Establishment of reference intervals for thyroid function tests during pregnancy

2012 ◽  
Vol 45 (13-14) ◽  
pp. 1114
Author(s):  
K. Mourabit Amari ◽  
L. Bondaz ◽  
J. Girouard ◽  
C. Gagnon ◽  
J. Weisnagel ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Reference Intervals ◽  
Thyroid Function Tests ◽  
Function Tests

Gestation specific reference intervals for thyroid function tests in pregnancy

2016 ◽  
Vol 54 (8) ◽  
Author(s):  
Süleyman Akarsu ◽  
Filiz Akbiyik ◽  
Eda Karaismailoglu ◽  
Zeliha Gunnur Dikmen
Keyword(s):  
Pregnant Women ◽  
Thyroid Function ◽  
First Trimester ◽  
Reference Intervals ◽  
Specific Reference ◽  
Thyroid Function Tests ◽  
Second Trimester ◽  
Third Trimester ◽  
The Third ◽  
Function Tests

AbstractThyroid function tests are frequently assessed during pregnancy to evaluate thyroid dysfunction or to monitor pre-existing thyroid disease. However, using non-pregnant reference intervals can lead to misclassification. International guidelines recommended that institutions should calculate their own pregnancy-specific reference intervals for free thyroxine (FT4), free triiodothyronine (FT3) and thyroid-stimulating hormone (TSH). The objective of this study is to establish gestation-specific reference intervals (GRIs) for thyroid function tests in pregnant Turkish women and to compare these with the age-matched non-pregnant women.Serum samples were collected from 220 non-pregnant women (age: 18–48), and 2460 pregnant women (age: 18–45) with 945 (39%) in the first trimester, 1120 (45%) in the second trimester, and 395 (16%) in the third trimester. TSH, FT4 and FT3 were measured using the Abbott Architect i2000SR analyzer.GRIs of TSH, FT4 and FT3 for first trimester pregnancies were 0.49–2.33 mIU/L, 10.30–18.11 pmol/L and 3.80–5.81 pmol/L, respectively. GRIs for second trimester pregnancies were 0.51–3.44 mIU/L, 10.30–18.15 pmol/L and 3.69–5.90 pmol/L. GRIs for third trimester pregnancies were 0.58–4.31 mIU/L, 10.30–17.89 pmol/L and 3.67–5.81 pmol/L. GRIs for TSH, FT4 and FT3 were different from non-pregnant normal reference intervals.TSH levels showed an increasing trend from the first trimester to the third trimester, whereas both FT4 and FT3 levels were uniform throughout gestation. GRIs may help in the diagnosis and appropriate management of thyroid dysfunction during pregnancy which will prevent both maternal and fetal complications.

Reference Intervals of Thyroid Function Tests in First Trimester Vietnamese Pregnant Women

2020 ◽  
Vol 66 (12/2020) ◽  
Author(s):  
Luong Ly ◽  
Nhu Vuong ◽  
Minh Chau ◽  
Hanh Phan ◽  
Quan Pham ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Thyroid Function ◽  
First Trimester ◽  
Reference Intervals ◽  
Thyroid Function Tests ◽  
Function Tests

Trimester-specific reference intervals of thyroid function tests in Turkish pregnants

2019 ◽  
Vol 36 (5) ◽  
pp. 413-416
Author(s):  
Oktay Bulur ◽  
Zeliha Atak ◽  
Derun Taner Ertugrul ◽  
Esin Beyan ◽  
Emre Gunakan ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Reference Intervals ◽  
Specific Reference ◽  
Thyroid Function Tests ◽  
Function Tests

First- and Second-Trimester Reference Intervals for Thyroid Function Testing in a US Population

2020 ◽  
Author(s):  
Dustin R Bunch ◽  
Kyle Firmender ◽  
Roa Harb ◽  
Joe M El-Khoury
Keyword(s):  
Thyroid Function ◽  
The United States ◽  
Reference Intervals ◽  
Adverse Outcomes ◽  
Specific Reference ◽  
Thyroid Peroxidase ◽  
Thyroid Function Tests ◽  
Second Trimester ◽  
Function Tests ◽  
Increased Risk

Abstract Objectives Thyroid dysfunction in pregnancy is associated with increased risk of adverse outcomes to mother and child. Trimester-specific reference intervals for thyroid function tests are not routinely provided by clinical laboratories. In this study, we present first- and second-trimester-specific reference intervals in a US population for thyroid-stimulating hormone (TSH), free thyroxine (FT4), total thyroxine (T4), and total triiodothyronine (T3) measured on Roche analyzers. Methods We used patient samples from first- and second-trimester prenatal screening. Samples were limited to singleton pregnancies and negative screening results for thyroid peroxidase and thyroglobulin antibodies. Analytes (TSH, FT4, T4, and T3) were measured on a Roche Modular e170 then verified on a Roche cobas e801. Results The reference intervals established on the e170 and verified on the e801 for the first trimester were 0.11 to 3.48 mIU/L for TSH, 11.2 to 19.0 pmol/L for FT4, 51.1 to 185.6 nmol/L for T4, and 1.4 to 3.5 nmol/L for T3. The reference intervals for the second trimester were 0.31 to 3.85 mIU/L for TSH, 9.4 to 16.5 pmol/L for FT4, 55.1 to 174.0 nmol/L for T4, and 1.5 to 3.7 nmol/L for T3. Conclusions This is the first report of trimester-specific reference intervals for thyroid function tests on Roche analyzers in the United States, and it is consistent with worldwide reports.

Reference Intervals of Serum Thyroid Function Tests in a Previously Iodine-Deficient Area

Thyroid ◽  
2005 ◽  
Vol 15 (3) ◽  
pp. 279-285 ◽  
Author(s):  
Henry Völzke ◽  
Dietrich Alte ◽  
Thomas Kohlmann ◽  
Jan Lüdemann ◽  
Matthias Nauck ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Reference Intervals ◽  
Thyroid Function Tests ◽  
Function Tests ◽  
Deficient Area

A Practical Approach for the Verification and Determination of Site- and Trimester-Specific Reference Intervals for Thyroid Function Tests in Pregnancy

Thyroid ◽  
2019 ◽  
Vol 29 (3) ◽  
pp. 412-420 ◽  
Author(s):  
Lois E. Donovan ◽  
Amy Metcalfe ◽  
Alex Chin ◽  
Jennifer M. Yamamoto ◽  
Heidi Virtanen ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Reference Intervals ◽  
Practical Approach ◽  
Specific Reference ◽  
Thyroid Function Tests ◽  
Function Tests ◽  
In Pregnancy
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