Emotional Problems, Quality of Life, and Symptom Burden in Patients With Lung Cancer

e16570 Background: The main objective of our study was to assess patient reported symptom burden and impact on quality of life in advanced non small cell lung cancer (NSCLC) patients in the United States. Methods: Patients with advanced (stage IIIB/IV) NSCLC (N=450) were recruited with informed consent in a nationwide (US) lung cancer study from Oct-Dec 2011. Patient reported symptoms were assessed using the Lung Cancer Symptom Scale (LCSS) on a 0-100 visual analogue scale and included six symptoms: fatigue, appetite loss, shortness of breath, cough, pain and blood in sputum. An average symptom burden index was calculated. Quality of life was assessed using the Functional Assessment of Cancer Therapy- Lung (FACT-L).Higher scores indicate higher symptom severity on the LCSS and better quality of life on the FACT-L. Correlation between the total FACT-L score and LCSS symptom burden index was assessed. A multivariate regression analysis was performed with FACT-L total score as the dependent variable and LCSS symptom scores as predictors controlling for age, gender, stage and performance status. Results: Majority of the patients were male (59%), Caucasian (74%), smokers/ex-smokers (78%) with an average age of 64 years. Proportion of patients reporting each lung cancer symptom was: Fatigue (100%), loss of appetite (97%), shortness of breath (95%), cough (93%), pain (92%) and blood in sputum (63%). The average (SD) symptom burden index was 42.3 (21.5).The mean± SD severity scores on symptoms were: fatigue (53.2±24.7), loss of appetite (48.1±25.8), cough (48.4±29.9), shortness of breath (44.7± 27), pain (39.7± 28.1) and blood in sputum (18.4±23.6). The average (SD) FACT-L score was 71.7 (25.3). A significant negative correlation was found between the LCSS symptom burden index and FACT-L scores (ρ= -0.82; p<0.001). Loss of appetite (β=-0.204; p<0.001), cough (β= -0.145; p<0.01), pain (β=-0.265; p<0.001), shortness of breath (β = -0.145; p<0.01), age (β= 0.217; p<0.05) and performance status (β = 0.283; p<0.001) were found to be significant predictors of quality of life. Conclusions: Cough, pain, shortness of breath and loss of appetite contribute to symptom burden and have a significant negative impact on quality of life in advanced NSCLC patients.

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P3.15-17 Lung Cancer Symptom Burden and Quality of Life: Findings from the Cancer Experience Registry

Journal of Thoracic Oncology ◽

10.1016/j.jtho.2018.08.1893 ◽

2018 ◽

Vol 13 (10) ◽

pp. S997 ◽

Cited By ~ 1

Author(s):

A. Zaleta ◽

M. Miller ◽

S. Mcmanus ◽

J. Olson ◽

L. House ◽

...

Keyword(s):

Quality Of Life ◽

Lung Cancer ◽

Symptom Burden ◽

Cancer Experience

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Longitudinal Changes in Function, Symptom Burden, and Quality of Life in Patients with Early-Stage Lung Cancer

Annals of Surgical Oncology ◽

10.1245/s10434-012-2741-4 ◽

2012 ◽

Vol 20 (6) ◽

pp. 1788-1797 ◽

Cited By ~ 18

Author(s):

Marianna Koczywas ◽

Anna Cathy Williams ◽

Mihaela Cristea ◽

Karen Reckamp ◽

Frederic W. Grannis ◽

...

Keyword(s):

Quality Of Life ◽

Lung Cancer ◽

Early Stage ◽

Symptom Burden ◽

Early Stage Lung Cancer ◽

Longitudinal Changes ◽

Stage Lung Cancer

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Feasibility, acceptability, and efficacy of online supportive care for individuals living with and beyond lung cancer: a systematic review

Supportive Care in Cancer ◽

10.1007/s00520-021-06274-x ◽

2021 ◽

Author(s):

Jordan Curry ◽

Michael Patterson ◽

Sarah Greenley ◽

Mark Pearson ◽

Cynthia C. Forbes

Keyword(s):

Quality Of Life ◽

Lung Cancer ◽

Supportive Care ◽

Emotional Functioning ◽

Symptom Burden ◽

Feasibility Studies ◽

Symptom Distress ◽

Care Needs ◽

Cancer Data

Abstract Purpose To examine the evidence of the feasibility, acceptability, and potential efficacy of online supportive care interventions for people living with and beyond lung cancer (LWBLC). Methods Studies were identified through searches of Medline, EMBASE, PsychINFO, and CINAHL databases using a structured search strategy. The inclusion criteria (1) examined the feasibility, acceptability, and/or efficacy of an online intervention aiming to provide supportive care for people living with and beyond lung cancer; (2) delivered an intervention in a single arm or RCT study pre/post design; (3) if a mixed sample, presented independent lung cancer data. Results Eight studies were included; two randomised controlled trials (RCTs). Included studies reported on the following outcomes: feasibility and acceptability of an online, supportive care intervention, and/or changes in quality of life, emotional functioning, physical functioning, and/or symptom distress. Conclusion Preliminary evidence suggests that online supportive care among individuals LWBLC is feasible and acceptable, although there is little high-level evidence. Most were small pilot and feasibility studies, suggesting that online supportive care in this group is in its infancy. The integration of online supportive care into the cancer pathway may improve quality of life, physical and emotional functioning, and reduce symptom distress. Online modalities of supportive care can increase reach and accessibility of supportive care platforms, which could provide tailored support. People LWBLC display high symptom burden and unmet supportive care needs. More research is needed to address the dearth of literature in online supportive care for people LWBLC.

