Analysis of acute naproxen administration on memory in young adults: A randomized, double-blind, placebo-controlled study
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Nonsteroidal anti-inflammatory drugs work by non-selectively inhibiting cyclooxygenase enzymes. Evidence indicates that metabolites of the cyclooxygenase pathway play a critical role in the process of learning and memory. We evaluated whether acute naproxen treatment impairs short-term working memory, episodic memory, or semantic memory in a young, healthy adult population. Participants received a single dose of placebo or naproxen (750 mg) in random order separated by 7–10 days. Two hours following administration, participants completed five memory tasks. The administration of acute high-dose naproxen had no effect on memory in healthy young adults.
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2008 ◽
Vol 53
(8)
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pp. 2059-2065
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2012 ◽
Vol 130
(4)
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pp. 886-893.e5
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2014 ◽
Vol 73
(Suppl 2)
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pp. 1090.3-1090
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