Current type 2 diabetes, rather than previous gestational diabetes, is associated with liver disease in U.S. women

2021 ◽  
pp. 108879
Author(s):  
Stefano Ciardullo ◽  
Eleonora Bianconi ◽  
Francesca Zerbini ◽  
Gianluca Perseghin
Keyword(s):  
Type 2 Diabetes ◽  
Liver Disease ◽  
Gestational Diabetes ◽  
Previous Gestational Diabetes

Do Postpartum Levels of Apolipoproteins Prospectively Predict the Development of Type 2 Diabetes in Women with Previous Gestational Diabetes Mellitus?

2018 ◽  
Vol 127 (06) ◽  
pp. 353-358
Author(s):  
Martha Lappas ◽  
Harry M Georgiou ◽  
Anida Velagic ◽  
Jane C Willcox ◽  
Michael Permezel ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Apo B ◽  
Apo E ◽  
Previous Gestational Diabetes Mellitus ◽  
Apo Ai ◽  
Previous Gestational Diabetes

Abstract Aims The risk of developing type 2 diabetes is greater in women with previous gestational diabetes mellitus (GDM). Apolipoprotein (Apo) species have been associated with the development of type 2 diabetes in the general population. The aim of this study was to determine if circulating levels of Apo species can predict development of type 2 diabetes in women with previous GDM. Methods Apo AI, Apo AII, Apo B, Apo CII, Apo CIII and Apo E levels were measured in 95 women with normal glucose tolerance, 12 weeks following an index GDM pregnancy. Women were assessed for up to 10 years for the development of type 2 diabetes. Results Postpartum Apo CIII levels, and Apo CIII/Apo AI, Apo CIII/Apo AII, Apo CIII/Apo CII, Apo CIII/Apo E and Apo E/Apo CIII ratios were significantly and positively associated with the development of type 2 diabetes. After controlling for age and BMI, these associations, except for the Apo E/Apo CIII ratio, remained significant. In a clinical model of prediction of type 2 diabetes that included age, BMI, and pregnancy and postnatal fasting glucose, the addition of Apo CIII levels, Apo CIII/Apo AI, Apo CIII/Apo AII, Apo CIII/Apo CII, and Apo CIII/Apo E resulted in a net reclassification improvement of 16.2%. Conclusions High Apo CIII levels and the Apo CIII/Apo AI, Apo CIII/Apo AII, Apo CIII/Apo CII, and Apo CIII/Apo E ratios are all significant risk factors for the development of type 2 diabetes in women with a previous GDM pregnancy.

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