Incidence of metabolic bone disease in preterm infants of birth weight <1250 g and in those suffering from bronchopulmonary dysplasia

2018 ◽  
Vol 23 ◽  
pp. 234-239 ◽  
Author(s):  
Paola Gaio ◽  
Giovanna Verlato ◽  
Marco Daverio ◽  
Maria Elena Cavicchiolo ◽  
Daniel Nardo ◽  
...  
Keyword(s):  
Birth Weight ◽  
Preterm Infants ◽  
Bronchopulmonary Dysplasia ◽  
Bone Disease ◽  
Metabolic Bone Disease ◽  
Metabolic Bone

scholarly journals Comparison of prevalence and characteristics of fractures in term and preterm infants in the first 3 years of life

2020 ◽  
Author(s):  
Liting Tong ◽  
Sarita Pooranawattanakul ◽  
Jaya Sujatha Gopal-Kothandapani ◽  
Amaka C. Offiah
Keyword(s):  
Emergency Department ◽  
Birth Weight ◽  
Linear Regression ◽  
Low Birth Weight ◽  
Preterm Infants ◽  
Bone Disease ◽  
Metabolic Bone Disease ◽  
Categorical Variables ◽  
Metabolic Bone ◽  
Significant Difference

Abstract Background Preterm infants may be more vulnerable to fractures due to various factors, including metabolic bone disease, but an increased risk of fractures up to the age of 2 is unproven. Objective To compare fracture patterns in premature and full-term children in the first 3 years of life. Materials and methods A retrospective study was conducted. We excluded any child who returned with the same injury, with known metabolic bone disease, with any disease or condition known to reduce bone density, who received any medication known to affect Vitamin D metabolism within 3 months of enrollment or who had fractures post-surgery/resuscitation. Variables such as the number of fractures sustained each year, age of presentation to the Emergency Department and mechanism of injury were compared between the preterm and term groups using statistical analysis (χ2 and Fisher exact test for categorical variables and Student’s t-test for continuous variables). Simple linear regression was performed on the total number of fractures sustained by age 3. Results Forty-four children with fractures were included. Of these, none were born extremely preterm, 24 (55%) were preterm, and 20 (45%) were born at term. Mean gestational ages of the preterm and term groups were 32 weeks 3 days and 39 weeks 6 days, respectively. There were no extremely low birth weight or very low birth weight children. There was no significant difference in the number of fractures sustained yearly, the age of presentation to the Emergency Department or the site of fracture between preterm and term groups. Linear regression showed that the total number of fractures sustained by age 3 years was unrelated to prematurity status, gender or birth weight category. Conclusion No significant difference in fracture number or pattern was identified.

scholarly journals Postnatal Changes in Humerus Cortical Bone Thickness Reflect the Development of Metabolic Bone Disease in Preterm Infants

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Shuko Tokuriki ◽  
Aiko Igarashi ◽  
Takashi Okuno ◽  
Genrei Ohta ◽  
Takuya Kosaka ◽  
...  
Keyword(s):  
Risk Factors ◽  
Mechanical Ventilation ◽  
Birth Weight ◽  
Cortical Bone ◽  
Preterm Infants ◽  
Gestational Age ◽  
Bone Disease ◽  
Metabolic Bone Disease ◽  
Bone Thickness ◽  
Metabolic Bone

Objective. To use cortical bone thickness (CBT) of the humerus to identify risk factors for the development of metabolic bone disease in preterm infants.Methods. Twenty-seven infants born at <32 weeks of gestational age, with a birth weight of <1,500 g, were enrolled. Humeral CBT was measured from chest radiographs at birth and at 27-28, 31-32, and 36–44 weeks of postmenstrual age (PMA). The risk factors for the development of osteomalacia were statistically analyzed.Results. The humeral CBT at 36–44 weeks of PMA was positively correlated with gestational age and birth weight and negatively correlated with the duration of mechanical ventilation. CBT increased with PMA, except in six very early preterm infants in whom it decreased. Based on logistic regression analysis, gestational age and duration of mechanical ventilation were identified as risk factors for cortical bone thinning.Conclusions. Humeral CBT may serve as a radiologic marker of metabolic bone disease at 36–44 weeks of PMA in preterm infants. Cortical bones of extremely preterm infants are fragile, even when age is corrected for term, and require extreme care to lower the risk of fractures.

scholarly journals Metabolic bone disease in preterm infants.

1985 ◽  
Vol 60 (7) ◽  
pp. 682-685 ◽  
Author(s):  
O G Brooke ◽  
A Lucas
Keyword(s):  
Preterm Infants ◽  
Bone Disease ◽  
Metabolic Bone Disease ◽  
Metabolic Bone

scholarly journals Preventive use of Calcitriol versus cholecalciferol on biochemical markers of Metabolic Bone Disease (MBD) in very low birth weight infants: a pilot randomized clinical trial

2021 ◽  
Author(s):  
Mohammad bagher Hosseini ◽  
Nafiseh Hosseini ◽  
Taher Entezari-Maleki ◽  
Zakieh Salimi
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Preterm Infants ◽  
Biochemical Markers ◽  
Metabolic Bone Disease ◽  
Very Low Birth Weight ◽  
Low Birth Weight Infants ◽  
Hydroxyvitamin D ◽  
Metabolic Bone ◽  
25 Hydroxyvitamin D

About 55% of extremely-low-birth-weight (birth weight < 1000 g) and 23% of very-low-birth-weight infants (birth weight < 1500 g) suffer from metabolic bone disease (MBD). There are limited data on the use of calcitriol (1, 25-dihydroxycholecalciferol) to prevent or treat MBD in preterm infants. Therefore, this study aimed to compare the preventive effect of calcitriol and cholecalciferol on the biochemical markers of MBD in preterm infants. This study was a pilot randomized controlled trial conducted in the Alzahra teaching hospital of Tabriz University of Medical Sciences. we randomized 72 very-low-birth-weight infants in two groups of calcitriol 0.25 µg/day and cholecalciferol 400 IU/day. Biochemical markers, including serum 25-hydroxyvitamin D, Alkaline phosphatase (ALP), Phosphorus (P), calcium (Ca), Parathyroid hormone (PTH), and tubular reabsorption of phosphate (TRP) levels were checked at baseline, three, and five weeks after medication, consecutively. After three weeks of supplementation, infants in the cholecalciferol group had higher levels of serum 25-hydroxyvitamin D (P=0.001) and lower levels of urine phosphate (P=0.009); There were no significant differences in other biochemical markers. At the end of the fifth week, there was no significant difference between the two groups in terms of biochemical markers. Conclusion: The study indicated that the use of cholecalciferol caused a lower urinary loss of phosphate in very-low-birth-weight infants at a short time; however, these findings were not sustained during the study period.

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