TREX1-dependent DNA damage links nuclear rupture to tumor cell invasion

2021 ◽  
Vol 56 (22) ◽  
pp. 3040-3041
Author(s):  
Edgar R. Gomes ◽  
Sérgio F. de Almeida
Keyword(s):  
Dna Damage ◽  
Tumor Cell ◽  
Cell Invasion ◽  
Tumor Cell Invasion ◽  
Nuclear Rupture

Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion

Cell ◽  
2021 ◽  
Author(s):  
Guilherme Pedreira de Freitas Nader ◽  
Sonia Agüera-Gonzalez ◽  
Fiona Routet ◽  
Matthieu Gratia ◽  
Mathieu Maurin ◽  
...  
Keyword(s):  
Dna Damage ◽  
Tumor Cell ◽  
Nuclear Envelope ◽  
Cell Invasion ◽  
Tumor Cell Invasion

CUTL1–a modulator of tumor cell invasion and target of TGF-beta which is highly expressed in colon cancer

2004 ◽  
Vol 42 (08) ◽  
Author(s):  
P Michl ◽  
M Ei'Bahrawy ◽  
R Poulsom ◽  
A Ramjaun ◽  
J Downward
Keyword(s):  
Colon Cancer ◽  
Tumor Cell ◽  
Cell Invasion ◽  
Tumor Cell Invasion ◽  
Tgf Beta

Tumor Cell Invasion Assay

BIO-PROTOCOL ◽  
2012 ◽  
Vol 2 (3) ◽  
Author(s):  
Yanling Chen
Keyword(s):  
Tumor Cell ◽  
Cell Invasion ◽  
Tumor Cell Invasion ◽  
Invasion Assay

scholarly journals Regulation of CD44 Alternative Splicing by SRm160 and Its Potential Role in Tumor Cell Invasion

2006 ◽  
Vol 26 (1) ◽  
pp. 362-370 ◽  
Author(s):  
Chonghui Cheng ◽  
Phillip A. Sharp
Keyword(s):  
Alternative Splicing ◽  
Tumor Cell ◽  
Cell Invasion ◽  
Rna Splicing ◽  
Tumor Cell Invasion ◽  
Dependent Manner ◽  
Cd44 Isoforms ◽  
Transmembrane Glycoprotein ◽  
Cell Invasiveness ◽  
Interfering Rna

ABSTRACT The multiple isoforms of the transmembrane glycoprotein CD44 are produced by alternative RNA splicing. Expression of CD44 isoforms containing variable 5 exon (v5) correlates with enhanced malignancy and invasiveness of some tumors. Here we demonstrate that SRm160, a splicing coactivator, regulates CD44 alternative splicing in a Ras-dependent manner. Overexpression of SRm160 stimulates inclusion of CD44 v5 when Ras is activated. Conversely, small interfering RNA (siRNA)-mediated silencing of SRm160 significantly reduces v5 inclusion. Immunoprecipitation shows association of SRm160 with Sam68, a protein that also stimulates v5 inclusion in a Ras-dependent manner, suggesting that these two proteins interact to regulate CD44 splicing. Importantly, siRNA-mediated depletion of CD44 v5 decreases tumor cell invasion. Reduction of SRm160 by siRNA transfection downregulates the endogenous levels of CD44 isoforms, including v5, and correlates with a decrease in tumor cell invasiveness.

scholarly journals Rakicidin D, an inhibitor of tumor cell invasion from marine-derived Streptomyces sp.

2010 ◽  
Vol 63 (9) ◽  
pp. 563-565 ◽  
Author(s):  
Yasuhiro Igarashi ◽  
Ryoko Shimasaki ◽  
Satoshi Miyanaga ◽  
Naoya Oku ◽  
Hiroyasu Onaka ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Invasion ◽  
Tumor Cell Invasion ◽  
Streptomyces Sp

scholarly journals An Immortalization-Dependent Switch in Integrin Function Up-regulates MMP-9 to Enhance Tumor Cell Invasion

2008 ◽  
Vol 68 (18) ◽  
pp. 7371-7379 ◽  
Author(s):  
John M. Lamar ◽  
Kevin M. Pumiglia ◽  
C. Michael DiPersio
Keyword(s):  
Tumor Cell ◽  
Cell Invasion ◽  
Tumor Cell Invasion ◽  
Enhance Tumor Cell
Sign in / Sign up

Export Citation Format

Share Document