scholarly journals Intracellular interleukin-1 receptor antagonist type 1 antagonizes the stimulatory effect of interleukin-1α precursor on cell motility

Cytokine ◽  
2005 ◽  
Vol 32 (3-4) ◽  
pp. 163-170 ◽  
Author(s):  
Faten Merhi-Soussi ◽  
Marina Berti ◽  
Bernhard Wehrle-Haller ◽  
Cem Gabay
2001 ◽  
Vol 75 (13) ◽  
pp. 6242-6244 ◽  
Author(s):  
Steven S. Witkin ◽  
Iara M. Linhares ◽  
Stefan Gerber ◽  
Marie E. Caetano ◽  
Alusio C. Segurado

ABSTRACT Interleukin-1 receptor antagonist (IL-1ra) gene polymorphisms in 83 human immunodeficiency virus (HIV)-seropositive women were evaluated. Fourteen of the subjects (16.9%) were homozygous for IL-1ra allele 2 (IL-1RN*2). These women had a lower median level of HIV RNA than did women homozygous for allele 1 (IL-1RN*1) (P = 0.01) or heterozygous for both alleles (P = 0.04). Among 46 subjects not receiving antiretroviral treatment, HIV levels were also reduced in IL-1RN*2 homozygous individuals (P< 0.05). There was no relation between IL-1ra alleles and CD4 levels.


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