A zeolitic imidazolate framework-8-based indocyanine green theranostic agent for infrared fluorescence imaging and photothermal therapy

2018 ◽  
Vol 6 (23) ◽  
pp. 3914-3921 ◽  
Author(s):  
Tianzheng Wang ◽  
Siqi Li ◽  
Zhen Zou ◽  
Luo Hai ◽  
Xue Yang ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Fluorescence Imaging ◽  
Photothermal Therapy ◽  
Zeolitic Imidazolate Framework ◽  
Theranostic Agent

A zeolitic imidazolate framework-8-based indocyanine green theranostic agent was constructed for fluorescence imaging and photothermal therapy of tumors in vivo.

Gold Nanorod−Photosensitizer Complex for Near-Infrared Fluorescence Imaging and Photodynamic/Photothermal Therapy In Vivo

ACS Nano ◽  
2011 ◽  
Vol 5 (2) ◽  
pp. 1086-1094 ◽  
Author(s):  
Boseung Jang ◽  
Jin-Young Park ◽  
Ching-Hsuan Tung ◽  
In-Hoo Kim ◽  
Yongdoo Choi
Keyword(s):  
Fluorescence Imaging ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Gold Nanorod ◽  
Near Infrared Fluorescence ◽  
Near Infrared Fluorescence Imaging

One small molecule as a theranostic agent: naphthalimide dye for subcellular fluorescence localization and photodynamic therapy in vivo

MedChemComm ◽  
2016 ◽  
Vol 7 (6) ◽  
pp. 1171-1175 ◽  
Author(s):  
Lei Zhang ◽  
Kecheng Lei ◽  
Jingwen Zhang ◽  
Wenlin Song ◽  
Yuanhong Zheng ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Small Molecule ◽  
Single Molecule ◽  
Therapeutic Treatment ◽  
Agent Based ◽  
Theranostic Agent ◽  
Bright Fluorescence ◽  
Naphthalimide Dye

A small single-molecule theranostic agent based on naphthalimide was developed, which possessed both bright fluorescence imaging and effective photodynamic therapeutic treatment.

scholarly journals Protein enhanced NIR-IIb emission of indocyanine green for functional bioimaging

2020 ◽  
Author(s):  
Mubin He ◽  
Di Wu ◽  
Yuhuang Zhang ◽  
Xiaoxiao Fan ◽  
Hui Lin ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Fluorescence Imaging ◽  
Clinical Application ◽  
Spatial Resolution ◽  
Near Infrared ◽  
Protein Solutions ◽  
Lymph System ◽  
Fetal Bovine ◽  
Auto Fluorescence

AbstractFluorescence imaging performed in the 1500-1700 nm spectral range (labeled as near-infrared IIb, NIR-IIb) promises high imaging contrast and spatial resolution for its little photon scattering effect and minimum auto-fluorescence. Though inorganic and organic probes have been developed for NIR-IIb bioimaging, most are in preclinical stage, hampering further clinical application. Herein, we showed that indocyanine green (ICG), an US Food and Drug Administration (FDA)-approved agent, exhibited remarkable amount of NIR-IIb emission when dissolved into different protein solutions, including human serum albumin, rat bile, and fetal bovine serum. We performed fluorescence imaging in NIR-IIb window to visualize structures of lymph system, extrahepatic biliary tract and cerebrovascular. Results demonstrated that proteins promoted NIR-IIb emission of ICG in vivo and that NIR-IIb imaging with ICG preserved higher signal-to-background ratio (SBR) and spatial resolution compared with the conventional near-infrared II (NIR-II) fluorescence imaging. Our findings confirm that NIR-IIb fluorescence imaging can be successfully performed using the clinically approved agent ICG. Further clinical application in NIR-IIb region would hopefully be carried out with appropriate ICG-protein solutions.

scholarly journals Real-time navigation during hepatectomy using fusion indocyanine green-fluorescence imaging: protocol for a prospective cohort study

BMJ Open ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. e030233 ◽  
Author(s):  
Hidetoshi Gon ◽  
Shohei Komatsu ◽  
Sae Murakami ◽  
Masahiro Kido ◽  
Motofumi Tanaka ◽  
...  
Keyword(s):  
Body Weight ◽  
Indocyanine Green ◽  
Fluorescence Imaging ◽  
Imaging System ◽  
Imaging Techniques ◽  
Liver Tumours ◽  
Imaging Protocol ◽  
Indocyanine Green Fluorescence ◽  
Fluorescence Imaging System

