Elevated red blood cell distribution width at ICU discharge is associated with readmission to the intensive care unit

2018 ◽  
Vol 55 ◽  
pp. 15-20 ◽  
Author(s):  
Tiago Antonio Tonietto ◽  
Marcio Manozzo Boniatti ◽  
Thiago Costa Lisboa ◽  
Marina Verçoza Viana ◽  
Moreno Calcagnotto dos Santos ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Distribution ◽  
Distribution Width ◽  
Icu Discharge ◽  
Red Blood Cell Distribution

scholarly journals A study on the predictive value of red blood cell distribution width as a biomarker of outcome in paediatric critical illness

2020 ◽  
Vol 7 (12) ◽  
pp. 2347
Author(s):  
Sudha Rudrappa ◽  
Meghana Narasimhegowda ◽  
Girish Gopal
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Blood Cell ◽  
Critically Ill ◽  
Red Blood Cell ◽  
Paediatric Population ◽  
Critically Ill Children ◽  
Cell Distribution ◽  
Distribution Width ◽  
Red Blood Cell Distribution

Background: Red blood cell distribution width (RDW) is a simple, low cost measure, which is routinely reported as a standard component of complete hemogram. Several recent studies have found a positive association between RDW and risk of both morbidity and mortality in several diseases, particularly in critically ill adults.But, data regarding the outcome predictive utility of RDW in critically ill paediatric population is limited. The objective of the study was to determine the association between RDW and mortality and morbidity in paediatric critical illness.Methods: A cross sectional observational study was conducted from February 2019-May 2019 at Cheluvamba Hospital, Mysuru. 97 subjects admitted to Paediatric intensive care unit (PICU) were included in the study. Data regarding subject demographics, hospitalization characteristics, laboratory values and outcomes were collected.Results: A significant positive correlation was found between mortality among critically ill children and RDW measured within 24 hours of PICU admission (p=0.01) and peak RDW during the first 7 days of PICU stay (p=0.01). The relative change in RDW correlated significantly (p=0.01) with the number of intensive care unit (ICU) free days. Our subjects were divided into quartiles based on the admission RDW, subjects in the fourth quartile were found to have the highest mean Paediatric risk of mortality (PRISM III) score, Paediatric index of mortality (PIM 2) score and the least number of ICU free days. Area under the receiver operator curve (AUROC) for incidence of death was 0.706 for admission RDW,0.71 for peak RDW and 0.882 for PIM 2 score.Conclusions: Our data demonstrates that RDW at the time of PICU admission could serve as a cost-effective marker for early identification of critically ill paediatric population who are at risk for adverse outcomes.

scholarly journals Red blood cell distribution width and neutrophil to lymphocyte ratio are associated with outcomes of adult subarachnoid haemorrhage patients admitted to intensive care unit

2017 ◽  
Vol 54 (6) ◽  
pp. 696-701 ◽  
Author(s):  
Yuan-Lan Huang ◽  
Zhi-Jun Han ◽  
Zhi-De Hu
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Blood Cell ◽  
Subarachnoid Haemorrhage ◽  
Regression Model ◽  
Red Blood Cell ◽  
Prognostic Value ◽  
Cell Distribution ◽  
Distribution Width ◽  
Red Blood Cell Distribution

Background Red blood cell distribution width (RDW) and neutrophil to lymphocyte ratio (NLR) have been reported to be associated with outcomes of acute cerebral infarction. However, their prognostic value in patients with subarachnoid haemorrhage (SAH) remains largely unknown. The aim of this study was to investigate the prognostic value of RDW and NLR in SAH patients. Methods Medical records of adult SAH patients admitted to intensive care unit (ICU) were extracted from Multiparameter Intelligent Monitoring in Intensive Care II (MIMIC II, version 2.6), a publicly accessible ICU database. Prognostic value of RDW and NLR was analysed using logistic regression model, Kaplan-Meier curve analysis and Cox regression model. Results A total of 274 SAH patients were included. Patients died in hospital had significantly higher RDW and NLR. RDW and NLR were significantly associated with hospital death, with adjusted odds ratios of 1.39 (95% CI, 1.06–1.82) and 1.04 (95% CI, 1.00–1.08), respectively. Furthermore, increased RDW and NLR were associated with higher one-year mortality, with an adjusted hazard ratio of 1.20 (95% CI, 1.02–1.41) for per 1% increased RDW and 1.03 (95% CI, 1.00–1.05) for per 1 increased NLR. Conclusion RDW and NLR are useful indices to evaluate the outcomes of ICU admitted patients with SAH.

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