An experimental study on RBC count and serum potassium concentration changes during compression transfusion of WBC-removal whole blood

AbstractSeveral factors that can lead to falsely elevated values of serum. Thrombocytosis is one of these factors, since breakage or activation of platelets during blood coagulation in vitro may lead to spurious release of potassium. The purpose of the study was to evaluate to which extent the platelet count may impact on potassium in both serum and plasma.The study population consisted of 42 subjects with platelets values comprised between 20 and 750×10Significant differences were found between potassium values in serum and in plasma. A significant correlation was also observed between serum potassium values and the platelet count in whole blood, but not with the age, sex, erythrocyte and leukocyte counts in whole blood. No similar correlation was noticed between plasma potassium and platelet count in whole blood. The frequency of hyperkalemia was also found to be higher in serum (20%) than in plasma (7%) in samples with a platelet count in whole blood >450×10The results of this study show that platelets in the biological samples may impact on potassium measurement when exceeding 450×10

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Correcting hypokalaemia in a paediatric patient with Bartter syndrome through oral dose of potassium chloride intravenous solution

SAGE Open Medical Case Reports ◽

10.1177/2050313x211019789 ◽

2021 ◽

Vol 9 ◽

pp. 2050313X2110197

Author(s):

Salman Alasfour ◽

Haya S Alfailakawi ◽

Yousif A Shamsaldeen

Keyword(s):

Paediatric Patient ◽

Potassium Chloride ◽

Serum Potassium ◽

Nasogastric Tube ◽

Potassium Concentration ◽

Oral Route ◽

Bartter Syndrome ◽

Intravenous Route ◽

Serum Potassium Concentration ◽

Main Challenge

Bartter syndrome is a rare autosomal recessive disorder characterized by hypokalaemia. Hypokalaemia is defined as low serum potassium concentration ˂3.5 mmol/L, which may lead to arrhythmia and death if left untreated. The aim of this case report was to normalize serum potassium concentration without the need for intravenous intervention. A 5-month-old male of 2.7 kg body weight diagnosed with Bartter syndrome was admitted to the general paediatric ward with acute severe hypokalaemia and urinary tract infection. The main challenge was the inability to administer drugs through intravenous route due to compromised body size. Therefore, we shifted the route of administration to the nasogastric tube/oral route. A total of 2 mL of concentrated intravenous potassium chloride (4 mEq potassium) were dissolved in distilled water and administered through nasogastric tube. Serum potassium concentration was rapidly normalized, which culminated in patient discharge. In conclusion, shifting drug administration from intravenous to oral route in a paediatric patient with Bartter syndrome includes numerous advantages such as patient convenience, minimized risk of cannula-induced infection, and reduced nurse workload.

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THE EFFECT IN HUMANS OF EXTRACELLULAR pH CHANGE ON THE RELATIONSHIP BETWEEN SERUM POTASSIUM CONCENTRATION AND INTRACELLULAR POTASSIUM 1

Journal of Clinical Investigation ◽

10.1172/jci103352 ◽

1956 ◽

Vol 35 (9) ◽

pp. 935-939 ◽

Cited By ~ 192

Author(s):

James M. Burnell ◽

Mario F. Villamil ◽

Ben T. Uyeno ◽

Belding H. Scribner

Keyword(s):

Serum Potassium ◽

Potassium Concentration ◽

Extracellular Ph ◽

Ph Change ◽

Serum Potassium Concentration ◽

Intracellular Potassium ◽

The Relationship

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Influence of beta2-adrenoceptor stimulation and blockade on cardiac electrophysiologic properties and serum potassium concentration in the anesthetized dog

American Heart Journal ◽

10.1016/0002-8703(87)90913-6 ◽

1987 ◽

Vol 113 (5) ◽

pp. 1066-1070 ◽

Cited By ~ 13

Author(s):

Stefan H Hohnloser ◽

Richard L Verrier ◽

Bernard Lown

Keyword(s):

Serum Potassium ◽

Potassium Concentration ◽

Serum Potassium Concentration

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SERUM POTASSIUM CONCENTRATION AS A GUIDE TO POTASSIUM NEED

Journal of the American Medical Association ◽

10.1001/jama.1957.02980090013004 ◽

1957 ◽

Vol 164 (9) ◽

pp. 959 ◽

Cited By ~ 32

Author(s):

