scholarly journals Synthesis of mesoporous silica nanoparticles and drug loading of poorly water soluble drug cyclosporin A

2012 ◽  
Vol 4 (5) ◽  
pp. 92 ◽  
Author(s):  
A Lodha ◽  
M Lodha ◽  
A Patel ◽  
J Chaudhuri ◽  
J Dalal ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Cyclosporin A ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading ◽  
Water Soluble ◽  
Water Soluble Drug ◽  
Poorly Water Soluble ◽  
Poorly Water Soluble Drug

scholarly journals Enlarged Pore Size Chiral Mesoporous Silica Nanoparticles Loaded Poorly Water-Soluble Drug Perform Superior Delivery Effect

Molecules ◽  
2019 ◽  
Vol 24 (19) ◽  
pp. 3552 ◽  
Author(s):  
Yingyu Guo ◽  
Kaijun Gou ◽  
Baixue Yang ◽  
Yumei Wang ◽  
Xueyu Pu ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Delivery System ◽  
Mesoporous Silica Nanoparticles ◽  
Water Soluble ◽  
Synthesis Process ◽  
Water Soluble Drug ◽  
Poorly Water Soluble ◽  
Anti Inflammatory ◽  
Poorly Water Soluble Drug

Large mesopores of chiral silica nanoparticles applied as drug carrier are worth studying. In this study, chiral mesoporous silica nanoparticles (CMSN) and enlarged chiral mesoporous silica nanoparticles (E-CMSN) with a particle size from 200 to 300 nm were synthesized. Fourier transform infrared spectrometer (FTIR), circular dichroism spectrum, scanning electron microscopy (SEM), transmission electron microscope (TEM), and nitrogen adsorption/desorption measurement were adopted to explore their characteristics. The results showed that the surface area, pore volume, and pore diameter of E-CMSN were higher than those of CMSN due to enlarged mesopores. Poorly water-soluble drug nimesulide (NMS) was taken as the model drug and loaded into carriers using adsorption method. After NMS was loaded into CMSN and E-CMSN, most crystalline NMS converted to amorphous phase and E-CMSN was superior. The anti-inflammatory pharmacodynamics and in vivo pharmacokinetics results were consistent with the wetting property and in vitro drug dissolution results, verifying that NMS/E-CMSN exhibited superior NMS delivery system based on its higher oral relative bioavailability and anti-inflammatory effect because its enlarge mesopores contributed to load and release more amorphous NMS. The minor variations in the synthesis process contributed to optimize the chiral nano-silica drug delivery system.

scholarly journals Improving dissolution profile of poorly water-soluble drug using non-ordered mesoporous silica

2018 ◽  
Vol 22 (2) ◽  
pp. 249-258 ◽  
Author(s):  
Jyotsana R. Madan ◽  
Shronavi Patil ◽  
Dyandevi Mathure ◽  
Santosh P. Bahirat ◽  
Rajendra Awasthi
Keyword(s):  
Mesoporous Silica ◽  
Water Soluble ◽  
Dissolution Profile ◽  
Ordered Mesoporous Silica ◽  
Water Soluble Drug ◽  
Ordered Mesoporous ◽  
Poorly Water Soluble ◽  
Poorly Water Soluble Drug

scholarly journals Novel application of mixed solvency concept in the development of oral liquisolid system of a poorly soluble drug, cefixime and its evaluation

2018 ◽  
Vol 8 (6-s) ◽  
pp. 5-8 ◽  
Author(s):  
Rinshi Agrawal ◽  
RK Maheshwari
Keyword(s):  
Drug Loading ◽  
Research Work ◽  
Water Soluble ◽  
Dsc Studies ◽  
Water Soluble Drug ◽  
Poorly Soluble ◽  
Poorly Water Soluble ◽  
Poorly Soluble Drug ◽  
Model Drug ◽  
Poorly Water Soluble Drug

Application of mixed solvency has been employed in the present research work to develop a liquisolid system (Powder formulation) of poorly water soluble drug, cefixime (as model drug). Material and Methods: For poorly water soluble drug cefixime, combination of solubilizers such as sodium acetate, sodium caprylate and propylene glycol as mixed solvent systems were used to decrease the overall concentration of solubilizers required to produce substantial increase in solubility and thereby resulting in enhanced drug loading capacity of cefixime. The procured sample of cefixime was characterized by melting point, IR, UV and DSC studies. Stability studies of liquisolid system of cefixime were performed for two months at room temperature, 30˚C and 40˚C. All the formulations were physically, chemically, and microbiologically stable. Conclusion: Mixed solvency concept has been successfully employed for enhancing the drug loading of poorly water soluble drug, cefixime. Keywords: Solubility, cefixime, liquisolid system, mixed solvency concept.

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