Magnetite nanocluster@poly(dopamine)-PEG@ indocyanine green nanobead with magnetic field-targeting enhanced MR imaging and photothermal therapy in vivo

2016 ◽  
Vol 141 ◽  
pp. 467-475 ◽  
Author(s):  
Ming Wu ◽  
Qingtang Wang ◽  
Da Zhang ◽  
Naishun Liao ◽  
Lingjie Wu ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Mr Imaging ◽  
Indocyanine Green ◽  
Photothermal Therapy

Coordination polymer hybridized Au nanocages: a nanoplatform for dual-modality imaging guided near-infrared driven photothermal therapy in vivo

2017 ◽  
Vol 5 (44) ◽  
pp. 8761-8769 ◽  
Author(s):  
Congyang Yan ◽  
Lili Cui ◽  
Qi Yang ◽  
Xiaobao Zhou ◽  
Lixing Pan ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Coordination Polymer ◽  
Mr Imaging ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Dual Modality ◽  
Dual Modality Imaging

Coordination polymer hybridized Au nanocages (AuNC@CPs) were prepared, which were used for near-infrared (NIR)-driven photothermal therapy (PTT) guided by photoacoustic (PA) and magnetic resonance (MR) imaging in vivo.

A zeolitic imidazolate framework-8-based indocyanine green theranostic agent for infrared fluorescence imaging and photothermal therapy

2018 ◽  
Vol 6 (23) ◽  
pp. 3914-3921 ◽  
Author(s):  
Tianzheng Wang ◽  
Siqi Li ◽  
Zhen Zou ◽  
Luo Hai ◽  
Xue Yang ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Fluorescence Imaging ◽  
Photothermal Therapy ◽  
Zeolitic Imidazolate Framework ◽  
Theranostic Agent

A zeolitic imidazolate framework-8-based indocyanine green theranostic agent was constructed for fluorescence imaging and photothermal therapy of tumors in vivo.

scholarly journals Accounting for biological aggregation in heating and imaging of magnetic nanoparticles

TECHNOLOGY ◽  
2014 ◽  
Vol 02 (03) ◽  
pp. 214-228 ◽  
Author(s):  
Michael L. Etheridge ◽  
Katie R. Hurley ◽  
Jinjin Zhang ◽  
Seongho Jeon ◽  
Hattie L. Ring ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Mr Imaging ◽  
Fractal Dimensions ◽  
Imaging Method ◽  
Aggregate Morphology ◽  
Fetal Bovine ◽  
Aqueous Conditions ◽  
Imaging Performance ◽  
Phosphate Buffered Saline

Aggregation is a known consequence of nanoparticle use in biology and medicine; however, nanoparticle characterization is typically performed under the pretext of well-dispersed, aqueous conditions. Here, we systematically characterize the effects of aggregation on the alternating magnetic field induced heating and magnetic resonance (MR) imaging performance of iron oxide nanoparticles (IONPs) in non-ideal biological systems. Specifically, the behavior of IONP aggregates composed of ~ 10 nm primary particles, but with aggregate hydrodynamic sizes ranging from 50 nm to 700 nm, was characterized in phosphate buffered saline and fetal bovine serum suspensions, as well as in gels and cells. We demonstrate up to a 50% reduction in heating, linked to the extent of aggregation. To quantify aggregate morphology, we used a combination of hydrodynamic radii distribution, intrinsic viscosity, and electron microscopy measurements to describe the aggregates as quasifractal entities with fractal dimensions in the 1.8–2.0 range. Importantly, we are able to correlate the observed decrease in magnetic field induced heating with a corresponding decrease in longitudinal relaxation rate (R1) in MR imaging, irrespective of the extent of aggregation. Finally, we show in vivo proof-of-principle use of this powerful new imaging method, providing a critical tool for predicting heating in clinical cancer hyperthermia.

scholarly journals In vitro and in vivo MRI imaging and photothermal therapeutic properties of Hematite (α-Fe2O3) Nanorods

