Canonical Wnt signaling in bone health and disease

2017 ◽  
Author(s):  
Hul Wim Van
Keyword(s):  
Wnt Signaling ◽  
Bone Health ◽  
Canonical Wnt Signaling ◽  
Health And Disease ◽  
Canonical Wnt

scholarly journals Pathophysiological aspects of Wnt-signaling in endocrine disease

2009 ◽  
Vol 160 (5) ◽  
pp. 731-737 ◽  
Author(s):  
Sven Schinner ◽  
Holger S Willenberg ◽  
Matthias Schott ◽  
Werner A Scherbaum
Keyword(s):  
Wnt Signaling ◽  
Intracellular Signaling ◽  
Cell Function ◽  
Endocrine Disorders ◽  
Canonical Wnt Signaling ◽  
Endocrine Organs ◽  
Β Cell Function ◽  
Frizzled Receptors ◽  
Health And Disease ◽  
Canonical Wnt

Wnt-signaling has recently been identified as a regulator of a number of endocrine functions in health and disease in addition to its original attribution to developmental biology. Wnts are extracellular ligands on frizzled receptors and on lipoprotein receptor-related protein co-receptors. Ligand binding leads eventually to the activation of intracellular signaling cascades; based on the involvement of the transcriptional co-activator β-catenin it can be distinguished between canonical (i.e. β-catenin) and non-canonical Wnt-signaling. Recent studies revealed that canonical Wnt-signaling regulates the function of endocrine organs and contributes to a number of endocrine disorders. In this review, we would like to focus on a) recent mechanistic data on Wnts in pancreatic β-cell function; b) human genetic studies on Wnt signaling in type 2 diabetes mellitus; c) crosstalk between adipocytes and endocrine cells through Wnt-signaling molecules (with a focus on the role of Wnt-signaling in adrenocortical cells).

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