IntroductionIn-vivo fluorescence imaging techniques using indocyanine green (ICG) to identify liver tumours and hepatic segment boundaries have been recently developed. The purpose of this study is to evaluate the efficacy of fusion ICG-fluorescence imaging for navigation during hepatectomy.Methods and analysisThis will be an exploratory single-arm clinical trial; patients with liver tumours will undergo hepatectomy using the ICG-fluorescence imaging system. In total, 110 patients with liver tumours scheduled for elective hepatectomy will be included in this study. Preoperatively, ICG will be intravenously injected at a dose of 0.5 mg/kg body weight within 2 days. To detect liver tumours intraoperatively, the hepatic surface will be initially observed using the ICG-fluorescence imaging system. After identifying and clamping the portal pedicle corresponding to the hepatic segments, including the liver tumours to be resected, additional ICG will be injected intravenously at a dose of 0.5 mg/kg body weight to identify the boundaries of the hepatic segments. The primary outcome measure will be the success or failure of the ICG-fluorescence imaging system in identifying hepatic segments. The secondary outcomes will be the success or failure in identifying liver tumours, liver function indicators, operative time, blood loss, rate of postoperative complications and recurrence-free survival. The findings obtained through this study are expected to help to establish the utility of ICG-fluorescence imaging systems, and therefore contribute to prognostic outcome improvements in patients undergoing hepatectomy for various causes.Ethics and disseminationThe protocol has been approved by the Kobe University Clinical Research Ethical Committee. The findings of this study will be disseminated widely through peer-reviewed publications and conference presentations.Trial registration numberUMIN000031054 and jRCT1051180070

pH-sensitive loaded retinal/indocyanine green micelles as an “all-in-one” theranostic agent for multi-modal imaging in vivo guided cellular senescence-photothermal synergistic therapy

2019 ◽  
Vol 55 (44) ◽  
pp. 6209-6212 ◽  
Author(s):  
Lipeng Zhu ◽  
Ping Li ◽  
Duyang Gao ◽  
Jie Liu ◽  
Yubin Liu ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Cellular Senescence ◽  
Ph Sensitive ◽  
Theranostic Agent

pH-sensitive loaded retinal/indocyanine green (ICG) micelles were developed for cellular senescence-photothermal synergistic therapy.

Liquid Exfoliation of Colloidal Rhenium Disulfide Nanosheets as a Multifunctional Theranostic Agent for In Vivo Photoacoustic/CT Imaging and Photothermal Therapy

Small ◽  
2018 ◽  
Vol 14 (14) ◽  
pp. 1703789 ◽  
Author(s):  
Zhao-Hua Miao ◽  
Lan-Xiang Lv ◽  
Kai Li ◽  
Pei-Ying Liu ◽  
Zhenglin Li ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Ct Imaging ◽  
Liquid Exfoliation ◽  
Theranostic Agent

scholarly journals Real-Time Fluorescence Imaging Using Indocyanine Green to Assess Therapeutic Effects of Near-Infrared Photoimmunotherapy in Tumor Model Mice

2020 ◽  
Vol 19 ◽  
pp. 153601212093496
Author(s):  
Adrian Rosenberg ◽  
Daiki Fujimura ◽  
Ryuhei Okada ◽  
Aki Furusawa ◽  
Fuyuki Inagaki ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Real Time ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Imaging System ◽  
Tumor Model ◽  
Therapeutic Effects ◽  
Tumor Perfusion ◽  
Background Ratio

Background: Near-infrared photoimmunotherapy (NIR-PIT) is a cancer therapy that causes an increase in tumor perfusion, a phenomenon termed the super-enhanced permeability and retention effect. Currently, in vivo treatment efficacy of NIR-PIT is observable days after treatment, but monitoring would be improved by more acute detection of intratumor change. Fluorescence imaging may detect increased tumor perfusion immediately after treatment. Methods: In the first experiment, athymic nude mouse models bearing unilateral subcutaneous flank tumors were treated with either NIR-PIT or laser therapy only. In the second experiment, mice bearing bilateral flank tumors were treated with NIR-PIT only on the left-sided tumor. In both groups, immediately after treatment, indocyanine green was injected at different doses intravenously, and mice were monitored with the Shimadzu LIGHTVISION fluorescence imaging system for 1 hour. Results: Tumor-to-background ratio of fluorescence intensity increased over the 60 minutes of monitoring in treated mice but did not vary significantly in control mice. Tumor-to-background ratio was highest in the 1 mg kg−1 and 0.3 mg kg−1 doses. In mice with bilateral tumors, tumor-to-untreated tumor ratio increased similarly. Conclusions: Acute changes in tumor perfusion after NIR-PIT can be detected by real-time fluorescence imaging.

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