2022 ◽  
Vol 33 (1) ◽  
Author(s):  
Aanisa Gulzar ◽  
Nowsheena Ayoub ◽  
Jaffar Farooq Mir ◽  
Amer M. Alanazi ◽  
M. A. Shah ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Photothermal Therapy ◽  
Imaging Techniques ◽  
Mri Imaging ◽  
Mri Contrast ◽  
Therapy Effect ◽  
Therapeutic Properties ◽  
Prepared Nanorods

AbstractHerein we report synthesis of hematite (α-Fe2O3) nanorods by calcinating hydrothermally synthesized goethite nanorods at 5000C. The structural, optical and MRI imaging guided cancer therapeutic properties of fabricated nanorods have been discussed in this manscript. FESEM and TEM imaging techniques were used to confirm the nanorod like morphology of as prepared materials. As we know that Fe2O3 nanorods with size in the range of 25–30 nm exhibit super magnetism. After coating with the PEG, the as prepared nanorods can be used as T2 MR imaging contrast agents. An excellent T2 MRI contrast of 38.763 mM–1s–1 achieved which is highest reported so far for α-Fe2O3. Besides the as prepared nanorods display an excellent photothermal conversion efficiency of 39.5% thus acts as an excellent photothermal therapeutic agent. Thus, we envision the idea of testing our nanorods for photothermal therapy and MR imaging application both in vitro and in vivo, achieving an excellent T2 MRI contrast and photothermal therapy effect with as prepared PEGylated nanorods.

scholarly journals Liposomes for PET and MR Imaging and for Dual Targeting (Magnetic Field/Glucose Moiety): Synthesis, Properties, and in Vivo Studies

2017 ◽  
Vol 14 (2) ◽  
pp. 406-414 ◽  
Author(s):  
Jérémy Malinge ◽  
Bastien Géraudie ◽  
Paul Savel ◽  
Valérie Nataf ◽  
Aurélie Prignon ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Mr Imaging ◽  
In Vivo Studies ◽  
Dual Targeting ◽  
Synthesis Properties

Chitosan coated gold nanorod chelating gadolinium for MRI-visible photothermal therapy of cancer

RSC Advances ◽  
2016 ◽  
Vol 6 (112) ◽  
pp. 111337-111344 ◽  
Author(s):  
Chunyang Zhang ◽  
Fang Zhang ◽  
Wei Wang ◽  
Jie Liu ◽  
Ming Xu ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Photothermal Therapy ◽  
Gold Nanorod ◽  
Multifunctional Nanoparticles

The multifunctional nanoparticles synthesized via nonsolvent counterion complexation method are applied for in vivo MR imaging and photothermal therapy of cancer.

Spectroscopic imaging of human disease

1996 ◽  
Vol 54 ◽  
pp. 884-885
Author(s):  
D.J. Meyerhoff
Keyword(s):  
Magnetic Field ◽  
Magnetic Resonance ◽  
Field Gradient ◽  
Human Disease ◽  
Morphological Changes ◽  
Magnetic Field Gradient ◽  
Spectroscopic Imaging ◽  
Resonance Spectroscopy ◽  
Tissue Water

Magnetic Resonance Imaging (MRI) observes tissue water in the presence of a magnetic field gradient to study morphological changes such as tissue volume loss and signal hyperintensities in human disease. These changes are mostly non-specific and do not appear to be correlated with the range of severity of a certain disease. In contrast, Magnetic Resonance Spectroscopy (MRS), which measures many different chemicals and tissue metabolites in the millimolar concentration range in the absence of a magnetic field gradient, has been shown to reveal characteristic metabolite patterns which are often correlated with the severity of a disease. In-vivo MRS studies are performed on widely available MRI scanners without any “sample preparation” or invasive procedures and are therefore widely used in clinical research. Hydrogen (H) MRS and MR Spectroscopic Imaging (MRSI, conceptionally a combination of MRI and MRS) measure N-acetylaspartate (a putative marker of neurons), creatine-containing metabolites (involved in energy processes in the cell), choline-containing metabolites (involved in membrane metabolism and, possibly, inflammatory processes),

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