Genetic Mutation Screen in Early Non–Small-Cell Lung Cancer (NSCLC) Specimens

2014 ◽  
Vol 15 (2) ◽  
pp. 159-165 ◽  
Author(s):  
Jair Bar ◽  
Maya Damianovich ◽  
Goni Hout Siloni ◽  
Erel Dar ◽  
Yoram Cohen ◽  
...  
Cancers ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 4705
Author(s):  
Olga Rodak ◽  
Manuel David Peris-Díaz ◽  
Mateusz Olbromski ◽  
Marzenna Podhorska-Okołów ◽  
Piotr Dzięgiel

Non-small cell lung cancer (NSCLC) is a subtype of the most frequently diagnosed cancer in the world. Its epidemiology depends not only on tobacco exposition but also air quality. While the global trends in NSCLC incidence have started to decline, we can observe region-dependent differences related to the education and the economic level of the patients. Due to an increasing understanding of NSCLC biology, new diagnostic and therapeutic strategies have been developed, such as the reorganization of histopathological classification or tumor genotyping. Precision medicine is focused on the recognition of a genetic mutation in lung cancer cells called “driver mutation” to provide a variety of specific inhibitors of improperly functioning proteins. A rapidly growing group of approved drugs for targeted therapy in NSCLC currently allows the following mutated proteins to be treated: EGFR family (ERBB-1, ERBB-2), ALK, ROS1, MET, RET, NTRK, and RAF. Nevertheless, one of the most frequent NSCLC molecular sub-types remains without successful treatment: the K-Ras protein. In this review, we discuss the current NSCLC landscape treatment focusing on targeted therapy and immunotherapy, including first- and second-line monotherapies, immune checkpoint inhibitors with chemotherapy treatment, and approved predictive biomarkers.


2017 ◽  
Vol 6 (5) ◽  
pp. 976-980 ◽  
Author(s):  
Shoufeng Wang ◽  
Naiquan Mao ◽  
Chuantian Zuo ◽  
Hong Pan ◽  
Tong Xie ◽  
...  

2016 ◽  
Vol 22 ◽  
pp. 176
Author(s):  
Genevieve Streb ◽  
Narjust Duma ◽  
Natasha Piracha ◽  
Sejal Kothadia ◽  
Komal Patel ◽  
...  

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