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Relationship between cytokine gene single nucleotide polymorphisms and symptom burden and quality of life in lung cancer survivors

Cancer ◽

10.1002/cncr.25255 ◽

2010 ◽

Vol 116 (17) ◽

pp. 4103-4113 ◽

Cited By ~ 47

Author(s):

Sarah M. Rausch ◽

Matthew M. Clark ◽

Christi Patten ◽

Heshan Liu ◽

Sara Felten ◽

...

Keyword(s):

Quality Of Life ◽

Lung Cancer ◽

Single Nucleotide Polymorphisms ◽

Cancer Survivors ◽

Symptom Burden ◽

Nucleotide Polymorphisms ◽

Cytokine Gene ◽

Single Nucleotide

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Lung Cancer

Psycho-Oncology ◽

10.1093/med/9780190097653.003.0023 ◽

2021 ◽

pp. 162-168

Author(s):

Marianne Davies

Keyword(s):

Quality Of Life ◽

Lung Cancer ◽

Psychological Distress ◽

Cancer Patients ◽

Late Stage ◽

Symptom Burden ◽

Lung Cancer Patients ◽

Stage Disease ◽

Late Stage Disease

Lung cancer is the leading cause of cancer-related deaths worldwide. Most patients are diagnosed with late-stage disease. Ninety percent of lung cancer cases can be attributed to tobacco smoking. Smoking cessation efforts have led to reductions in cancer-related deaths. Early screening can help to diagnose patients at earlier stages with improved outcomes. Lung cancer patients suffer the highest symptom burden and psychological distress above other cancers. Symptom burden is due to late-stage disease and treatment side effects. Psychological distress, anxiety, and depression are influenced by internal and external stigma. These lead to the negative impact on quality of life for lung cancer patients as well as family caregivers. Lung cancer–specific tools have been developed to assist in the screening and identification of distress, stigma, and quality-of-life metrics for lung cancer patients. Several organizations have formed to support the educational and psychological needs of lung cancer patients. Early assessment of symptom and psychological distress and integration of palliative care services can improve the quality of life of patients with lung cancer.

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Quality of Life and Symptom Burden among Long-Term Lung Cancer Survivors

Journal of Thoracic Oncology ◽

10.1097/jto.0b013e3182397b3e ◽

2012 ◽

Vol 7 (1) ◽

pp. 64-70 ◽

Cited By ~ 78

Author(s):

Ping Yang ◽

Andrea L. Cheville ◽

Jason A. Wampfler ◽

Yolanda I. Garces ◽

Aminah Jatoi ◽

...

Keyword(s):

Quality Of Life ◽

Lung Cancer ◽

Cancer Survivors ◽

Symptom Burden

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Symptom burden and quality of life in advanced non-small cell lung cancer patients in France and Germany

Lung Cancer ◽

10.1016/j.lungcan.2013.03.008 ◽

2013 ◽

Vol 81 (2) ◽

pp. 288-293 ◽

Cited By ~ 75

Author(s):

Shrividya Iyer ◽

Gavin Taylor-Stokes ◽

Adam Roughley

Keyword(s):

Quality Of Life ◽

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cancer Patients ◽

Cell Lung Cancer ◽

Symptom Burden ◽

Small Cell ◽

Small Cell Lung ◽

Lung Cancer Patients

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Feasibility of a multimodal exercise, nutrition, and palliative care intervention in advanced lung cancer

BMC Cancer ◽

10.1186/s12885-021-07872-y ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Manuel Ester ◽

S. Nicole Culos-Reed ◽

Amane Abdul-Razzak ◽

Julia T. Daun ◽

Delaney Duchek ◽

...

Keyword(s):

Quality Of Life ◽

Physical Activity ◽

Lung Cancer ◽

Symptom Management ◽

Symptom Burden ◽

Advanced Lung Cancer ◽

Post Intervention ◽

Management Intervention ◽

Exercise Classes

Abstract Background Advanced lung cancer patients face significant physical and psychological burden leading to reduced physical function and quality of life. Separately, physical activity, nutrition, and palliative symptom management interventions have been shown to improve functioning in this population, however no study has combined all three in a multimodal intervention. Therefore, we assessed the feasibility of a multimodal physical activity, nutrition, and palliative symptom management intervention in advanced lung cancer. Methods Participants received an individually tailored 12-week intervention featuring in-person group-based exercise classes, at-home physical activity prescription, behaviour change education, and nutrition and palliative care consultations. Patients reported symptom burden, energy, and fatigue before and after each class. At baseline and post-intervention, symptom burden, quality of life, fatigue, physical activity, dietary intake, and physical function were assessed. Post-intervention interviews examined participant perspectives. Results The multimodal program was feasible, with 44% (10/23) recruitment, 75% (75/100) class attendance, 89% (8/9) nutrition and palliative consult attendance, and 85% (17/20) assessment completion. Of ten participants, 70% (7/10) completed the post-intervention follow-up. Participants perceived the intervention as feasible and valuable. Physical activity, symptom burden, and quality of life were maintained, while tiredness decreased significantly. Exercise classes prompted acute clinically meaningful reductions in fatigue, tiredness, depression, pain, and increases in energy and well-being. Conclusion A multimodal physical activity, nutrition, and palliative symptom management intervention is feasible and shows potential benefits on quality of life that warrant further investigation in a larger cohort trial. Trial registration NCT04575831, Registered 05 October 2020 – Retrospectively registered.

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