scholarly journals Single and repeated dose (28 days) intravenous toxicity assessment of bartogenic acid (an active pentacyclic triterpenoid) isolated from Barringtonia racemosa (L.) fruits in mice

2021 ◽  
Author(s):  
Vishal Kumar Dubey ◽  
Swati Madan ◽  
Satyendra K. Rajput ◽  
Anu T Singh ◽  
Manu Jaggi
Keyword(s):  
Toxicity Assessment ◽  
Repeated Dose ◽  
Pentacyclic Triterpenoid

Toxicity assessment of the aqueous root extract of Sanseviera Liberica (Agavaceae)

Planta Medica ◽  
2006 ◽  
Vol 72 (11) ◽  
Author(s):  
OO Adeyemi ◽  
MB Amida ◽  
OK Yemitan
Keyword(s):  
Toxicity Assessment ◽  
Root Extract ◽  
Aqueous Root Extract

Effect of carbofuran on quantitative and qualitative alterations in haemolymph of larva of Oryctes rhinoceros L. (Coleoptera: Scarabaeidae)

ENTOMON ◽  
2020 ◽  
Vol 44 (4) ◽  
pp. 293-300
Author(s):  
V.S. Salini
Keyword(s):  
Oral Route ◽  
Toxicity Assessment ◽  
Haematological Parameters ◽  
Oryctes Rhinoceros ◽  
Total Haemocyte Count ◽  
Differential Haemocyte Count ◽  
Third Instar Larvae

Investigation to evaluate the toxicity of carbofuran pesticides on haematological parameters of third instar larvae of Oryctes rhinoceros L. Indicated alterations in total haemocyte count and differential haemocyte count for toxicity assessment. Various doses of carbofuran (0.05g, 0.010g and 0.015 g) applied on insect through oral route and its impact after 24 hours of its application revealed that various doses of carbofuran exert specific alterations in both total and differential haemocytes of insect haemolymph.

Oral Repeated-dose Toxicity Studies Especially in the Liver and Kidney of Rats Administered with Organic Germanium-fortified Yeasts

2006 ◽  
Vol 11 (2) ◽  
pp. 115-119 ◽  
Author(s):  
Sung-Hee Lee ◽  
Kyeong-Nam Oh ◽  
Sook-Nyung Rho ◽  
Bok-Hee Lee ◽  
Hyun-Joo Lee
Keyword(s):  
Repeated Dose ◽  
Toxicity Studies ◽  
Repeated Dose Toxicity ◽  
Liver And Kidney

Decolorization, Degradation and Subsequent Toxicity Assessment of Reactive Red 35 by Enterococcus gallinarum

2016 ◽  
Vol 5 (4) ◽  
pp. 325-336 ◽  
Author(s):  
Rakesh Soni ◽  
N.S. Bhatt ◽  
H.A. Modi ◽  
P.B. Acharya
Keyword(s):  
Toxicity Assessment ◽  
Enterococcus Gallinarum

Acute and Sub-acute Oral Toxicity Assessment of a Standardized Polyherbal Preparation POL-6 in Rats

2019 ◽  
Vol 9 (3) ◽  
pp. 207-216
Author(s):  
Lalit Sharma ◽  
Aditi Sharma ◽  
Girdhari L. Gupta ◽  
Gopal Singh Bisht
Keyword(s):  
Histopathological Examination ◽  
Safety Evaluation ◽  
Centella Asiatica ◽  
Toxicity Assessment ◽  
Ocimum Sanctum ◽  
Oral Toxicity ◽  
Significant Treatment ◽  
Body Weights ◽  
Total Body ◽  
Hematobiochemical Parameters

Background: A standardized polyherbal preparation (POL-6) containing six plant extracts Hypericum perforatum, Bacopa monnieri, Centella asiatica, Withania somnifera, Ocimum sanctum and Camellia sinesis have good antioxidant, anti-inflammatory, and immunomodulatory activities. The present study was carried out to evaluate the safety profile of POL-6 through acute and subacute oral toxicity models in Wistar rats. Methods: In acute safety evaluation, a single dose of 2000mg/kg of POL-6 was given orally to five rats and was observed for 14 days. In subacute safety evaluation POL-6 at the doses of 250, 500 and 1000 mg/kg was given orally to the rats once a day for 28 days. The animals were observed for the signs of toxicity and mortality during the study period. Results: In acute toxicity evaluation, POL-6 treatment did not show any toxic signs and mortality in animals during the observation period. In subacute toxicity studies, no changes were seen in any of the dose levels of POL-6 treatment during the total body weights, organ weights and hematobiochemical parameters examination of the rats. No lesions were seen during the gross/histopathological examination. Conclusion: The study revealed that administration of POL-6 for 28 days showed no significant treatment generated toxic effects in the animals, hence it can be considered as non-toxic if it is ingested in a time not greater than a month.

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