Dry powder aerosols of curcumin-chitosan nanoparticle complex prepared by spray freeze drying and their antimicrobial efficacy against common respiratory bacterial pathogens

2016 ◽  
Vol 504 ◽  
pp. 34-42 ◽  
Author(s):  
Hong Yu ◽  
The-Thien Tran ◽  
Jeanette Teo ◽  
Kunn Hadinoto
Keyword(s):  
Freeze Drying ◽  
Bacterial Pathogens ◽  
Antimicrobial Efficacy ◽  
Dry Powder ◽  
Dry Powder Aerosols ◽  
Chitosan Nanoparticle ◽  
Spray Freeze Drying ◽  
Powder Aerosols ◽  
Nanoparticle Complex

scholarly journals Intratracheal inoculation of AHc vaccine induces protection against aerosolized botulinum neurotoxin A challenge in mice

npj Vaccines ◽  
2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Changjiao Gan ◽  
Wenbo Luo ◽  
Yunzhou Yu ◽  
Zhouguang Jiao ◽  
Sha Li ◽  
...  
Keyword(s):  
Bronchoalveolar Lavage ◽  
Clostridium Botulinum ◽  
Freeze Drying ◽  
Botulinum Neurotoxin ◽  
Secretory Iga ◽  
Immune Protection ◽  
Dry Powder ◽  
Botulinum Neurotoxin A ◽  
Spray Freeze Drying

AbstractBotulinum neurotoxin (BoNT), produced by Clostridium botulinum, is generally known to be the most poisonous of all biological toxins. In this study, we evaluate the protection conferred by intratracheal (i.t.) inoculation immunization with recombinant Hc subunit (AHc) vaccines against aerosolized BoNT/A intoxication. Three AHc vaccine formulations, i.e., conventional liquid, dry powder produced by spray freeze drying, and AHc dry powder reconstituted in water are prepared, and mice are immunized via i.t. inoculation or subcutaneous (s.c.) injection. Compared with s.c.-AHc-immunized mice, i.t.-AHc-immunized mice exhibit a slightly stronger protection against a challenge with 30,000× LD50 aerosolized BoNT/A. Of note, only i.t.-AHc induces a significantly higher level of toxin-neutralizing mucosal secretory IgA (SIgA) production in the bronchoalveolar lavage of mice. In conclusion, our study demonstrates that the immune protection conferred by the three formulations of AHc is comparable, while i.t. immunization of AHc is superior to s.c. immunization against aerosolized BoNT/A intoxication.

Dry powder aerosols of polyethylenimine (PEI)-based gene vectors mediate efficient gene delivery to the lung

2011 ◽  
Vol 154 (1) ◽  
pp. 69-76 ◽  
Author(s):  
Corinna Pfeifer ◽  
Guenther Hasenpusch ◽  
Senta Uezguen ◽  
Manish Kumar Aneja ◽  
Dietrich Reinhardt ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Dry Powder ◽  
Dry Powder Aerosols ◽  
Efficient Gene ◽  
Gene Vectors ◽  
Powder Aerosols

Effect of Relative Humidity on Bipolar Electrostatic Charge Profiles of dry Powder Aerosols

2017 ◽  
Vol 34 (8) ◽  
pp. 1707-1715 ◽  
Author(s):  
Jiaqi Yu ◽  
Jennifer Wong ◽  
Ari Ukkonen ◽  
Jonna Kannosto ◽  
Hak-Kim Chan
Keyword(s):  
Relative Humidity ◽  
Electrostatic Charge ◽  
Dry Powder ◽  
Dry Powder Aerosols ◽  
Powder Aerosols
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