Class Regular–Increased– and Class Iso–Toxicity, the two clearly defined and recognisable forms of the phenomenon. A developed Köln–Model (Hydractinia echinata Test–System. V.) study

2019 ◽  
Vol 10 ◽  
pp. 17-25
Author(s):  
Sergiu Adrian Chicu
Keyword(s):  
Test System ◽  
Hydractinia Echinata

scholarly journals The Hydractinia echinata Test-System. III: Structure-Toxicity Relationship Study of Some Azo-, Azo-Anilide, and Diazonium Salt Derivatives

Molecules ◽  
2014 ◽  
Vol 19 (7) ◽  
pp. 9798-9817 ◽  
Author(s):  
Sergiu Chicu ◽  
Melania Munteanu ◽  
Ioana Cîtu ◽  
Codruta Şoica ◽  
Cristina Dehelean ◽  
...  
Keyword(s):  
Diazonium Salt ◽  
Test System ◽  
Hydractinia Echinata ◽  
Relationship Study ◽  
Structure Toxicity Relationship ◽  
Toxicity Relationship

SAR for Amine Salts of Carboxylic Acids to Hydractinia echinata

2008 ◽  
Vol 59 (5) ◽  
Author(s):  
Sergiu Adrian Chicu ◽  
Mata Grozav ◽  
Ludovic Kurunczi ◽  
Manuela Crisan
Keyword(s):  
Carboxylic Acids ◽  
Marine Organism ◽  
Marine Invertebrate ◽  
Toxicity Testing ◽  
Test System ◽  
Transformation Process ◽  
Neutral Species ◽  
Sessile Polyp ◽  
Hydractinia Echinata ◽  
Amine Salts

The relationship between the structure and biological activity (toxicity) SAR of the stoichiometric mixtures between anion and cation (or neutral species) proceeded at pH 8.2 from the different amine salts of benzoic, acetic, oxalic, naphthalene carboxylic acids was determined. Their toxicity was determined by using the metamorphosis (transformation) process of the marine invertebrate Hydractinia echinata (Hydrozoa, Cnidaria) from the freely swimming larva to a sessile polyp as a biological test system. The two components of the stoichiometric mixture, the anion and the cation or neutral species react independently, but in a parallel way, the effectiveness of the cation/neutral species being superior. The studied compounds were grouped by their cationic/neutral structure and measured toxicity. All of these series were also characterized by a calculated mean value of the toxicity. The marine organism, Hydractinia echinata was a good and advantageous alternative for the toxicity testing systems with vertebrate.

Hydractinia echinata test system. II. SAR toxicity study of some anilide derivatives of Naphthol-AS type

Chemosphere ◽  
2011 ◽  
Vol 82 (11) ◽  
pp. 1578-1582 ◽  
Author(s):  
Sergiu Adrian Chicu ◽  
Simona Funar-Timofei ◽  
Georgeta-Maria Simu
Keyword(s):  
Test System ◽  
Toxicity Study ◽  
Hydractinia Echinata ◽  
Derivatives Of

Hydractinia echinata test-system. IV. Toxic synergism of human pharmaceuticals in mixtures with iodoform

2016 ◽  
Vol 134 ◽  
pp. 80-85 ◽  
Author(s):  
Sergiu A. Chicu ◽  
Ladislaus Schannen ◽  
Mihai V. Putz ◽  
Georgeta-M. Simu
Keyword(s):  
Test System ◽  
Hydractinia Echinata

Immunogold labeling of CMP-KDO synthetase produced by recombinant E. Coli cells

1987 ◽  
Vol 45 ◽  
pp. 924-925
Author(s):  
F. A. Durum ◽  
R. G. Goldman ◽  
T. J. Bolling ◽  
M. F. Miller
Keyword(s):  
Inclusion Bodies ◽  
Large Scale ◽  
Recombinant Dna ◽  
Test System ◽  
Cell Protein ◽  
Gram Negative Bacteria ◽  
Cytoplasmic Inclusions ◽  
Isolation And Purification ◽  
E Coli ◽  
Low Concentrations

CMP-KDO synthetase (CKS) is an enzyme which plays a key role in the synthesis of LPS, an outer membrane component unique to gram negative bacteria. CKS activates KDO to CMP-KDO for incorporation into LPS. The enzyme is normally present in low concentrations (0.02% of total cell protein) which makes it difficult to perform large scale isolation and purification. Recently, the gene for CKS from E. coli was cloned and various recombinant DNA constructs overproducing CKS several thousandfold (unpublished data) were derived. Interestingly, no cytoplasmic inclusions of overproduced CKS were observed by EM (Fig. 1) which is in contrast to other reports of large proteinaceous inclusion bodies in various overproducing recombinant strains. The present immunocytochemical study was undertaken to localize CKS in these cells.Immune labeling conditions were first optimized using a previously described cell-free test system. Briefly, this involves soaking small blocks of polymerized bovine serum albumin in purified CKS antigen and subjecting them to various fixation, embedding and immunochemical conditions.

Real Ear Sound Pressure Levels Developed by Three Portable Stereo System Earphones

1992 ◽  
Vol 1 (4) ◽  
pp. 52-55 ◽  
Author(s):  
Gail L. MacLean ◽  
Andrew Stuart ◽  
Robert Stenstrom
Keyword(s):  
High Frequency ◽  
Sound Pressure ◽  
Low Frequency ◽  
Test System ◽  
Output Frequency ◽  
Frequency Effects ◽  
Adult Men ◽  
Frequency Responses ◽  
Significant Difference ◽  
Sound Pressure Levels

Differences in real ear sound pressure levels (SPLs) with three portable stereo system (PSS) earphones (supraaural [Sony Model MDR-44], semiaural [Sony Model MDR-A15L], and insert [Sony Model MDR-E225]) were investigated. Twelve adult men served as subjects. Frequency response, high frequency average (HFA) output, peak output, peak output frequency, and overall RMS output for each PSS earphone were obtained with a probe tube microphone system (Fonix 6500 Hearing Aid Test System). Results indicated a significant difference in mean RMS outputs with nonsignificant differences in mean HFA outputs, peak outputs, and peak output frequencies among PSS earphones. Differences in mean overall RMS outputs were attributed to differences in low-frequency effects that were observed among the frequency responses of the three PSS earphones. It is suggested that one cannot assume equivalent real ear SPLs, with equivalent inputs, among different styles of PSS earphones.

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