The current study investigated the construct validity of a popular measure of trait self-control, the Self-Control Scale (SCS; Tangney, Baumeister, & Boone (2004)), by examining its relationship with social desirability in three complementary ways. First, a meta-analysis (k = 55, N = 14,836) demonstrated a substantial correlation between the SCS and social desirability (r = .41, 95% Confidence Interval = [.38, .45]). Second, among the meta-analyzed studies, social desirability scales were predominantly used as a measure of response bias. Finally, simulations demonstrated that the overlap between the SCS and social desirability presents major methodological and interpretation challenges under some circumstances. These results call for further investigations into the nature of the overlapping variance between the SCS and social desirability.