scholarly journals Risk of congenital toxoplasmosis in women with low or indeterminate anti-Toxoplasma IgG avidity index in the first trimester of pregnancy: an observational retrospective study

2019 ◽  
Vol 25 (6) ◽  
pp. 761.e9-761.e13 ◽  
Author(s):  
L.R. Tomasoni ◽  
G. Messina ◽  
F. Genco ◽  
L. Scudeller ◽  
M. Prestia ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Congenital Toxoplasmosis ◽  
First Trimester ◽  
Avidity Index ◽  
Igg Avidity ◽  
First Trimester Of Pregnancy

scholarly journals The development of the Sabin–Pinkerton triad despite prenatal screening for congenital toxoplasmosis

2021 ◽  
Vol 17 (3) ◽  
pp. 270-274
Author(s):  
Urszula Dryja ◽  
◽  
Anna Niwald ◽  
Ewa Majda-Stanisławska ◽  
◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Prenatal Screening ◽  
Congenital Toxoplasmosis ◽  
Congenital Infection ◽  
First Trimester ◽  
Imaging Findings ◽  
Pregnant Mother ◽  
First Trimester Of Pregnancy ◽  
Toxoplasma Gondii Infection ◽  
Antiparasitic Treatment

The paper presents a case of a boy who developed the symptoms of congenital toxoplasmosis: hydrocephalus, retinitis, choroiditis and intracranial calcifications (the Sabin–Pinkerton triad). Despite prenatal screening in the first trimester of pregnancy (in accordance with the guidelines of the Ministry of Health), which indicated the diagnosis of asymptomatic primary Toxoplasma gondii infection in the pregnant mother, no antiparasitic therapy was used. The presented serological and imaging findings, as well as specialist consultations confirm the intensified effects of congenital infection in the child. Although the child was put on anti-toxoplasma therapy immediately after birth, he developed severe psychophysical development disorders. The paper discusses recommendations for maternal diagnosis and antiparasitic treatment that could have prevented the full-blown congenital toxoplasmosis in the described patient.

DISTURBANCE OF ANDROSTENEDIOL CONVERTING IN PLACENTA DURING REACTIVATION OF CYTOMEGALOVIRUS INFECTION IN THE FIRST TRIMESTER OF PREGNANCY

2016 ◽  
Vol 1 (61) ◽  
pp. 80-83
Author(s):  
Андриевская ◽  
Irina Andrievskaya ◽  
Шолохов ◽  
Leonid Sholokhov
Keyword(s):  
Cytomegalovirus Infection ◽  
Medical Abortion ◽  
First Trimester ◽  
Igg Antibodies ◽  
Reaction Products ◽  
Avidity Index ◽  
Cytomegalovirus Reactivation ◽  
Hardware Complex ◽  
Enzyme Method ◽  
First Trimester Of Pregnancy

The aim is to analyze androstenediol converting in villous chorions at gestation against cytomegalovirus infection activation during the first trimester of pregnancy. 48 villous chorions samples taken during medical abortion at 8-10th weeks of gestation of women with chronic cytomegalovirus reactivation during pregnancy became the material for study, and 35 villous chorions samples were taken as the control. The results of pregnant women examination were analyzed from the point of cytomegalovirus infection activity with immune-enzyme method by the presence of IgM antibodies or by the value of 4-times and more growth of IgG antibodies titer in paired sera in dynamics in 10 days. IgG avidity index to cytomegalovirus was more than 75% in all women. Androstenediol converting was assessed with histochemical methods. Quantitative evaluation of the reaction products was carried out on sections under the microscope MT (Japan) associated with software-hardware complex «SCION Corporation» (USA). Histochemical reaction product of the androstenediol dehydrogenase was well detected in cyto- and syncytiotrophoblast of chorious villi. Reaction activity in the material from women with reactivation of cytomegalovirus infection during pregnancy was low, which indicated a reduction in the reserve for the synthesis of estrogen. The concentration of estriol and estradiol in villous chorions during reactivation of cytomegalovirus infection decreased till 24.9±2.01 nmol/l and 15765.1±107.77 pmol/l, respectively.

Sign in / Sign up

Export Citation Format

Share Document