Double-blind, randomized, parallel, placebo-controlled study of ibuprofen effects on thromboxane B2 concentrations in aspirin-tereated healthy adult volunteers

Nonsteroidal anti-inflammatory drugs work by non-selectively inhibiting cyclooxygenase enzymes. Evidence indicates that metabolites of the cyclooxygenase pathway play a critical role in the process of learning and memory. We evaluated whether acute naproxen treatment impairs short-term working memory, episodic memory, or semantic memory in a young, healthy adult population. Participants received a single dose of placebo or naproxen (750 mg) in random order separated by 7–10 days. Two hours following administration, participants completed five memory tasks. The administration of acute high-dose naproxen had no effect on memory in healthy young adults.

Download Full-text

A phase 1, randomized, double‐blind, placebo‐controlled study to evaluate the safety, tolerability, and pharmacokinetics of single and multiple doses of lisdexamfetamine dimesylate in Japanese and Caucasian healthy adult subjects

Neuropsychopharmacology Reports ◽

10.1002/npr2.12082 ◽

2019 ◽

Vol 40 (1) ◽

pp. 16-29 ◽

Cited By ~ 1

Author(s):

James Ermer ◽

Patrick Martin ◽

Mary Corcoran ◽

Yumiko Matsuo

Keyword(s):

Healthy Adult ◽

Phase 1 ◽

Controlled Study ◽

Lisdexamfetamine Dimesylate ◽

Double Blind ◽

Double Blind Placebo ◽

Single And Multiple Doses ◽

Multiple Doses

Download Full-text

The Effect of 2 Injection Speeds on Local Anesthetic Discomfort During Inferior Alveolar Nerve Blocks

Anesthesia Progress ◽

10.2344/11-00037.1 ◽

2015 ◽

Vol 62 (3) ◽

pp. 106-109 ◽

Cited By ~ 4

Author(s):

Marcelo Rodrigo de Souza Melo ◽

Mark Jon Santana Sabey ◽

Carla Juliane Lima ◽

Liane Maciel de Almeida Souza ◽

Francisco Carlos Groppo

Keyword(s):

Pain Perception ◽

Crossover Trial ◽

Healthy Adult ◽

Inferior Alveolar Nerve ◽

Needle Insertion ◽

Test Results ◽

Nerve Blocks ◽

Double Blind ◽

Significant Difference ◽

Adult Volunteers

Abstract This randomized double-blind crossover trial investigated the discomfort associated with 2 injection speeds, low (60 seconds) and slow (100 seconds), during inferior alveolar nerve block by using 1.8 mL of 2% lidocaine with 1 : 100,000 epinephrine. Three phases were considered: (a) mucosa perforation, (b) needle insertion, and (c) solution injection. Thirty-two healthy adult volunteers needing bilateral inferior alveolar nerve blocks at least 1 week apart were enrolled in the present study. The anesthetic procedure discomfort was recorded by volunteers on a 10-cm visual analog scale in each phase for both injection speeds. Comparison between the 2 anesthesia speeds in each phase was performed by paired t test. Results showed no statistically significant difference between injection speeds regarding perforation (P = .1016), needle placement (P = .0584), or speed injection (P = .1806). The discomfort in all phases was considered low. We concluded that the 2 injection speeds tested did not affect the volunteers' pain perception during inferior alveolar nerve blocks.

Download Full-text