Poly(methyl methacrylate) (core)–biosurfactant (shell) nanoparticles: Size controlled sub-100nm synthesis, characterization, antibacterial activity, cytotoxicity and sustained drug release behavior

Author(s):  
Chinmay Hazra ◽  
Debasree Kundu ◽  
Aniruddha Chatterjee ◽  
Ambalal Chaudhari ◽  
Satyendra Mishra
2018 ◽  
Vol 6 (7) ◽  
pp. 1035-1043 ◽  
Author(s):  
Jian He ◽  
Lisha Ai ◽  
Xin Liu ◽  
Hao Huang ◽  
Yuebin Li ◽  
...  

The NIR-laser-driven plasmonic photothermal and sustained drug release behavior of CuS–PTX/SiO2 nanocapsules show great synergistic chemo-photothermal therapeutic effects on cancer cells in vitro and in vivo.


2018 ◽  
Vol 12 (6) ◽  
pp. 822-826
Author(s):  
Lei Jiang ◽  
Chen Su ◽  
Zhongjie Zhu ◽  
Yanyi Wen ◽  
Shan Ye ◽  
...  

Pharmaceutics ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 1717
Author(s):  
Lei Xu ◽  
Qingliang Yang ◽  
Wei Qiang ◽  
Huijie Li ◽  
Weizhen Zhong ◽  
...  

Three-dimensional (3D) printing technology, specifically stereolithography (SLA) technology, has recently created exciting possibilities for the design and fabrication of sophisticated dosages for oral administration, paving a practical way to precisely manufacture customized pharmaceutical dosages with both personalized properties and sustained drug release behavior. However, the sustained drug release achieved in prior studies largely relies on the presence of hydrophilic excipients in the printing formulation, which unfortunately impedes the printability and formability of the corresponding printing formulations. The current study developed and prepared mini-sized oral pellets using the SLA technique and successfully accomplished a hydrophilic excipient-independent drug release behavior. With ibuprofen as the model drug, the customized photopolymerizable printing formulation included polyethylene glycol diacrylate (PEGDA) as a monomer and diphenyl (2,4,6-trimethylbenzoyl) phosphine oxide (TPO) as a photoinitiator. The produced mini-sized pellets were thoroughly investigated for various factors, including their printability, physical properties, microscopic features, drug content, and drug-release profiles. The drug release profiles from the printed pellets that were larger size (3 mm and 6 mm) followed the Ritger–Peppas model, demonstrating that the release was influenced by both the diffusion of the dissolved drug and by the erosion of the hydrophilic excipients (PEG400). The profiles from the smaller printed pellets (1 mm and 2 mm) followed first release kinetics, not only illustrating that the release was impacted only by drug diffusion, but also indicating that there is a size boundary between the dependent and independent hydrophilic excipients. These results could create practical benefits to the pharmaceutical industry in terms of the design and development personalized dosages using the SLA printing technique with controllable drug release by manipulating size alone.


RSC Advances ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 6287-6298 ◽  
Author(s):  
Yuanfeng Wei ◽  
Jianjun Zhang ◽  
Yazhen Zheng ◽  
Yaxiang Gong ◽  
Meng Fu ◽  
...  

Cubosomes with surface cross-linked chitosan exhibit anti-digestion effect, sustained drug release behavior, and significantly enhanced oral bioavailability of vinpocetine.


2014 ◽  
Vol 2 (3) ◽  
pp. 1 ◽  
Author(s):  
Hassan Nageh ◽  
Metwally Ezzat ◽  
Mohammed Ghanim ◽  
Ahmed Hassanin ◽  
Ahmed Abd El-Moneim

2010 ◽  
Vol 81 (2) ◽  
pp. 213-218 ◽  
Author(s):  
Junjun Tan ◽  
Yanxiang Li ◽  
Ruigang Liu ◽  
Hongliang Kang ◽  
Deqian Wang ◽  
...  

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