James M. Burnell

Keyword(s):

Serum Potassium ◽

Potassium Concentration ◽

Serum Potassium Concentration

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Serum Potassium Concentration and Use of Ouabain in Experimental Tourniquet Shock

American Journal of Physiology-Legacy Content ◽

10.1152/ajplegacy.1957.189.3.605 ◽

1957 ◽

Vol 189 (3) ◽

pp. 605-608 ◽

Cited By ~ 1

Author(s):

W. F. Rosse ◽

A. L. Bennett ◽

A. R. McIntyre

Keyword(s):

Blood Pressure ◽

Serum Potassium ◽

Potassium Level ◽

Serum Potassium Level ◽

Potassium Concentration ◽

Mean Blood Pressure ◽

Serum Potassium Concentration ◽

Average Value ◽

Tourniquet Shock ◽

The Mean

Shock was induced in dogs by the release of tourniquets which had been applied to the hind legs for 5 hours. The serum potassium level was followed by spaced sampling. It was seen to rise slightly (from an average of 4.02 mEq/l. to an average of 4.66 mEq/l.) during the prerelease period. Five minutes after the release of the tourniquets, the level had risen to an average of 7.50 mEq/l. and thirty minutes after the release, it had risen to an average of 8.56 mEq/l. At the critical point in the progress of the syndrome (when the mean blood pressure was approximately 50 mm Hg) the average value was 8.46 mEq/l. Ouabain was administered and the level of serum potassium was seen to rise, attaining values as high as 14.67 mEq/l. in one case. The results and significance of these increased levels are briefly discussed as well as an animadversion upon the effects of ouabain on the mean blood pressure.

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PARALYSIS DUE TO REDUCED SERUM POTASSIUM CONCENTRATION DURING TREATMENT OF DIABETIC ACIDOSIS: REPORT OF CASE TREATED WITH 33 GRAMS OF POTASSIUM CHLORIDE INTRAVENOUSLY

Annals of Internal Medicine ◽

10.7326/0003-4819-30-6-1272 ◽

1949 ◽

Vol 30 (6) ◽

pp. 1272 ◽

Cited By ~ 15

Keyword(s):

Potassium Chloride ◽

Serum Potassium ◽

Potassium Concentration ◽

Serum Potassium Concentration

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Acid-Activated Renin Responses to Hydrochlorothiazide, Propranolol and Indomethacin

Clinical Science ◽

10.1042/cs055151s ◽

1978 ◽

Vol 55 (s4) ◽

pp. 151s-153s ◽

Cited By ~ 1

Author(s):

J. K. McKenzie ◽

E. Reisin

Keyword(s):

Blood Pressure ◽

Serum Potassium ◽

Potassium Concentration ◽

Hypertensive Patients ◽

Serum Potassium Concentration ◽

Active Renin ◽

Serum Aldosterone ◽

Low Salt ◽

Inactive Renin ◽

Marked Suppression

1. Six essential hypertensive patients (five with low renin) were treated in successive weeks with placebo; hydrochlorothiazide 100 mg (382 μmol)/day; hydrochlorothiazide and 50 mmol of sodium/day diet; hydrochlorothiazide, 50 mmol of sodium diet and propranolol 160 mg (544 μmol)/day; and hydrochlorothiazide, 50 mmol of sodium and indomethacin 100 mg (287 μmol)/day. 2. Although blood pressure remained unchanged and serum potassium fell on diuretic with or without low salt, there was a marked increase of active renin and a lesser increase of inactive renin, resulting in an increased proportion of active to total renin. 3. Propranolol decreased both active and inactive renin, but not significantly. 4. Indomethacin produced a marked suppression of active renin, a smaller reduction in inactive renin, and a reduction of the ratio of active to total renin almost to placebo values. 5. Blood pressure rose to control values on indomethacin despite the fall in renin whereas it fell with propranolol with little change in renin. 6. Serum aldosterone rose with stimulation but remained elevated despite effective renin suppression with indomethacin and continuing reduced serum potassium concentration.

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