Nanocomposite sponges of sodium alginate/graphene oxide/polyvinyl alcohol as potential wound dressing: In vitro and in vivo evaluation

The present research aimed to examine the biological properties of chitosan (CS)–polyvinyl alcohol (PVA) scaffolds reinforced with graphene oxide (GO) nanosheets, as wound dressings. The scaffolds were characterized by various techniques. The scanning electron microscopy (SEM) and thermogravimetry analyses (TGAs) were used to investigate distribution of the GO within the polymer. The viscoelastic properties were evaluated by dynamic mechanical thermal analysis (DMTA) to examine the quality of a wound dressing. In vitro and in vivo studies were conducted to assess the biocompatibility of the scaffolds as wound dressing. The cell viability and proliferation results indicated that mouse fibroblast cells (L929) could adhere on the 50CS–50PVA/3 wt% GO scaffold. Herewith, the fabricated CS–PVA–GO nanocomposite scaffolds are suggested as promising biomaterials for skin tissue engineering and wound dressing.

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In vitro and in vivo study of carboxymethyl chitosan/polyvinyl alcohol for wound dressing application

Journal of Applied Polymer Science ◽

10.1002/app.51764 ◽

2021 ◽

pp. 51764

Author(s):

Alireza Akbari ◽

Shahram Rabbani ◽

Shiva Irani ◽

Mojgan Zandi ◽

Fereshteh Sharifi ◽

...

Keyword(s):

Polyvinyl Alcohol ◽

Wound Dressing ◽

Carboxymethyl Chitosan ◽

In Vivo Study

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Curcumin-incorporated crosslinked sodium alginate-g-poly (N-isopropyl acrylamide) thermo-responsive hydrogel as an in-situ forming injectable dressing for wound healing: in vitro characterization and in vivo evaluation

Carbohydrate Polymers ◽

10.1016/j.carbpol.2021.118434 ◽

2021 ◽

pp. 118434

Author(s):

Mohammad Zakerikhoob ◽

Sahar Abbasi ◽

Gholamhossein Yousefi ◽

Maral Mokhtari ◽

Mohammad Sadegh Noorbakhsh

Keyword(s):

Wound Healing ◽

Sodium Alginate ◽

In Vivo Evaluation ◽

In Situ Forming ◽

In Vitro Characterization ◽

Isopropyl Acrylamide

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Novel scaffold based graphene oxide doped electrospun iota carrageenan/polyvinyl alcohol for wound healing and pathogen reduction: in-vitro and in-vivo study

Scientific Reports ◽

10.1038/s41598-021-00069-0 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Marwa H. Gouda ◽

Safaa M. Ali ◽

Sarah Samir Othman ◽

Samia A. Abd Al-Aziz ◽

Marwa M. Abu-Serie ◽

...

Keyword(s):

Wound Healing ◽

Graphene Oxide ◽

Polyvinyl Alcohol ◽

Hematological Parameters ◽

Nutritional Supplement ◽

Hair Follicles ◽

Nanofiber Scaffold ◽

Novel Scaffold

AbstractWound healing is a complicated multicellular process that involves several kinds of cells including macrophages, fibroblasts, endothelial cells, keratinocytes and platelets that are leading to their differentiation towards an anti-inflammatory response for producing several chemokines, cytokine and growth factors. In this study, electrospun nanofiber scaffold named (MNS) is composed of polyvinyl alcohol (PVA)/iota carrageenan (IC) and doped with partially reduced graphene oxide (prGO) that is successfully synthesized for wound healing and skin repair. The fabricated MNS was tested in case of infection and un-infection with E. coli and Staphylococcus and in both of the presence and in the absence of yeast as a natural nutritional supplement. Numerous biochemical parameters including total protein, albumin, urea and LDH, and hematological parameters were evaluated. Results revealed that the MNS was proved to be effective on most of the measured parameters and had exhibited efficient antibacterial inhibition activity. Whereas it can be used as an effective antimicrobial agent in wound healing, however, histopathological findings confirmed that the MNS caused re-epithelialization and the presence of yeast induced hair follicles growth and subsequently it may be used to hide formed head wound scar.

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