Fungal cauda equina lesion with delayed cord compression and treatment response

2018 ◽  
Vol 174 ◽  
pp. 185-186 ◽  
Author(s):  
Barbara M. Decker ◽  
Cindy D. Noyes ◽  
Mary B. Ramundo ◽  
Alissa A. Thomas
Keyword(s):  
Treatment Response ◽  
Cauda Equina ◽  
Cord Compression ◽  
Cauda Equina Lesion

Thoracic spinal cord compression masquerading as cauda equina syndrome

2016 ◽  
Vol 34 (4) ◽  
pp. 756.e3-756.e5 ◽  
Author(s):  
Katherine Stolper ◽  
Erin R. Hanlin ◽  
Michael D. April ◽  
John L. Ritter ◽  
Curtis J. Hunter ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Compression ◽  
Cauda Equina Syndrome ◽  
Cauda Equina ◽  
Cord Compression ◽  
Thoracic Spinal Cord ◽  
Thoracic Spinal

scholarly journals Intradural Spinal Metastasis from Renal Cell Carcinoma: A Case Report

2001 ◽  
Vol 9 (2) ◽  
pp. 57-61 ◽  
Author(s):  
Kan-Hing Mak ◽  
John Ching-Kwong Kwok
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Spinal Metastasis ◽  
Cauda Equina ◽  
History Of ◽  
Epidural Metastasis ◽  
Cauda Equina Lesion ◽  
Osseous Structure ◽  
Intradural Space

Intradural spinal metastasis is rare. This is the third case ever reported on the finding of intradural spinal metastasis from a renal cell carcinoma that had been removed surgically. The patient had a history of epidural metastasis for which excision and anterior stabilization were done 3 years before the new presentation with cauda equina lesion. Seeding from the involved osseous structure to the cerebrospinal fluid through the dura was believed to be the course that tumour had taken to reach the intradural space.

Four cases of spinal cord compression: The need for early diagnosis

1985 ◽  
Vol 71 (2) ◽  
pp. 92-95
Author(s):  
R. K. Bradley ◽  
S. H. Murch
Keyword(s):  
Spinal Cord ◽  
Early Diagnosis ◽  
Clinical Diagnosis ◽  
Spinal Cord Compression ◽  
Cauda Equina ◽  
Cord Compression ◽  
Symptoms And Signs

SummaryFour cases of spinal cord compression, with symptoms and signs evolving over several years or as quickly as two days, are presented. The symptoms and signs of extrinsic cord compression are described and briefly contrasted with those of intrinsic cord or cauda equina lesions. The need for early clinical diagnosis is emphasised.

Dermoid tumors of the spinal cord

1970 ◽  
Vol 33 (6) ◽  
pp. 676-681 ◽  
Author(s):  
Ian C. Bailey
Keyword(s):  
Spinal Cord ◽  
Low Back Pain ◽  
Back Pain ◽  
Cauda Equina ◽  
Complete Removal ◽  
Cord Compression ◽  
Conus Medullaris ◽  
Low Back ◽  
Content Type ◽  
Fine Print

✓ This is an analysis of 10 cases of dermoid tumor occurring in the spinal canal (8 lumbar and 2 thoracic). Low-back pain was the commonest presenting symptom, especially if the tumor was adherent to the conus medullaris. Other complaints included urinary dysfunction and motor and sensory disturbances of the legs. Clinical and radiological evidence of spina bifida was found in about half of the cases and suggested the diagnosis of a developmental type of tumor when patients presented with progressive spinal cord compression. At operation, the tumors were often found embedded in the conus medullaris or firmly adherent to the cauda equina, thus precluding complete removal. Evacuation of the cystic contents, however, gave lasting relief of the low-back pain and did not cause any deterioration in neurological function. In a follow-up study, ranging from 1 to 15 years, virtually no improvement in the neurological signs was observed. On the other hand, only one case has deteriorated due to recurrence of tumor growth.

Radiation-Sensitive Spine Tumor

2018 ◽  
pp. 159-174
Author(s):  
Adam M. Robin ◽  
Ilya Laufer
Keyword(s):  
Spinal Cord ◽  
Multiple Myeloma ◽  
Spinal Cord Compression ◽  
Cauda Equina ◽  
Spinal Metastases ◽  
Cord Compression ◽  
External Beam Radiation ◽  
Spinal Instability ◽  
Mechanical Instability

A decision-making framework called NOMS (neurologic, oncologic, mechanical and systemic) facilitates and guides therapeutic decisions for patients with spinal metastases. Patients should be evaluated for signs of myelopathy or cauda equina syndrome. The Epidural Spinal Cord Compression (ESCC) scale facilitates reporting of the degree of radiographic spinal cord compression. A determination of the expected histology-specific tumor response to conventionally fractionated external beam radiation (cEBRT) and systemic therapy should be made. Radiation therapy effectively treats biologic pain for radiosensitive tumors such as multiple myeloma. Patients should undergo a careful evaluation of movement-associated pain as tumor-induced spinal instability is an independent indication for surgery. Determination of tumor-associated mechanical instability can be facilitated by the Spinal Instability Neoplastic Score (SINS). Herein, the authors present a case of spinal multiple myeloma managed using the NOMS framework and in consideration of current evidence and treatment paradigms.

scholarly journals Transplantation of neural stem cells encapsulated in hydrogels improve functional recovery in a cauda equina lesion model

2020 ◽  
Author(s):  
Zhiyi Fu ◽  
Huidong Wang ◽  
Yujie Wu ◽  
Tong Zhu
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Functional Recovery ◽  
Cauda Equina ◽  
Three Dimensional ◽  
Stem Cell Differentiation ◽  
Blue Staining ◽  
Tail Flick ◽  
Pathological Changes ◽  
Cauda Equina Lesion

Abstract Background This study explored the therapeutic effects of transplantation of neural stem cells (NSCs) encapsulated in hydrogels in a cauda equina lesion model. Methods NSCs were isolated from neonatal dorsal root ganglion (DRG) and cultured in three-dimensional porous hydrogel scaffolds. Immunohistochemistry, transmission electron microscopy, Luxol fast blue staining, TUNEL assay were performed to detect the differentiation capability, ultrastructural and pathological changes, and apoptosis of NSCs. Furthermore, the functional recovery of sensorimotor reflexes was determined using the tail-flick test. Results NSCs derived from DRG were able to proliferate to form neurospheres and mainly differentiate into oligodendrocytes in the three-dimensional hydrogel culture system. After transplantation of NSCs encapsulated in hydrogels, NSCs differentiated into oligodendrocytes, neurons or astrocytes in vivo . Moreover, NSCs engrafted on the hydrogels decreased apoptosis and alleviated the ultrastructural and pathological changes of injured cauda equina. Behavioral analysis showed that transplanted hydrogel-encapsulated NSCs decreased the tail-flick latency and showed a neuroprotective role on injured cauda equina. Conclusions Our results indicate transplantation of hydrogel-encapsulated NSCs promotes stem cell differentiation into oligodendrocytes, neurons or astrocytes and contributes to the functional recovery of injured cauda equina, suggesting that NSCs encapsulated in hydrogels may be applied for the treatment of cauda equina injury.

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