Hemoglobin levels during the first trimester of pregnancy are associated with the risk of gestational diabetes mellitus, pre-eclampsia and preterm birth in Chinese women: a retrospective study

Objective: The aim of this study is to evaluate the relationship between hematological changes in early pregnancy using complete blood count parameters and gestational diabetes mellitus. Study Design: One hundred pregnant with gestational diabetes mellitus and one hundred healthy pregnant were included in the study. Blood samples for routine complete blood count parameters in first trimester of pregnancy were analyzed. Results: In the gestational diabetes mellitus group white blood cell, platelet count, neutrophil and lymphocyte count, mean platelet volume, red cell distribution width were significantly higher than control group. However, there was no significant difference between groups with regard to neutrophil to lymphocyte ratio and platelet to lymphocyte ratio levels. In binary logistic regression analysis; first trimester mean platelet volume and red cell distribution width values were found to be independently associated with diagnosis of gestational diabetes mellitus. Conclusion: This study demonstrates that hematological parameters in first trimester of pregnancy are closely associated with gestational diabetes mellitus. The parameters that are routinely and automatically calculated in complete blood count; may be used to predict gestational diabetes mellitus.

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Criteria for Screening and Diagnosis of Gestational Diabetes Mellitus in the First Trimester of Pregnancy

Fetal Diagnosis and Therapy ◽

10.1159/000324684 ◽

2011 ◽

Vol 30 (2) ◽

pp. 108-115 ◽

Cited By ~ 19

Author(s):

Walter Plasencia ◽

Raquel Garcia ◽

Susana Pereira ◽

Ranjit Akolekar ◽

Kypros H. Nicolaides

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

First Trimester ◽

First Trimester Of Pregnancy ◽

Screening And Diagnosis

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Lower Adiponectin Levels at First Trimester of Pregnancy Are Associated With Increased Insulin Resistance and Higher Risk of Developing Gestational Diabetes Mellitus

Diabetes Care ◽

10.2337/dc12-1731 ◽

2013 ◽

Vol 36 (6) ◽

pp. 1577-1583 ◽

Cited By ~ 67

Author(s):

M. Lacroix ◽

M.-C. Battista ◽

M. Doyon ◽

J. Menard ◽

J.-L. Ardilouze ◽

...

Keyword(s):

Diabetes Mellitus ◽

Insulin Resistance ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

First Trimester ◽

First Trimester Of Pregnancy

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The association of first trimester high blood pressure and risk of gestational diabetes mellitus

Arterial’naya Gipertenziya (Arterial Hypertension) ◽

10.18705/1607-419x-2012-18-1-67-72 ◽

2012 ◽

Vol 18 (1) ◽

pp. 67-72

Author(s):

P. V. Popova ◽

A. S. Gerasimov ◽

E. N. Kravchuk ◽

E. S. Shelepova ◽

E. M. Ryazantseva ◽

...

Keyword(s):

Diabetes Mellitus ◽

Blood Pressure ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Fold Increase ◽

First Trimester ◽

Elevated Blood Pressure ◽

Elevated Blood ◽

Increased Risk ◽

First Trimester Of Pregnancy

Objective. To determine the relationship between blood pressure measured during the first trimester of pregnancy and the risk of the development of gestational diabetes mellitus. Design and methods. A total of 209 pregnant women were screened for gestational diabetes mellitus between weeks 24 and 28 of gestation, as defined by WHO criteria. Blood pressure, weight and waist circumference data were obtained by review of the medical records. Results. An elevated blood pressure at first trimester of pregnancy was associated with a six-fold increase in the risk of the development of gestational diabetes mellitus (OR = 5.8, 95 % CI 1.9-17.5, p = 0.001) compared with non-hypertensive women. Arterial hypertension (including controlled forms) in the first trimester of pregnancy was followed by a three-fold (OR = 3.04, 95 % CI 1.5-6.3) increase in the risk of gestational diabetes mellitus compared with non-hypertensive women (p = 0.005). Conclusion. Obtained data indicate that women with elevated blood pressure in the first trimester of pregnancy have an increased risk of the development of gestational diabetes mellitus.

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Performance and the Optimal Cut-Off Value of First-Trimester Fasting Plasma Glucose To Identify Gestational Diabetes Mellitus: A Retrospective Study From Southern China

10.21203/rs.3.rs-1067857/v1 ◽

2021 ◽

Author(s):

Jia-Ning Tong ◽

Lin-Lin Wu ◽

Yi-Xuan Chen ◽

Xiao-Nian Guan ◽

Kan Liu ◽

...

Keyword(s):

Diabetes Mellitus ◽

Retrospective Study ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Pregnant Women ◽

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Maternal Age ◽

First Trimester ◽

Fasting Plasma

Abstract Purpose Previous studies have suggested that first-trimester fasting plasma glucose (FPG) is associated with gestational diabetes mellitus (GDM) and is a predictor of GDM. The aim of the present study was to explore whether first-trimester FPG levels can be used as a screening and diagnostic test for GDM in pregnant women. Methods This retrospective study included pregnant women who had their first-trimester FPG recorded at 9-13+6 weeks and underwent screening for GDM using the 2-hour 75 g oral glucose tolerance test (OGTT) between 24th and 28th gestational weeks. The cut-off values were calculated using a receiver operating characteristic (ROC) curve. Results The medical records of 28,030 pregnant women were analysed, and 4,669 (16.66%) of them were diagnosed with GDM. The mean first-trimester FPG was 4.62 ± 0.37 mmol/L. The total trend in the optimal cut-off value of first-trimester FPG in pregnant women was 4.735 mmol/L, with a sensitivity of 49%, a specificity of 67.6% and AUC of 0.608 (95% CI: 0.598-0.617, p༜0.001). Moreover, as the maternal age increased, the optimal cut-off values increased, respectively. The results suggest that first-trimester FPG can be considered a marker for identifying pregnant women with GDM. Conclusion The level of first-trimester FPG increased slightly with maternal age and, as maternal age increased, the optimal cut-off values increased, especially after age 30. The first-trimester FPG should be considered a screening marker when diagnosing GDM in pregnant women.

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