scholarly journals Daam2 Is Required for Dorsal Patterning via Modulation of Canonical Wnt Signaling in the Developing Spinal Cord

2012 ◽  
Vol 22 (1) ◽  
pp. 183-196 ◽  
Author(s):  
Hyun Kyoung Lee ◽  
Benjamin Deneen
Keyword(s):  
Spinal Cord ◽  
Wnt Signaling ◽  
Canonical Wnt Signaling ◽  
Canonical Wnt ◽  
Developing Spinal Cord

scholarly journals Proliferation and patterning are mediated independently in the dorsal spinal cord downstream of canonical Wnt signaling

2008 ◽  
Vol 313 (1) ◽  
pp. 398-407 ◽  
Author(s):  
Jennifer Bonner ◽  
Suzanna L. Gribble ◽  
Eric S. Veien ◽  
O. Brant Nikolaus ◽  
Gilbert Weidinger ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Wnt Signaling ◽  
Canonical Wnt Signaling ◽  
Dorsal Spinal Cord ◽  
Canonical Wnt ◽  
Dorsal Spinal

scholarly journals Therapeutic Potential of Wnt-3a in Neurological Recovery after Spinal Cord Injury

2019 ◽  
Vol 81 (3-4) ◽  
pp. 197-204 ◽  
Author(s):  
Kai Gao ◽  
Tao Zhang ◽  
Fang Wang ◽  
Chaoliang Lv
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Wnt Signaling ◽  
Signaling Pathway ◽  
Molecular Mechanism ◽  
Therapeutic Potential ◽  
Wnt Signaling Pathway ◽  
Canonical Wnt Signaling ◽  
Cord Injury ◽  
Canonical Wnt

Background: Spinal cord injury (SCI) is a constant challenge in medical research and a global therapeutic problem. Treatment of this condition remains difficult in clinical practice. Hence, prevention, treatment, and rehabilitation of SCI have become imminent tasks in the medical field. Summary: Recent evidence suggest the important role of Wnt/β-catenin signaling pathway, a canonical Wnt signaling pathway, in neural development, axon guidance, neuropathic pain relief, and neuronal survival. Wnt-3a is regarded as an activator of the canonical Wnt signaling pathway. This activator is expressed in the dorsal midline region and is responsible for spinal cord development. In addition, Wnt-3a plays a regulatory role in autophagy, apoptosis, and regeneration of neurons; neurogenic inflammation; and axon regeneration. Herein, we demonstrated that neuronal autophagy was regulated by Wnt-3a via β-catenin and mammalian target of rapamycin signaling pathways after SCI. Our study also discovered that the Wnt-3a provided a favorable microenvironment for the recovery of nerve function after SCI. Key Messages: This study systematically elaborates the neuroprotective effect of Wnt-3a and its neuroprotection molecular mechanism after SCI. This study provides a new molecular mechanism and research basis for clinical treatment of SCI.

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