Synthesis of monodisperse maghemite nanoparticles by the microemulsion method

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF cytokine superfamily. TRAIL is able to induce apoptosis through engagement of its death receptors DR4 and DR5 in a wide variety of tumor cells while sparing vital normal cells. This makes it a promising agent for cancer therapy. Here, we present two different ways of covalently grafting TRAIL onto maghemite nanoparticles (NPs): (a) by using carboxylic acid groups of the protein to graft it onto maghemite NPs previously functionalized with amino groups, and (b) by using the amino functions of the protein to graft it onto NPs functionalized with carboxylic acid groups. The two resulting nanovectors, NH-TRAIL@NPs-CO and CO-TRAIL@NPs-NH, were thoroughly characterized. Biological studies performed on human breast and lung carcinoma cells (MDA-MB-231 and H1703 cell lines) established these nanovectors are potential agents for cancer therapy. The pro-apoptotic effect is somewhat greater for CO-TRAIL@NPs-NH than NH-TRAIL@NPs-CO, as evidenced by viability studies and apoptosis analysis. A computational study indicated that regardless of whether TRAIL is attached to NPs through an acid or an amino group, DR4 recognition is not affected in either case.

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Synthesis and characterization of surfactant assisted hydroxyapatite powder using microemulsion method

Materials Today Proceedings ◽

10.1016/j.matpr.2021.05.059 ◽

2021 ◽

Author(s):

V. Collins Arun Prakash ◽

I. Venda ◽

V. Thamizharasi

Keyword(s):

Synthesis And Characterization ◽

Microemulsion Method ◽

Hydroxyapatite Powder ◽

Surfactant Assisted

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Catalytic Combustion of Methane over Perovskite Supported on Lanthanum Hexaaluminate Prepared Through the Microemulsion Method

Science and Technology in Catalysis 2006 - Studies in Surface Science and Catalysis ◽

10.1016/b978-0-444-53202-2.50105-6 ◽

2007 ◽

pp. 465-468

Author(s):

Erik Elm Svensson ◽

Matteo Lualdi ◽

Magali Boutonnet ◽

Sven G. Järås

Keyword(s):

Catalytic Combustion ◽

Microemulsion Method ◽

Catalytic Combustion Of Methane ◽

Lanthanum Hexaaluminate

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Heterogeneity of population of microorganisms grown in presence of iron oxide maghemite nanoparticles

EPJ Web of Conferences ◽

10.1051/epjconf/201818510002 ◽

2018 ◽

Vol 185 ◽

pp. 10002 ◽

Cited By ~ 2

Author(s):

Tatyana P. Denisova ◽

Elena V. Simonova ◽

Lubov A. Kokorina ◽

Evgenia N. Maximova ◽

Oleg M. Samatov ◽

...

Keyword(s):

Iron Oxide ◽

Intercellular Communication ◽

Maghemite Nanoparticles ◽

Cultivation Temperature ◽

Large White ◽

Laser Target ◽

Water Based

In this work γ-Fe2O3 MNPs were obtained by laser target evaporation and water based suspensions were prepared. Maximum permissive dose of iron in water (MPD) is 0.3 mg/L. It was found that 100 MPD dose of iron induces formation of non-typical colonies after 72 or 96 hours exposition: against a background of small black colonies large white colonies appeared due to a disruption in tyrosine synthesis. Multiple re-cloning of the white colonies grown with MNPs showed that they retained their properties both under standard conditions (temperature of 24 °C) and at the temperatures up to 37o C. E.nigrum grown with MNPs demonstrated very scant extension of small colonies at the cultivation temperature of 24o C, their growth was completely blocked at 37°C. Significant changes in the structure of the population were noted. First of all, large cells with pronounced aggregation were observed among the black colonies. These aggregates consisted of large cells connected to each other by matrix. In the white colonies the appearance of very long threadlike cells connecting different groups of the cells establishing an intercellular communication was evident. Fe2O3 MNPs induce an increase in the heterogeneity of the population, expressed as a change in morpho-physiological states.

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