽  
R Müller ◽  
N Weißmann ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Mouse Model ◽  
Tumor Growth ◽  
Lung Metastasis ◽  
Clara Cells ◽  
Nerve Growth

Degenerating and Painful Human Intervertebral Discs Release Pronociceptive Factors and Increase Neurite Sprouting and CGRP via Nerve Growth Factor

2014 ◽  
Vol 4 (1_suppl) ◽  
pp. s-0034-1376539-s-0034-1376539
Author(s):  
E. Krock ◽  
D. H. Rosenzweig ◽  
A. J. Chabot-Dore ◽  
P. Jarzem ◽  
M. H. Weber ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Intervertebral Discs ◽  
Nerve Growth
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